Patents by Inventor Frederic Chaubet
Frederic Chaubet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11154625Abstract: The present invention relates to the diagnosis of clinical conditions characterized by undesirable and/or abnormal selectin expression. In particular, the invention provides for the use of fucoidans for the detection of selectins using imaging techniques including ultrasonography, scintigraphy and MRI. Selectin-targeted imaging agents are provided that comprise at least one fucoidan moiety associated with at least one detectable moiety. Methods and kits are described for using these imaging agents in the diagnosis of clinical conditions such as thrombosis, myocardial ischemia/reperfusion injury, stroke and ischemic brain trauma, neurodegenerative disorders, tumor metastasis and tumor growth, and rheumatoid arthritis.Type: GrantFiled: January 17, 2014Date of Patent: October 26, 2021Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE PARIS 13Inventors: Jean-Baptiste Michel, Didier Letourneur, Frederic Chaubet, Laure Bachelet, Francois Rouzet, Alain Meulemans
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Patent number: 9999679Abstract: The invention relates to a vector targeting thrombus, having t-PA binding property consisting of a thrombus targeting fucoidan moiety, which is covalently linked to one or more t-PA binding amino groups by the reducing end of the said fucoidan moiety.Type: GrantFiled: March 21, 2014Date of Patent: June 19, 2018Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE PARIS XIII PARIS NORD, UNIVERSITE PARIS DIDEROT—PARIS 7Inventors: Stephane Loyau, Martine Jandrot-Perrus, Didier Letourneur, Frederic Chaubet, Benoit Ho-Tin-Noe, Murielle Maire, Jean-Baptiste Michel
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Patent number: 9555164Abstract: The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprise the steps consisting of a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide and one cross-linking agent b) freezing the aqueous solution of step a) c) sublimating the frozen solution of step b) characterized in that step b) is performed before the cross-linking of the polysaccharide occurs in the solution of step a).Type: GrantFiled: May 11, 2015Date of Patent: January 31, 2017Assignee: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)Inventors: Catherine Le Visage, Didier Letourneur, Frederic Chaubet, Aude Autissier
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Publication number: 20160279249Abstract: The invention relates to a vector targeting thrombus, having t-PA binding property consisting of a thrombus targeting fucoidan moiety, which is covalently linked to one or more t-PA binding amino groups by the reducing end of the said fucoidan moiety.Type: ApplicationFiled: March 21, 2014Publication date: September 29, 2016Applicants: INSTITUT DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE PARIS XIII PARIS NORD, UNIVERSITE PARIS DIDEROT - PARIS 7Inventors: Stephane LOYAU, Martine JANDROT-PERRUS, Didier LETOURNEUR, Frederic CHAUBET, Benoit HO-TIN-NOE, Murielle MAIRE, Jean-Baptiste MICHEL
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Publication number: 20150246163Abstract: The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprise the steps consisting of a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide and one cross-linking agent b) freezing the aqueous solution of step a) c) sublimating the frozen solution of step b) characterized in that step b) is performed before the cross-linking of the polysaccharide occurs in the solution of step a).Type: ApplicationFiled: May 11, 2015Publication date: September 3, 2015Inventors: Catherine Le Visage, Didier Letourneur, Frederic Chaubet, Aude Autissier
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Patent number: 9028857Abstract: The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprise the steps consisting of a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide and one cross-linking agent b) freezing the aqueous solution of step a) c) sublimating the frozen solution of step b). characterized in that step b) is performed before the cross-linking of the polysaccharide occurs in the solution of step a).Type: GrantFiled: October 10, 2008Date of Patent: May 12, 2015Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), Universite Paris 7—Denis DiderotInventors: Catherine Le Visage, Didier Letourneur, Frederic Chaubet, Aude Autissier
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Publication number: 20140134102Abstract: The present invention relates to the diagnosis of clinical conditions characterized by undesirable and/or abnormal selectin expression. In particular, the invention provides for the use of fucoidans for the detection of selectins using imaging techniques including ultrasonography, scintigraphy and MRI. Selectin-targeted imaging agents are provided that comprise at least one fucoidan moiety associated with at least one detectable moiety. Methods and kits are described for using these imaging agents in the diagnosis of clinical conditions such as thrombosis, myocardial ischemia/reperfusion injury, stroke and ischemic brain trauma, neurodegenerative disorders, tumor metastasis and tumor growth, and rheumatoid arthritis.Type: ApplicationFiled: January 17, 2014Publication date: May 15, 2014Applicant: INSERM (Institut National de la Sante et de la Recherche Medicale)Inventors: Jean-Baptiste Michel, Didier Letourneur, Frederic Chaubet, Laure Bachelet, Francois Rouzet, Alain Meulemans
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Publication number: 20120183475Abstract: The present invention relates to the diagnosis of clinical conditions characterized by undesirable and/or abnormal selectin expression. In particular, the invention provides for the use of fucoidans for the detection of selectins using imaging techniques including ultrasonography, scintigraphy and MRI. Selectin-targeted imaging agents are provided that comprise at least one fucoidan moiety associated with at least one detectable moiety. Methods and kits are described for using these imaging agents in the diagnosis of clinical conditions such as thrombosis, myocardial ischemia/reperfusion injury, stroke and ischemic brain trauma, neurodegenerative disorders, tumor metastasis and tumor growth, and rheumatoid arthritis.Type: ApplicationFiled: January 9, 2012Publication date: July 19, 2012Applicant: INSERM (Institut National de la sante et de la Recherche Medicale)Inventors: Jean-Baptiste Michel, Didier Letourneur, Frederic Chaubet, Laure Bachelet, Francois Rouzet, Alain Meulemans
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Publication number: 20120093725Abstract: The present invention relates to the diagnosis of clinical conditions characterized by undesirable and/or abnormal selectin expression. In particular, the invention provides for the use of fucoidans for the detection of selectins using imaging techniques including ultrasonography, scintigraphy and MRI. Selectin-targeted imaging agents are provided that comprise at least one fucoidan moiety associated with at least one detectable moiety. Methods and kits are described for using these imaging agents in the diagnosis of clinical conditions such as thrombosis, myocardial ischemia/reperfusion injury, stroke and ischemic brain trauma, neurodegenerative disorders, tumor metastasis and tumor growth, and rheumatoid arthritis.Type: ApplicationFiled: April 10, 2009Publication date: April 19, 2012Applicant: Inserm (Institut National de la Sante et de la Recherche MedicaleInventors: Jean-Baptiste Michel, Didier Letourneur, Frederic Chaubet, Laure Bachelet, Francois Rouzet, Alain Meulemans
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Publication number: 20100221301Abstract: The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprise the steps consisting of a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide and one cross-linking agent b) freezing the aqueous solution of step a) c) sublimating the frozen solution of step b). characterized in that step b) is performed before the cross-linking of the polysaccharide occurs in the solution of step a).Type: ApplicationFiled: October 10, 2008Publication date: September 2, 2010Applicants: UNIVERSITE PARIS 7 - DENIS DIDEROT, RECHERCHE MEDICALE)Inventors: Catherine Le Visage, Didier Letourneur, Frederic Chaubet, Aude Autissier
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Patent number: 6946443Abstract: The invention concerns a biologically active material essentially comprising at least an insolubilized dextran derivative of general formula DMCaBbSUcSd and at least a growth factor having an activity on osteoarticular, dental and/or maxillofacial tissues, and the method for preparing same. The invention also concerns the uses of said biomaterial for preparing a repair or filing material, such as an implant, for osteoarticular, dental or maxillofacial applications and for preparing an orthopaedic, dental or maxillofacial prosthesis, and the prosthesis coated with said biologically active material.Type: GrantFiled: December 11, 2001Date of Patent: September 20, 2005Assignee: BiodexInventors: Cinderella Blanchat, Delphine Logeart-Avramoglou, Hervé Petite, Alain Meunier, Frédéric Chaubet, Jacqueline Jozefonvicz, Marcel Jozefowicz, Laurent Sedel, José Correia
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Patent number: 6646120Abstract: The invention concerns dextran derivatives, their applications as medicines with specific biological action, and their preparation method. Said derivatives correspond to the general formula DMCaBbSUcSd, in which: D represents a polysaccharide chain, preferably consisting of sequences of glucoside units, MC represents methylcarboxylate groups, B represents carboxymethylbenzylamide groups, Su represents sulphate groups, S represents sulphonate groups, a, b, c and d represent the degree of substitution (ds), respectively in groups, MC, B, Su and S; a being equal to 0 or ≧0.3, b being equal to 0 or ≧0.1, c being equal to 0 or ≧0.1 and d being equal to 0 or ≧0.Type: GrantFiled: September 26, 2000Date of Patent: November 11, 2003Assignee: BiodexInventors: Frederic Chaubet, Remi Huynh, Latifa Dahri, Jose Correia, Marcel Jozefowicz, Jacqueline Jozefonvicz
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Publication number: 20030171333Abstract: The invention concerns a pharmaceutical composition containing at least a polymer associated or conjugated with at least a phenylalkylcarboxylic acid derivative, novel polymers conjugated with at least a phenylalkylcarboxylic acid derivative and their uses in particular in cancer treatment.Type: ApplicationFiled: May 2, 2003Publication date: September 11, 2003Inventors: Thierry Avramoglou, Rosita Bagheri, Frederic Chaubet, Michel Crepin, Latifa Dahri, Melanie Dibenedetto, Claudia Gervelas, Remi Huynh, Jacqueline Jozefonvicz
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Publication number: 20020169120Abstract: The invention concerns a biologically active material essentially comprising at least an insolubilised dextran derivative of general formula DMCaBbSUcSd and at least a growth factor having an activity on osteoarticular, dental and/or maxillofacial tissues, and the method for preparing same. The invention also concerns the uses of said biomaterial for preparing a repair or filing material, such as an implant, for osteoarticular, dental or maxillofacial applications and for preparing an orthopaedic, dental or maxillofacial prosthesis, and the prosthesis coated with said biologically active material.Type: ApplicationFiled: December 11, 2001Publication date: November 14, 2002Inventors: Cinderella Blanchat, Delphine Logeart-Avramoglou, Herve Petite, Alain Meunier, Frederic Chaubet, Jacqueline Jozefonvicz, Marcel Jozefowicz, Laurent Sedel, Jose Correia
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Patent number: 6028191Abstract: A method for obtaining sulphated polysaccharides using the free radical depolymerization of a fucan from Phaeophyceae in the presence of a metal catalyst and of hydrogen peroxide is described. The method of the invention provides polysaccharide fractions with a molecular weight of 10,000 g/mol or less, with anticoagulant properties.Type: GrantFiled: May 6, 1998Date of Patent: February 22, 2000Assignees: Centre National de la Recherche Scientifique (CNRS), Institut Francais de Recherche Pour L'Exploitation de la Mer (Ifremer)Inventors: Alain Nardella, Frederic Chaubet, Corinne Sinquin, Sylvia Colliec Jouault, Catherine Boisson-Vidal, Patrick Durand, Jacqueline Jozefonvicz