Patents by Inventor Frederic Bassilana

Frederic Bassilana has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Organic compounds
    Patent number: 10203327
    Abstract: The present invention relates to modulators of the interaction between G-protein coupled receptor 15(GPR15) and c10orf99. The modulator may be a small chemical molecule, antibody or other therapeutic protein. Methods of medical treatment and methods of identifying modulators are also described.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: February 12, 2019
    Assignees: Novartis AG, Odega S.A.
    Inventors: Frederic Bassilana, Birgit Uta Baumgarten, Nathalie Marie-Therese Carte, Michel Detheux, Rocco Falchetto, Sebastien Hannedouche, Vincent Lannoy, Keith Mansfield, Klaus Peter Seuwen, Thomas Laurent Henri Suply
  • ORGANIC COMPOUNDS
    Publication number: 20160274110
    Abstract: The present invention relates to modulators of the interaction between G-protein coupled receptor 15(GPR15) and c10orf99. The modulator maybe a small chemical molecule, antibody or other therapeutic protein. Methods of medical treatment and methods of identifying modulators are also described.
    Type: Application
    Filed: October 23, 2014
    Publication date: September 22, 2016
    Applicants: NOVARTIS AG, EUROSCREEN S.A.
    Inventors: Frederic BASSILANA, Birgit Uta BAUMGARTEN, Nathalie Marie-Therese CARTE, Michel DETHEUX, Rocco FALCHETTO, Sebastien HANNEDOUCHE, Vincent LANNOY, Keith MANSFIELD, Klaus Peter SEUWEN, Thomas Laurent Henri Suply
  • Identification, functional expression and chromosal localization of a sustained human proton-gated cation channel
    Patent number: 6287859
    Abstract: Non inactivating or slowly inactivating proton-gated cation channels are thought to play an important role in the perception of pain that accompanies tissue acidosis. We have identified a novel human proton-gated cation channel subunit that has biphasic desensitisation kinetics with both a rapidly inactivating Na+-selective and a sustained component. The protein shares 84% sequence identity with the proton-gated cation channel rASIC3 (rDRASIC) from rat sensory neurones. The biphasic desensitisation kinetics and the sequence homology suggest that this novel clone (hASIC3) is the human orthologue of rASIC3 (rDRASIC). While rASIC3 (rDRASIC) requires very acidic pH (<pH 4.5) for activation of the sustained current, the non-inactivating hASIC3 current starts to be activated when the pH decreases to below pH 6. hASIC3 is ant acid sensor and might play an important role in the detection of lasting pH changes in human. We localized the hASIC3 gene to the human chromosome 7q35, 6.
    Type: Grant
    Filed: July 23, 1999
    Date of Patent: September 11, 2001
    Assignee: Centre National de la Recherche
    Inventors: Jan R. DeWeille, Frederic Bassilana, Michel Lazdunski, Waldmann Rainer