Abstract: Blood typing systems and methods are provided. In one embodiment, the method may be achieved by applying a sample to a surface of a substrate having one or more binding agents immobilized thereon, wherein the one or more binding agents are capable of binding to one or more substances in the sample; substantially removing unbound material from at least a portion of the substrate having immobilized binding agent; and detecting substances bound to the one or more binding agents immobilized on the substrate; wherein the applying the sample to the surface of the substrate step is concurrent with the removing unbound material from at least a portion of the substrate step. Systems and other methods are also described and illustrated.

Abstract: Blood typing systems and methods are provided. In one embodiment, the method may be achieved by applying a sample to a surface of a substrate having one or more binding agents immobilized thereon, wherein the one or more binding agents are capable of binding to one or more substances in the sample; substantially removing unbound material from at least a portion of the substrate having immobilized binding agent; and detecting substances bound to the one or more binding agents immobilized on the substrate; wherein the applying the sample to the surface of the substrate step is concurrent with the removing unbound material from at least a portion of the substrate step. Systems and other methods are also described and illustrated.

Abstract: Blood typing systems and methods are provided. In one embodiment, the method may be achieved by applying a sample to a surface of a substrate having one or more binding agents immobilized thereon, wherein the one or more binding agents are capable of binding to one or more substances in the sample; substantially removing unbound material from at least a portion of the substrate having immobilized binding agent; and detecting substances bound to the one or more binding agents immobilized on the substrate; wherein the applying the sample to the surface of the substrate step is concurrent with the removing unbound material from at least a portion of the substrate step. Systems and other methods are also described and illustrated.

Abstract: The present disclosure relates to a device for detecting an analyte in a sample, and especially for detecting antigen/antibody reactions, wherein said device comprises a layer composed of a low-density immiscible compound. The disclosure also relates to a method for detecting an analyte in a sample and especially for detecting antigen/antibody reactions in a device comprising a layer composed of a low-density immiscible compound. The disclosure further relates to the uses of such low-density immiscible compound.

Abstract: The present disclosure relates to a device for detecting an analyte in a sample, and especially for detecting antigen/antibody reactions, wherein said device comprises a layer composed of a low-density immiscible compound. The disclosure also relates to a method for detecting an analyte in a sample and especially for detecting antigen/antibody reactions in a device comprising a layer composed of a low-density immiscible compound. The disclosure further relates to the uses of such low-density immiscible compound.

Abstract: Blood typing systems and methods are provided. In one embodiment, the method may be achieved by applying a sample to a surface of a substrate having one or more binding agents immobilized thereon, wherein the one or more binding agents are capable of binding to one or more substances in the sample; substantially removing unbound material from at least a portion of the substrate having immobilized binding agent; and detecting substances bound to the one or more binding agents immobilized on the substrate; wherein the applying the sample to the surface of the substrate step is concurrent with the removing unbound material from at least a portion of the substrate step. Systems and other methods are also described and illustrated.

Abstract: The invention relates to a method for detecting a plurality of antigenic molecules carried by erythrocytes and/or a plurality of anti-erythrocyte antibodies, said antigenic molecules carried by the erythrocytes consisting of antigenic molecules carried not only by the erythrocytes, but also by at least one other cell population, other than the blood group antigen molecules, said method comprising bringing a sample into contact with distinguishable beads, on which are attached a) antibodies specific for said antigens, or b) erythrocytes or erythrocyte membrane fragment.

Abstract: The invention relates to a method for detecting a plurality of antigenic molecules carried by erythrocytes and/or a plurality of anti-erythrocyte antibodies of an individual, comprising bringing a sample into contact with distinguishable beads, on which are attached a) antibodies specific for said antigens, or b) erythrocytes, erythrocyte membrane fragments or blood group antigens.

Abstract: The invention relates to a device for filling at least one receptacle (12) of gel card type initially sealed by a cap. The invention is characterized by the fact that the filling device comprises a piercing member (110) for perforating the cap, means (120) for eliminating the electrostatic charges capable of being borne by the receptacle, and filling means (130) for filling the receptacle after perforation of the cap and elimination of the electrostatic charges.

Abstract: The invention relates to a method for detecting a plurality of antigenic molecules carried by erythrocytes and/or a plurality of anti-erythrocyte antibodies, said antigenic molecules carried by the erythrocytes consisting of antigenic molecules carried not only by the erythrocytes, but also by at least one other cell population, other than the blood group antigen molecules, said method comprising bringing a sample into contact with distinguishable beads, on which are attached a) antibodies specific for said antigens, or b) erythrocytes or erythrocyte membrane fragment.

Abstract: The invention relates to a method for detecting a plurality of antigenic molecules carried by erythrocytes and/or a plurality of anti-erythrocyte antibodies of an individual, comprising bringing a sample into contact with distinguishable beads, on which are attached a) antibodies specific for said antigens, or b) erythrocytes, erythrocyte membrane fragments or blood group antigens.

Abstract: The invention concerns a barrier (2) temporarily separating a reaction container (1) into at least a first compartment (3) wherein a reaction medium comprising an analyte and optionally a reagent is introduced and a second compartment (4) for receiving at least one of the elements among the reagent, the analyte and the reaction product, said barrier (2) being made of a material adapted to shift, by the action of a specific chemical substance, from a first state wherein said material is substantially impermeable to the reaction medium to a second state wherein said material is capable of allowing through at least one of said elements among the reagent, the analyte and the reaction product. The invention also concerns a container comprising such a barrier and a method for carrying out an assay in said container.

Abstract: The invention concerns a biological assay device using a reaction between an analyte present in a fluid and a reagent capable of forming a complex with said analyte, wherein the analyte is in the form of cellular elements, said device comprising at least a reaction container (1) provided with a reaction zone (2) wherein are introduced the fluid and the reagent, and with an immobilizing zone (3) whereon is fixed a substance (4) capable of specifically binding with the possibly formed complexes, the reaction zone (2) and the immobilizing zone (3) being separated from each other by a material layer (8), said material being capable of shifting from one first state wherein the layer (8) is substantially impermeable to a second state wherein the layer (8) is capable of allowing through the cellular elements, whether complexed or not.

Abstract: The invention concerns a method for magnetising chemical or biological markers using magnetic particles, said method comprising steps which consist in: activating the magnetic particles so as to modify their surface state; contacting the activated magnetic particles with the markers so as to produce non-specific bonds between them. The invention also concerns the use of biological markers magnetised by said method as reagents or analytes in a biological assay.