Abstract: The invention relates to means and methods for assessing clonal immunoglobulin (IG)/T cell receptor (TR) gene rearrangements in a clinical, diagnostic and/or research setting. Provided is a quality control composition comprising a mixture of genomic DNA isolated from a set of nine cultured cell lines, said set comprising the B cell lines ALL/MIK (ALL), Raji (Burkitt lymphoma), REH (B cell precursor ALL), TMM (CML-BC/EBV+B-LCL), TOM-1 (B cell precursor ALL), WSU-NHL (B cell lymphoma) and the T cell lines JB6 (ALCL), Karpas299 (ALCL) and MOLT-13 (ALL), or wherein one or more cell lines of said set is replaced with one or more other cell line(s) comprising the same IG/TR gene rearrangements. Also provided is a quality control composition consisting of essentially equimolar amounts of genomic DNA isolated from healthy human thymus, healthy human tonsil and healthy human peripheral blood mononuclear cells.

Abstract: A steel having high mechanical properties, characterized in that it has the following composition by weight: 12% to 25 % Nickel; 7.4% to 20 % Cobalt; 3% to 11% Molybdenum; 0.2% to 2.21% addition elements, the remainder being iron, the structure of the material including a combination of fine grains and ultrafine grains, the so-called fine grains having a grain size of between 1.2 micrometers and 3 micrometers and the so-called ultrafine grains having a grain size of between 0.2 and 1 micrometer, the proportion of ultrafine grains being between 55 % and 65 %, and a process for manufacturing the steel.

Abstract: The invention relates to PCR-based clonality studies for among others early diagnosis of lymphoproliferative disorders. Provided is a set of nucleic acid amplification primers comprising a forward primer, or a variant thereof, and a reverse primer, or a variant thereof, capable of amplifying a rearrangement selected from the group consisting of a VH-JH IGH rearrangement, a DH-JH IGH rearrangement, a VK-JK IGK rearrangement, a VK/intron-Kde IGK rearrangement, a V?-J? IGL rearrangement, a V?-J? TCRB rearrangement, a D?-J? TCRB rearrangement, a V?-J? TCRG rearrangement, a V?-J? TCRD rearrangement, a D?-D? TCRD rearrangement, a D?-J? TCRD rearrangement, a V?-D? TCRD rearrangement, or a translocation selected from t(11;14)(BCL1-IGH) and t(14;18)(BCL2-IGH). The primers can be used in PCR-based clonality studies for early diagnosis of lymphoproliferative disorders and detection of minimal residual disease (MRD). Also provided is a kit comprising at least one set of primers of the invention.

Abstract: In a general aspect, a method can include producing, by an inductive antenna circuit, a first periodic signal that is based on an alternating external magnetic field; producing, by an oscillator circuit, a second periodic signal that is based on the first periodic signal; and transmitting, in correspondence with a data-carrying modulation signal, a sequence of data bits. The transmitting can include sequentially and repetitively: applying, with the oscillator circuit operating in a free oscillation mode, the second periodic signal to the inductive antenna circuit; and inhibiting, with the oscillator circuit operating in a synchronous oscillation mode, application of the second periodic signal to the inductive antenna circuit. The synchronous oscillation mode of the oscillator circuit can cause the second periodic signal to be synchronized to the first periodic signal.

Abstract: A support device (20), mounted on an upper edge of a container (3), includes lifting elements that define a support surface (22) which extends transversely outwards from an inner edge (55). The upper end (2b) of a flexible pouch for biopharmaceutical product can rest on this support surface, the rest of the 3D-type pouch extending into the container. The slot (23) which separates the support surface into two portions defines a guide path for a flexible supply line (9a, 9b) for the pouch (2) that is connected at its bottom to the end (2b). A convex surface is formed at the rear end of the slot and above the edge of the container, so as to guide and facilitate the passage of the line (9a) into the housing, when the filling state is sufficiently advanced. The causes of poor deployment of the pouch are thus minimized, without human intervention.

Abstract: A method for sending data by inductive coupling includes: extracting an antenna signal from an antenna circuit, extracting from the antenna signal a first periodic signal, producing a second periodic signal by way of a synchronous oscillator, placing the oscillator in a free oscillation mode and applying to the antenna circuit the second periodic signal, modifying the impedance of the antenna circuit, restoring the amplitude of the antenna signal, then resynchronizing the oscillator on the first periodic signal.

Abstract: The invention relates to PCR-based clonality studies for among others early diagnosis of lymphoproliferative disorders. Provided is a set of nucleic acid amplification primers comprising a forward primer, or a variant thereof, and a reverse primer, or a variant thereof, capable of amplifying a rearrangement selected from the group consisting of a VH-JH IGH rearrangement, a DH-JH IGH rearrangement, a VK-J? IGK rearrangement, a VK/intron-Kde IGK rearrangement, a V?-J? IGL rearrangement, a V?-J? TCRB rearrangement, a D?-J? TCRB rearrangement, a V?-J? TCRG rearrangement, a V?-J? TCRD rearrangement, a D?-D? TCRD rearrangement, a D?-J? TCRD rearrangement, a V?-D? TCRD rearrangement, or a translocation selected from t(11;14)(BCL1-IGH) and t(14;18)(BCL2-IGH). The primers can be used in PCR-based clonality studies for early diagnosis of lymphoproliferative disorders and detection of minimal residual disease (MRD). Also provided is a kit comprising at least one set of primers of the invention.

Abstract: A coupling means (8;8?;8?,14) serves for connecting a suction channel (27) of an electrosurgical instrument (1) to a vacuum source via a suction tubing (11) and/or for guiding an electrical cable (12), that supplies electrical energy from an electrosurgical generator to the electrosurgical instrument (1). The electrosurgical instrument (1) comprises a hollow elongated main body (2) having a first end (7) for securing a first means (3) for application of the electrical energy to a surgical site and an opposite second end (9), which hollow elongated main body (2) has a switch means (5) to be operated by means of an associated actuator (4) to control application of the electrical energy to the surgical site.

Abstract: In a general aspect, a method can include producing, by an inductive antenna circuit, a first periodic signal that is based on an alternating external magnetic field; producing, by an oscillator circuit, a second periodic signal that is based on the first periodic signal; and transmitting, in correspondence with a data-carrying modulation signal, a sequence of data bits. The transmitting can include sequentially and repetitively: applying, with the oscillator circuit operating in a free oscillation mode, the second periodic signal to the inductive antenna circuit; and inhibiting, with the oscillator circuit operating in a synchronous oscillation mode, application of the second periodic signal to the inductive antenna circuit. The synchronous oscillation mode of the oscillator circuit can cause the second periodic signal to be synchronized to the first periodic signal.

Abstract: A processing receptacle for a biopharmaceutical product includes a pocket configured to accommodate the biopharmaceutical product that can assume a flat-folded state, an expanded state, or any intermediate state in between, a processing element having an active inner portion, a rigid protective chamber to protect the processing element, and at least one opening for introducing the product into the receptacle and/or for draining the contents from the receptacle. A portion of the protective chamber is rigidly attached to a portion of the pocket and movement of the pocket up or down brings about movement of the protective chamber; the processing element and the protective chamber are arranged to be independent from one another relative to their movements.

Abstract: In a general aspect, a method can include producing, by an inductive antenna circuit, a first periodic signal that is based on an alternating external magnetic field; producing, by an oscillator circuit, a second periodic signal that is based on the first periodic signal; and transmitting, in correspondence with a data-carrying modulation signal, a sequence of data bits. The transmitting can include sequentially and repetitively: applying, with the oscillator circuit operating in a free oscillation mode, the second periodic signal to the inductive antenna circuit; and inhibiting, with the oscillator circuit operating in a synchronous oscillation mode, application of the second periodic signal to the inductive antenna circuit. The synchronous oscillation mode of the oscillator circuit can cause the second periodic signal to be synchronized to the first periodic signal.

Abstract: The invention relates to a heat-exchanger for an air-conditioning circuit that includes a first pipe (110) defining a path for a flow of fluid, the first pipe being spirally wound about a so-called exchanger axis (A). According to the invention, the heat exchanger (9) further includes at least one second pipe (120a, 120b) defining a path for a flow of a second fluid, said second pipe being provided against a surface of the first pipe (110) and spirally wound together with said first pipe (110) about said axis (A). The invention can be used in air-conditioning circuits operating with a super-critical coolant, in particular carbon dioxide (CO2).

Abstract: In a general aspect, a method can include producing, by an inductive antenna circuit, a first periodic signal that is based on an alternating external magnetic field; producing, by an oscillator circuit, a second periodic signal that is based on the first periodic signal; and transmitting, in correspondence with a data-carrying modulation signal, a sequence of data bits. The transmitting can include sequentially and repetitively: applying, with the oscillator circuit operating in a free oscillation mode, the second periodic signal to the inductive antenna circuit; and inhibiting, with the oscillator circuit operating in a synchronous oscillation mode, application of the second periodic signal to the inductive antenna circuit. The synchronous oscillation mode of the oscillator circuit can cause the second periodic signal to be synchronized to the first periodic signal.

Abstract: A support device (20), mounted on an upper edge of a container (3), includes lifting elements that define a support surface (22) which extends transversely outwards from an inner edge (55). The upper end (2b) of a flexible pouch for biopharmaceutical product can rest on this support surface, the rest of the 3D-type pouch extending into the container. The slot (23) which separates the support surface into two portions defines a guide path for a flexible supply line (9a, 9b) for the pouch (2) that is connected at its bottom to the end (2b). A convex surface is formed at the rear end of the slot and above the edge of the container, so as to guide and facilitate the passage of the line (9a) into the housing, when the filling state is sufficiently advanced. The causes of poor deployment of the pouch are thus minimized, without human intervention.

Abstract: A method for sending data by inductive coupling includes: extracting an antenna signal from an antenna circuit, extracting from the antenna signal a first periodic signal, producing a second periodic signal by way of a synchronous oscillator, placing the oscillator in a free oscillation mode and applying to the antenna circuit the second periodic signal, modifying the impedance of the antenna circuit, restoring the amplitude of the antenna signal, then resynchronizing the oscillator on the first periodic signal.

Abstract: Methods of manufacturing a length of a flexible polymeric medical tubing of the kind comprising a tubing member defining a lumen, which tubing member is surrounded by spiral convolutions along at least a part of the length of the proximal section and/or the distal section, and which medical tubing has a proximal convoluted section and a distal convoluted section, is disclosed, as well as medical tubings obtained by the methods and their uses. One method comprises the steps of providing a medical tubing wherein the proximal section and the distal section have substantially uniform initial pitch (Pinitial) between adjacent convolutions, and modifying the initial pitch (Pinitial) of at least a part of the proximal section by stretching at least a part of the proximal section to achieve a modified proximal section with a proximal pitch (Pproximal) between adjacent convolutions that is larger than the initial pitch (Pinitial) between adjacent convolutions.

Abstract: A method for sending data by inductive coupling includes: extracting an antenna signal from an antenna circuit, extracting from the antenna signal a first periodic signal, producing a second periodic signal by way of a synchronous oscillator, placing the oscillator in a free oscillation mode and applying to the antenna circuit the second periodic signal, modifying the impedance of the antenna circuit, restoring the amplitude of the antenna signal, then resynchronizing the oscillator on the first periodic signal.

Abstract: The invention provides methods of treating diseases, disorsers or injuries involving demyelination and dysmyelination, including multiple sclerosis, by the administration of a Sema6A polypeptide.

Abstract: A mixing process, a spraying and dispersing device, and a mixing device for implementing the process. In the process, components are introduced into a container equipped with introduction elements and mixing elements and the contents are mixed. A mixing facilitator is provided, a spraying and dispersing device that can be connected to the container at one of its introduction element is provided, able to be in an active functional state in which it makes it possible to spray and to disperse a liquid in the container, and then, in a first phase, the base of the contents and then the components to be mixed are introduced into the container, without filling the latter, and in a second phase, the mixing facilitator is introduced into the container via an introduction element, and it is sprayed and dispersed to the components to be mixed by the spraying and dispersing device that is put into the active functional state.

Abstract: The device (1) for the sealed connection to a receptacle (2) of an accessory (3), the active proximal part (9) of which is intended to be connected to the inside (4) of the receptacle (2) by an opening (7) in the receptacle (2), includes a first element (15), a second element (16) and a chamber (18), the first element (15) including a proximal end part (32) which is secured by sliding in the proximal direction, with insertion of a lateral sealing component (22), onto a matching part (19) of the receptacle (2), in the proximal direction, the transverse head (14) corresponding to the lower surface of the first element (15) and being provided with a lateral head sealing component (28) and the second element (16) being capable of being pre-assembled with the first element (15) by axial sliding in the proximal direction.