Abstract: The invention relates to PCR-based clonality studies for among others early diagnosis of lymphoproliferative disorders. Provided is a set of nucleic acid amplification primers comprising a forward primer, or a variant thereof, and a reverse primer, or a variant thereof, capable of amplifying a rearrangement selected from the group consisting of a VH-JH IGH rearrangement, a DH-JH IGH rearrangement, a VK-JK IGK rearrangement, a VK/intron-Kde IGK rearrangement, a V?-J? IGL rearrangement, a V?-J? TCRB rearrangement, a D?-J? TCRB rearrangement, a V?-J? TCRG rearrangement, a V?-J? TCRD rearrangement, a D?-D? TCRD rearrangement, a D?-J? TCRD rearrangement, a V?-D? TCRD rearrangement, or a translocation selected from t(11;14)(BCL1-IGH) and t(14;18)(BCL2-IGH). The primers can be used in PCR-based clonality studies for early diagnosis of lymphoproliferative disorders and detection of minimal residual disease (MRD). Also provided is a kit comprising at least one set of primers of the invention.

Abstract: A support device (20), mounted on an upper edge of a container (3), includes lifting elements that define a support surface (22) which extends transversely outwards from an inner edge (55). The upper end (2b) of a flexible pouch for biopharmaceutical product can rest on this support surface, the rest of the 3D-type pouch extending into the container. The slot (23) which separates the support surface into two portions defines a guide path for a flexible supply line (9a, 9b) for the pouch (2) that is connected at its bottom to the end (2b). A convex surface is formed at the rear end of the slot and above the edge of the container, so as to guide and facilitate the passage of the line (9a) into the housing, when the filling state is sufficiently advanced. The causes of poor deployment of the pouch are thus minimized, without human intervention.

Abstract: The invention relates to PCR-based clonality studies for among others early diagnosis of lymphoproliferative disorders. Provided is a set of nucleic acid amplification primers comprising a forward primer, or a variant thereof, and a reverse primer, or a variant thereof, capable of amplifying a rearrangement selected from the group consisting of a VH-JH IGH rearrangement, a DH-JH IGH rearrangement, a VK-J? IGK rearrangement, a VK/intron-Kde IGK rearrangement, a V?-J? IGL rearrangement, a V?-J? TCRB rearrangement, a D?-J? TCRB rearrangement, a V?-J? TCRG rearrangement, a V?-J? TCRD rearrangement, a D?-D? TCRD rearrangement, a D?-J? TCRD rearrangement, a V?-D? TCRD rearrangement, or a translocation selected from t(11;14)(BCL1-IGH) and t(14;18)(BCL2-IGH). The primers can be used in PCR-based clonality studies for early diagnosis of lymphoproliferative disorders and detection of minimal residual disease (MRD). Also provided is a kit comprising at least one set of primers of the invention.

Abstract: A coupling means (8;8?;8?,14) serves for connecting a suction channel (27) of an electrosurgical instrument (1) to a vacuum source via a suction tubing (11) and/or for guiding an electrical cable (12), that supplies electrical energy from an electrosurgical generator to the electrosurgical instrument (1). The electrosurgical instrument (1) comprises a hollow elongated main body (2) having a first end (7) for securing a first means (3) for application of the electrical energy to a surgical site and an opposite second end (9), which hollow elongated main body (2) has a switch means (5) to be operated by means of an associated actuator (4) to control application of the electrical energy to the surgical site.

Abstract: A processing receptacle for a biopharmaceutical product includes a pocket configured to accommodate the biopharmaceutical product that can assume a flat-folded state, an expanded state, or any intermediate state in between, a processing element having an active inner portion, a rigid protective chamber to protect the processing element, and at least one opening for introducing the product into the receptacle and/or for draining the contents from the receptacle. A portion of the protective chamber is rigidly attached to a portion of the pocket and movement of the pocket up or down brings about movement of the protective chamber; the processing element and the protective chamber are arranged to be independent from one another relative to their movements.

Abstract: A support device (20), mounted on an upper edge of a container (3), includes lifting elements that define a support surface (22) which extends transversely outwards from an inner edge (55). The upper end (2b) of a flexible pouch for biopharmaceutical product can rest on this support surface, the rest of the 3D-type pouch extending into the container. The slot (23) which separates the support surface into two portions defines a guide path for a flexible supply line (9a, 9b) for the pouch (2) that is connected at its bottom to the end (2b). A convex surface is formed at the rear end of the slot and above the edge of the container, so as to guide and facilitate the passage of the line (9a) into the housing, when the filling state is sufficiently advanced. The causes of poor deployment of the pouch are thus minimized, without human intervention.

Abstract: Methods of manufacturing a length of a flexible polymeric medical tubing of the kind comprising a tubing member defining a lumen, which tubing member is surrounded by spiral convolutions along at least a part of the length of the proximal section and/or the distal section, and which medical tubing has a proximal convoluted section and a distal convoluted section, is disclosed, as well as medical tubings obtained by the methods and their uses. One method comprises the steps of providing a medical tubing wherein the proximal section and the distal section have substantially uniform initial pitch (Pinitial) between adjacent convolutions, and modifying the initial pitch (Pinitial) of at least a part of the proximal section by stretching at least a part of the proximal section to achieve a modified proximal section with a proximal pitch (Pproximal) between adjacent convolutions that is larger than the initial pitch (Pinitial) between adjacent convolutions.

Abstract: The invention provides methods of treating diseases, disorsers or injuries involving demyelination and dysmyelination, including multiple sclerosis, by the administration of a Sema6A polypeptide.

Abstract: A mixing process, a spraying and dispersing device, and a mixing device for implementing the process. In the process, components are introduced into a container equipped with introduction elements and mixing elements and the contents are mixed. A mixing facilitator is provided, a spraying and dispersing device that can be connected to the container at one of its introduction element is provided, able to be in an active functional state in which it makes it possible to spray and to disperse a liquid in the container, and then, in a first phase, the base of the contents and then the components to be mixed are introduced into the container, without filling the latter, and in a second phase, the mixing facilitator is introduced into the container via an introduction element, and it is sprayed and dispersed to the components to be mixed by the spraying and dispersing device that is put into the active functional state.

Abstract: The device (1) for the sealed connection to a receptacle (2) of an accessory (3), the active proximal part (9) of which is intended to be connected to the inside (4) of the receptacle (2) by an opening (7) in the receptacle (2), includes a first element (15), a second element (16) and a chamber (18), the first element (15) including a proximal end part (32) which is secured by sliding in the proximal direction, with insertion of a lateral sealing component (22), onto a matching part (19) of the receptacle (2), in the proximal direction, the transverse head (14) corresponding to the lower surface of the first element (15) and being provided with a lateral head sealing component (28) and the second element (16) being capable of being pre-assembled with the first element (15) by axial sliding in the proximal direction.

Abstract: A first piece mounted in a fixed and rigid manner on a rigid annular collar of a second piece having an end opening, includes a transversal wall; an annular wall forming a skirt, whose inner face includes a part having a larger diameter and a part having a smaller diameter; a holding toric body adjacent to the inner face, deformable between a retracted state and an expanded state, and filled with a swelling medium; and at least one inlet/outlet port for the swelling media, communicating with the holding body. The first piece is dimensioned in relation to the collar, so as to enable the first piece to be slipped onto, or removed from, the second piece, when the holding body is in the retracted state, and to be mounted onto the collar in a fixed, rigid and tight manner, when the holding body is in the expanded state.

Abstract: A processing receptacle for a biopharmaceutical product includes a pocket configured to accommodate the biopharmaceutical product that can assume a flat-folded state, an expanded state, or any intermediate state in between, a processing element having an active inner portion, a rigid protective chamber to protect the processing element, and at least one opening for introducing the product into the receptacle and/or for draining the contents from the receptacle. A portion of the protective chamber is rigidly attached to a portion of the pocket and movement of the pocket up or down brings about movement of the protective chamber; the processing element and the protective chamber are arranged to be independent from one another relative to their movements.

Abstract: Methods of manufacturing a length of a flexible polymeric medical tubing of the kind comprising a tubing member defining a lumen, which tubing member is surrounded by spiral convolutions along at least a part of the length of the proximal section and/or the distal section, and which medical tubing has a proximal convoluted section and a distal convoluted section, is disclosed, as well as medical tubings obtained by the methods and their uses. One method comprises the steps of providing a medical tubing wherein the proximal section and the distal section have substantially uniform initial pitch (Pinitial) between adjacent convolutions, and modifying the initial pitch (Pinitial) of at least a part of the proximal section by stretching at least a part of the proximal section to achieve a modified proximal section with a proximal pitch (Pproximal) between adjacent convolutions that is larger than the initial pitch (Pinitial) between adjacent convolutions.

Abstract: A vessel includes: a pocket capable of assuming a folded state and an expanded state, processing element including an active inner portion; protection element including a side wall, a lower portion and an upper portion defining an inner space, the lower portion being attached to the upper portion of the pocket, the active inner portion being provided in the inner space when the pocket is in the folded state, the peripheral portion of the inner space about the processing element defining a protection chamber; at least one insertion and/or draining opening. The active inner portion is provided inside the pocket adjacent to the lower end portion thereof, the processing element and the protection element are independent in terms of their movements, and the height of the protection chamber is variable and automatically adapts itself based on respectively, the flat-folded, unfolded and expanded states or any intermediate state of the pocket.

Abstract: A mounting assembly is provided including a first piece mounted in a fixed, detachable, and sealed manner, on a rigid, annular collar of a second piece having an end opening. The first piece includes an annular peripheral wall having an inner face configured to contact an outer face of the collar. The first piece includes a transverse wall that can enter the opening, and an annular wall forming a skirt, the inner face of the skirt including a larger diameter part, a smaller diameter part, and an intermediate part configured to contact with conjugated parts of the outer face by clamping. The transverse wall and the skirt form one component and are made of a highly flexible material enabling the first piece to be brought into an intermediate state in which the first piece is enlarged to be removed from the second piece, while retaining elastic deformation.

Abstract: An elongated electrosurgical instrument (1) serves to at least cutting and coagulating tissue of a patient during surgery by application of electrical energy supplied from an electrosurgical generator to a surgical site. The electrosurgical instrument has a hollow elongated main body with and electrode means (3). Suction means comprises a suction channel (27), a first suction port (40) facing the electrode means (3), and a second suction port (41) provided with a suction tubing (11) in communication with a vacuum source. A switch means (4) is provided on the elongated main body (2) and arranged for supplying the electrical energy to the first means (3) in response to operating an actuator (4;4?). The switch means (5) comprises at least one first electrical contact (42;43) and at least one second electrical contact (44).

Abstract: An elongated electrosurgical instrument (1) serves to at least cutting tissue of a patient during surgery by application of electrical energy supplied from an electrosurgical generator to a surgical site. The electrosurgical instrument has a hollow elongated main body (2) with an electrode means (3). Suction means comprises a suction channel (27) extending inside the hollow elongated main body (2), a first suction port (40) arranged facing the first means (3), a second suction port (41) provided with a suction tubing (11) in communication with the vacuum source, and a suction tip (6). The suction tip (6) has a coupling end part (76) that has a first engagement means (78) for engagement with a second engagement (25) means provided on the hollow elongated main body (2).

Abstract: A coupling means (8;8?;8?,14) serves for connecting a suction channel (27) of an electrosurgical instrument (1) to a vacuum source via a suction tubing (11) and/or for guiding an electrical cable (12), that supplies electrical energy from an electrosurgical generator to the electrosurgical instrument (1). The electrosurgical instrument (1) comprises a hollow elongated main body (2) having a first end (7) for securing a first means (3) for application of the electrical energy to a surgical site and an opposite second end (9), which hollow elongated main body (2) has a switch means (5) to be operated by means of an associated actuator (4) to control application of the electrical energy to the surgical site.

Abstract: An elongated electrosurgical instrument (1) comprises a first means (3) for at least cutting tissue of a patient during surgery by application of electrical energy supplied from an electrosurgical generator to a surgical site in response to operating a switch means (5). The instrument has an elongated main body (2) having a first end (7) with a first opening (15) through which the first means (3) protrudes. The first means (3) has a securing part (36) for securing to a holder (33) associated with the first end (7) of the elongated main body (2) of the electrosurgical instrument (1). The securing part (36) of the first means (3) has a first engagement part (37) of a first pentagonal cross-section, and the holder (33) includes a complementarily second engagement part (38) for receiving at least a part of the first engagement part (37).

Abstract: The device (1) for the sealed connection to a receptacle (2) of an accessory (3), the active proximal part (9) of which is intended to be connected to the inside (4) of the receptacle (2) by an opening (7) in the receptacle (2), includes a first element (15), a second element (16) and a chamber (18), the first element (15) including a proximal end part (32) which is secured by sliding in the proximal direction, with insertion of a lateral sealing component (22), onto a matching part (19) of the receptacle (2), in the proximal direction, the transverse head (14) corresponding to the lower surface of the first element (15) and being provided with a lateral head sealing component (28) and the second element (16) being capable of being pre-assembled with the first element (15) by axial sliding in the proximal direction.