Patents by Inventor Frederic Domergue
Frederic Domergue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11952581Abstract: The present invention relates to a process for the production of polyunsaturated fatty acids in an organism by introducing, into the organism, nucleic acids which encode polypeptides with ?5-elongase activity. Advantageously, these nucleic acids can be expressed in the organism together with further nucleic acids which encode polypeptides of the biosynthesis of the fatty acid or lipid metabolism. Especially advantageous are nucleic acids which encode ?6-desaturases, ?5-desaturases, ?4-desaturases and/or ?6-elongases. These desaturases and elongases are advantageously derived from Thalassiosira, Euglena or Ostreococcus. The invention furthermore relates to a process for the production of oils and/or triacylglycerides with an elevated content of long-chain polyunsaturated fatty acids, and oils and/or triacylglycerides thus obtained.Type: GrantFiled: November 22, 2021Date of Patent: April 9, 2024Assignee: BASF PLANT SCIENCE GMBHInventors: Thorsten Zank, Jörg Bauer, Petra Cirpus, Amine Abbadi, Ernst Heinz, Xiao Qiu, Patricia Vrinten, Petra Sperling, Frederic Domergue, Astrid Schmidt, Helene Kirsch
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Publication number: 20220162629Abstract: The present invention relates to a process for the production of polyunsaturated fatty acids in an organism by introducing, into the organism, nucleic acids which encode polypeptides with ?5-elongase activity. Advantageously, these nucleic acids can be expressed in the organism together with further nucleic acids which encode polypeptides of the biosynthesis of the fatty acid or lipid metabolism. Especially advantageous are nucleic acids which encode ?6-desaturases, ?5-desaturases, ?4-desaturases and/or ?6-elongases. These desaturases and elongases are advantageously derived from Thalassiosira, Euglena or Ostreococcus. The invention furthermore relates to a process for the production of oils and/or triacylglycerides with an elevated content of long-chain polyunsaturated fatty acids, and oils and/or triacylglycerides thus obtained.Type: ApplicationFiled: November 22, 2021Publication date: May 26, 2022Inventors: Thorsten Zank, Jörg Bauer, Petra Cirpus, Amine Abbadi, Ernst Heinz, Xiao Qiu, Patricia Vrinten, Petra Sperling, Frederic Domergue, Astrid Schmidt, Helene Kirsch
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Patent number: 11180769Abstract: The present invention relates to a process for the production of polyunsaturated fatty acids in an organism by introducing, into the organism, nucleic acids which encode polypeptides with ?5-elongase activity. Advantageously, these nucleic acids can be expressed in the organism together with further nucleic acids which encode polypeptides of the biosynthesis of the fatty acid or lipid metabolism. Especially advantageous are nucleic acids which encode ?6-desaturases, ?5-desaturases, ?4-desaturases and/or ?6-elongases. These desaturases and elongases are advantageously derived from Thalassiosira, Euglena or Ostreococcus. The invention furthermore relates to a process for the production of oils and/or triacylglycerides with an elevated content of long-chain polyunsaturated fatty acids, and oils and/or triacylglycerides thus obtained.Type: GrantFiled: July 11, 2019Date of Patent: November 23, 2021Assignee: BASF PLANT SCIENCE GMBHInventors: Thorsten Zank, Jörg Bauer, Petra Cirpus, Amine Abbadi, Ernst Heinz, Xiao Qiu, Patricia Vrinten, Petra Sperling, Frederic Domergue, Astrid Schmidt, Helene Kirsch
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Publication number: 20190323024Abstract: The present invention relates to a process for the production of polyunsaturated fatty acids in an organism by introducing, into the organism, nucleic acids which encode polypeptides with ?5-elongase activity. Advantageously, these nucleic acids can be expressed in the organism together with further nucleic acids which encode polypeptides of the biosynthesis of the fatty acid or lipid metabolism. Especially advantageous are nucleic acids which encode ?6-desaturases, ?5-desaturases, ?4-desaturases and/or ?6-elongases. These desaturases and elongases are advantageously derived from Thalassiosira, Euglena or Ostreococcus. The invention furthermore relates to a process for the production of oils and/or triacylglycerides with an elevated content of long-chain polyunsaturated fatty acids, and oils and/or triacylglycerides thus obtained.Type: ApplicationFiled: July 11, 2019Publication date: October 24, 2019Inventors: Thorsten ZANK, Jörg BAUER, Petra CIRPUS, Amine ABBADI, Ernst HEINZ, Xiao QIU, Patricia VRINTEN, Petra SPERLING, Frederic DOMERGUE, Astrid SCHMIDT, Helene KIRSCH
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Publication number: 20170016015Abstract: The present invention relates to a process for the production of polyunsaturated fatty acids in an organism by introducing, into the organism, nucleic acids which encode polypeptides with ?5-elongase activity. Advantageously, these nucleic acids can be expressed in the organism together with further nucleic acids which encode polypeptides of the biosynthesis of the fatty acid or lipid metabolism. Especially advantageous are nucleic acids which encode ?6-desaturases, ?5-desaturases, ?4-desaturases and/or ?6-elongases. These desaturases and elongases are advantageously derived from Thalassiosira, Euglena or Ostreococcus. The invention furthermore relates to a process for the production of oils and/or triacylglycerides with an elevated content of long-chain polyunsaturated fatty acids, and oils and/or triacylglycerides thus obtained.Type: ApplicationFiled: August 16, 2016Publication date: January 19, 2017Inventors: Thorsten Zank, Jörg Bauer, Petra Cirpus, Amine Abbadi, Ernst Heinz, Xiao Qiu, Patricia Vrinten, Petra Sperling, Frederic Domergue, Astrid Meyer, Jelena Kirsch
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Patent number: 9433228Abstract: The invention relates to a method for the production of multiply-unsaturated fatty acids in an organism, into which nucleic acids have been introduced, which code for polypeptides with ?-5 elongase activity. Said nucleic acid sequences, optionally with further nucleic acid sequences, coding for polypeptides for the biosynthesis of fatty acids and lipid metabolism, are advantageously expressed in the organism. Nucleic acid sequences coding for a ?-6 desaturase, a ?-5 desaturase, ?-4 desaturase and/or ?-6 elongase activity are particularly advantageous and, advantageously, said saturases and elongases are derived from Thalassiosira, Euglena or Ostreococcus. The invention further relates to a method for the production of oils and/or triacylglycerides with an increased content of long-chain, multiply-unsaturated fatty acids.Type: GrantFiled: July 16, 2004Date of Patent: September 6, 2016Assignee: BASF Plant Science GmbHInventors: Thorsten Zank, Jörg Bauer, Petra Cirpus, Amine Abbadi, Ernst Heinz, Xiao Qiu, Patricia Vrinten, Petra Sperling, Frederic Domergue, Astrid Meyer, Jelena Kirsch
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Patent number: 8729337Abstract: The present invention relates to a method for the production of unsaturated fatty acids with at least two double bonds. The invention furthermore relates to the use of nucleic acid sequences SEQ ID NO: 1, 3, 5, 9, and 11 encoding polypeptides having desaturase or elongase activity in the method and for generating a transgenic organism, preferably a transgenic plant or a transgenic microorganism, with an increased content of fatty acids, oils or lipids with unsaturated C18-, C20-, or C22-fatty acids, and to their homologs or derivatives, to gene constructs encompassing these genes, and to their use alone or in combination with biosynthesis genes of polyunsaturated fatty acids. The invention also relates to multiexpression cassettes for seed-specific expression, and to vectors or organisms which encompass a desaturase gene alone or in combination with further desaturases and/or elongase genes or homologs using said expression cassettes.Type: GrantFiled: January 2, 2012Date of Patent: May 20, 2014Assignee: BASF Plant Science GmbHInventors: Jens Lerchl, Andreas Renz, Ernst Heinz, Frederic Domergue, Ulrich Zähringer
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Publication number: 20140026259Abstract: The present invention relates to a process for producing polyunsaturated fatty acids in an organism by introducing nucleic acids into the organism which code for polypeptides having acyl-CoA:lysophospholipid a cyltransferase activity. Advantageously, these nucleic acid sequences may, if appropriate together with further nucleic acid sequences coding for biosynthesis polypeptides of the fatty acid or lipid metabolism, be expressed in the transgenic organism. The invention furthermore relates to the nucleic acid sequences, to nucleic acid constructs comprising the nucleic acid sequences of the invention, to vectors comprising the nucleic acid sequences and/or the nucleic acid constructs and to transgenic organisms comprising the abovementioned nucleic acid sequences, nucleic acid constructs and/or vectors. A further part of the invention relates to oils, lipids and/or fatty acids produced by the process of the invention and to their use.Type: ApplicationFiled: June 7, 2013Publication date: January 23, 2014Inventors: Andreas Renz, Ernst Heinz, Amine Abbadi, Frederic Domergue, Thorsten Zank
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Patent number: 8486671Abstract: The present invention relates to a process for producing polyunsaturated fatty acids in an organism by introducing nucleic acids into the organism which code for polypeptides having acyl-CoA:lysophospholipid a cyltransferase activity. Advantageously, these nucleic acid sequences may, if appropriate together with further nucleic acid sequences coding for biosynthesis polypeptides of the fatty acid or lipid metabolism, be expressed in the transgenic organism. The invention furthermore relates to the nucleic acid sequences, to nucleic acid constructs comprising the nucleic acid sequences of the invention, to vectors comprising the nucleic acid sequences and/or the nucleic acid constructs and to transgenic organisms comprising the abovementioned nucleic acid sequences, nucleic acid constructs and/or vectors. A further part of the invention relates to oils, lipids and/or fatty acids produced by the process of the invention and to their use.Type: GrantFiled: April 2, 2009Date of Patent: July 16, 2013Assignee: BASF Plant Science GmbHInventors: Andreas Renz, Ernst Heinz, Amine Abbadi, Frederic Domergue, Thorsten Zank
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Publication number: 20120210465Abstract: The present invention relates to a method for the production of unsaturated fatty acids with at least two double bonds. The invention furthermore relates to the use of nucleic acid sequences SEQ ID NO: 1, 3, 5, 9, and 11 encoding polypeptides having desaturase or elongase activity in the method and for generating a transgenic organism, preferably a transgenic plant or a transgenic microorganism, with an increased content of fatty acids, oils or lipids with unsaturated C18-, C20-, or C22-fatty acids, and to their homologs or derivatives, to gene constructs encompassing these genes, and to their use alone or in combination with biosynthesis genes of polyunsaturated fatty acids. The invention also relates to multiexpression cassettes for seed-specific expression, and to vectors or organisms which encompass a desaturase gene alone or in combination with further desaturases and/or elongase genes or homologs using said expression cassettes.Type: ApplicationFiled: January 2, 2012Publication date: August 16, 2012Applicant: BASF Plant Science GmbHInventors: Jens Lerchl, Andreas Renz, Ernst Heinz, Frederic Domergue, Ulrich Zähringer
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Patent number: 8088974Abstract: The present invention relates to a method for the production of unsaturated fatty acids with at least two double bonds. The invention furthermore relates to the use of nucleic acid sequences SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5 and SEQ ID NO: 11 encoding polypeptides having desaturase activity in the method and for generating a transgenic organism, preferably a transgenic plant or a transgenic microorganism, with an increased content of fatty acids, oils or lipids with unsaturated C18-, C20-, or C22-fatty acids, and to their homologs or derivatives, to gene constructs encompassing these genes, and to their use alone or in combination with biosynthesis genes of polyunsaturated fatty acids. The invention also relates to multiexpression cassettes for seed-specific expression, and to vectors or organisms which encompass a desaturase gene alone or in combination with further desaturases and/or elongase genes or homologs using said expression cassettes.Type: GrantFiled: September 24, 2009Date of Patent: January 3, 2012Assignee: BASF Plant Science GmbHInventors: Jens Lerchl, Andreas Renz, Ernst Heinz, Frederic Domergue, Ulrich Zähringer
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Publication number: 20100021976Abstract: The present invention relates to a method for the production of unsaturated fatty acids with at least two double bonds. The invention furthermore relates to the use of nucleic acid sequences SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5 and SEQ ID NO: 11 encoding polypeptides having desaturase activity in the method and for generating a transgenic organism, preferably a transgenic plant or a transgenic microorganism, with an increased content of fatty acids, oils or lipids with unsaturated C18-, C20-, or C22-fatty acids, and to their homologs or derivatives, to gene constructs encompassing these genes, and to their use alone or in combination with biosynthesis genes of polyunsaturated fatty acids. The invention also relates to multiexpression cassettes for seed-specific expression, and to vectors or organisms which encompass a desaturase gene alone or in combination with further desaturases and/or elongase genes or homologs using said expression cassettes.Type: ApplicationFiled: September 24, 2009Publication date: January 28, 2010Applicant: BASF Plant Science GmbHInventors: Jens Lerchl, Andreas Renz, Ernst Heinz, Frederic Domergue, Ulrich Zahringer
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Patent number: 7615679Abstract: The present invention relates to a method for the production of unsaturated fatty acids with at least two double bonds. The invention further relates to the use of the nucleic acid sequence of SEQ ID NO: 1 encoding a polypeptide having delta-5 desaturase activity in the method and for generating a transgenic organism, preferably a transgenic plant or microorganism with an increased content of fatty acids, oil or lipids with unsaturated long chain fatty acids, to their homologs or derivatives, and to gene constructs encompassing these genes. The invention also relates to the use of the nucleic acid sequences alone or in combination with further desaturases and/or elongase genes in the method and for generating transgenic organisms.Type: GrantFiled: January 18, 2002Date of Patent: November 10, 2009Assignee: BASF Plant Science GmbHInventors: Jens Lerchl, Andreas Renz, Ernst Heinz, Frederic Domergue, Ulrich Zähringer
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Publication number: 20090209774Abstract: The present invention relates to a process for producing polyunsaturated fatty acids in an organism by introducing nucleic acids into the organism which code for polypeptides having acyl-CoA:lysophospholipid a cyltransferase activity. Advantageously, these nucleic acid sequences may, if appropriate together with further nucleic acid sequences coding for biosynthesis polypeptides of the fatty acid or lipid metabolism, be expressed in the transgenic organism. The invention furthermore relates to the nucleic acid sequences, to nucleic acid constructs comprising the nucleic acid sequences of the invention, to vectors comprising the nucleic acid sequences and/or the nucleic acid constructs and to transgenic organisms comprising the abovementioned nucleic acid sequences, nucleic acid constructs and/or vectors. A further part of the invention relates to oils, lipids and/or fatty acids produced by the process of the invention and to their use.Type: ApplicationFiled: April 2, 2009Publication date: August 20, 2009Applicant: BASF Plant Science GmbHInventors: Andreas Renz, Ernst Heinz, Amine Abbadi, Frederic Domergue, Thorsten Zank
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Patent number: 7537920Abstract: The present invention relates to a process for producing polyunsaturated fatty acids in an organism by introducing nucleic acids into the organism which code for polypeptides having acyl-CoA:lysophospholipid a cyltransferase activity. Advantageously, these nucleic acid sequences may, if appropriate together with further nucleic acid sequences coding for biosynthesis polypeptides of the fatty acid or lipid metabolism, be expressed in the transgenic organism. The invention furthermore relates to the nucleic acid sequences, to nucleic acid constructs comprising the nucleic acid sequences of the invention, to vectors comprising the nucleic acid sequences and/or the nucleic acid constructs and to transgenic organisms comprising the abovementioned nucleic acid sequences, nucleic acid constructs and/or vectors. A further part of the invention relates to oils, lipids and/or fatty acids produced by the process of the invention and to their use.Type: GrantFiled: January 29, 2004Date of Patent: May 26, 2009Assignee: BASF Plant Science GmbHInventors: Andreas Renz, Ernst Heinz, Amine Abbadi, Frederic Domergue, Thorsten Zank
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Publication number: 20080155705Abstract: The invention relates to a method for the production of multiply-unsaturated fatty acids in an organism, into which nucleic acids have been introduced, which code for polypeptides with ?-5 elongase activity. Said nucleic acid sequences, optionally with further nucleic acid sequences, coding for polypeptides for the biosynthesis of fatty acids and lipid metabolism, are advantageously expressed in the organism. Nucleic acid sequences coding for a ?-6 desaturase, a ?-5 desaturase, ?-4 desaturase and/or ?-6 elongase activity are particularly advantageous and, advantageously, said saturases and elongases are derived from Thalassiosira, Euglena or Ostreococcus. The invention further relates to a method for the production of oils and/or triacylglycerides with an increased content of long-chain, multiply-unsaturated fatty acids.Type: ApplicationFiled: July 16, 2004Publication date: June 26, 2008Applicant: BASF Plant Science GmbHInventors: Thorsten Zank, Jorg Bauer, Petra Cirpus, Amine Abbadi, Ernst Heinz, Xiao Qiu, Patricia Vrinten, Petra Sperling, Frederic Domergue, Astrid Meyer, Jelena Kirsch
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Publication number: 20080076166Abstract: The present invention relates to a process for the production of polyunsaturated fatty acids in an organism by introducing, into the organism, nucleic acids which encode polypeptides with ?5-elongase, ?6-desaturase, ?5-desaturase, ?4-desaturase, ?12-desaturase and/or ?6-elongase activity. These desaturases and elongases are advantageously derived from Ostreococcus. The invention furthermore relates to a process for the production of oils and/or triacylglycerides with an elevated content of long-chain polyunsaturated fatty acids. The invention furthermore relates to the nucleic acid sequences, nucleic acid constructs, vectors and organisms comprising the nucleic acid sequences according to the invention, to vectors comprising the nucleic acid sequences and/or the nucleic acid constructs and to transgenic organisms comprising the abovementioned nucleic acid sequences, nucleic acid constructs and/or vectors.Type: ApplicationFiled: December 21, 2005Publication date: March 27, 2008Applicant: BASF PLANT SCIENCE GMBHInventors: Petra Cirpus, Jorg Bauer, Ernst Heinz, Frederic Domergue
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Publication number: 20060168687Abstract: The present invention relates to a process for producing polyunsaturated fatty acids in an organism by introducing nucleic acids into said organism which code for polypeptides having acyl-CoA:lysophospholipid acyltransferase activity. Advantageously, these nucleic acid sequences may, if appropriate together with further nucleic acid sequences coding for biosynthesis polypeptides of the fatty acid or lipid metabolism, be expressed in the transgenic organism. The invention furthermore relates to the nucleic acid sequences, to nucleic acid constructs comprising the nucleic acid sequences of the invention, to vectors comprising said nucleic acid sequences and/or said nucleic acid constructs and to transgenic organisms comprising the abovementioned nucleic acid sequences, nucleic acid constructs and/or vectors. A further part of the invention relates to oils, lipids and/or fatty acids produced by the process of the invention and to their use.Type: ApplicationFiled: January 29, 2004Publication date: July 27, 2006Applicant: BASF Plant Science GmbHInventors: Andreas Renz, Ernst Heinz, Amine Abbadi, Frederic Domergue, Thorsten Zank
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Publication number: 20040053379Abstract: The present invention relates to a method for the production of unsaturated fatty acids with at least two double bonds and/or a method for the production of triglycerides with an increased content of polyunsaturated fatty acids with at least two double bonds. The invention furthermore relates to the advantageous use of the nucleic acid sequences SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 9, SEQ ID NO: 11 or SEQ ID NO: 18 in the method and for generating a transgenic organism, preferably a transgenic plant or a transgenic microorganism, with an increased content of fatty acids, oils or lipids with unsaturated C18-, C20-, or C22-fatty acids.Type: ApplicationFiled: July 2, 2003Publication date: March 18, 2004Inventors: Jens Lerchl, Andreas Renz, Ernst Heinz, Frederic Domergue, Ulrich Zahringer