Patents by Inventor Frederic Dixon Bushman

Frederic Dixon Bushman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CAR T CELL THERAPIES WITH ENHANCED EFFICACY
    Publication number: 20240076372
    Abstract: The invention provides methods for manufacturing optimized CAR T cell therapies and uses thereof. Specifically, the invention provides parameters that can be measured, e.g., evaluated, to manufacture CAR T cell therapies with optimized properties. The invention further provides methods of use in connection with said optimized CAR T cells.
    Type: Application
    Filed: March 6, 2023
    Publication date: March 7, 2024
    Inventors: Christopher Loren Nobles, Frederic Dixon Bushman, Joseph A. Fraietta, Simon Lacey, Jan J. Melenhorst, Carl H. June
  • CAR T CELL THERAPIES WITH ENHANCED EFFICACY
    Publication number: 20230139800
    Abstract: The invention provides compositions and methods improved CAR T cell therapies. Specifically, the invention provides cells with reduced Tet, e.g., Tet2 function or expression, and methods of use therefore. The invention further provides Tet2 inhibitors and methods of use therefore in connection with CAR T cells.
    Type: Application
    Filed: September 20, 2022
    Publication date: May 4, 2023
    Inventors: Gregory Motz, Frederic Dixon Bushman, Joseph A. Fraietta, Carl H. June, Jan J. Melenhorst, Christopher Loren Nobles, Regina M. Young
  • CAR T CELL THERAPIES WITH ENHANCED EFFICACY
    Publication number: 20210047405
    Abstract: The invention provides methods for manufacturing optimized CAR T cell therapies and uses thereof. Specifically, the invention provides parameters that can be measured, e.g., evaluated, to manufacture CAR T cell therapies with optimized properties. The invention further provides methods of use in connection with said optimized CART cells.
    Type: Application
    Filed: April 26, 2019
    Publication date: February 18, 2021
    Inventors: Christopher Loren Nobles, Frederic Dixon Bushman, Joseph A. Fraietta, Simon Lacey, Jan J. Melenhorst, Carl H. June
  • CAR T CELL THERAPIES WITH ENHANCED EFFICACY
    Publication number: 20180258149
    Abstract: The invention provides compositions and methods improved CAR T cell therapies. Specifically, the invention provides cells with reduced Tet, e.g., Tet2 function or expression, and methods of use therefore. The invention further provides Tet2 inhibitors and methods of use therefore in connection with CAR T cells.
    Type: Application
    Filed: September 16, 2016
    Publication date: September 13, 2018
    Applicants: Novartis AG, The Trustees of the University of Pennsylvania
    Inventors: Gregory Motz, Frederic Dixon Bushman, Joseph A. Fraietta, Carl H. June, Jan J. Melenhorst, Christopher Loren Nobles, Regina M. Young