Patents by Inventor Frederic Duconge

Frederic Duconge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNA APTAMERS SPECIFIC FOR A-SYNUCLEIN PROTEIN FIBER CONFORMERS
    Publication number: 20240240191
    Abstract: The present invention relates to an aptamer characterized in that it has the ability to distinguish conformers of F-type ?-Syn fibres of the ?-Syn (?-Syn) protein from conformers of R-type ?-Syn fibres, and in that it comprises a sequence specific for modified ribonucleic acid (RNA) having at least 85% identity with a sequence chosen from SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6 and SEQ ID NO: 7, preferably chosen from SEQ ID NO: 1 and SEQ ID NO: 2. The present invention also relates to a composition or a kit comprising at least one of these aptamers, and also to the uses thereof in vitro. The present invention also relates to a method for diagnosing synucleinopathies, as well as to a method for stratification, monitoring, prognosis and evaluation of the efficacy of a synucleinopathy treatment, comprising the use of at least one aptamer and/or a composition and/or a kit mentioned above.
    Type: Application
    Filed: May 25, 2022
    Publication date: July 18, 2024
    Inventors: Alix BOUVIER-MULLER, Frederic DUCONGE, Luc BOUSSET, Ronald MELKI
  • LAR protein-specific ligand
    Patent number: 9365854
    Abstract: The present invention relates to an aptamer comprising a nucleic acid comprising, or consisting of: —the sequence ACUGU CCCAG UAUGA CGCGA CUGCU UAGGU GGGAU GUUUC CCAUG CCUCG (SEQ ID NO: 1), or —a sequence comprising, or consisting of, at least 25 consecutive nucleotides in a sequence having at least 80% identity with SEQ ID NO: 1, with the proviso that a nucleic acid consisting of this sequence binds to the LAR protein.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: June 14, 2016
    Assignee: Commissariat a l'Energie Atomique et aux Energies alternatives
    Inventors: Frederic Duconge, Agnes Cibiel
  • LAR Protein-Specific Ligand
    Publication number: 20130266516
    Abstract: The present invention relates to an aptamer comprising a nucleic acid comprising, or consisting of: the sequence ACUGU CCCAG UAUGA CGCGA CUGCU UAGGU GGGAU GUUUC CCAUG CCUCG (SEQ ID NO: 1), or a sequence comprising, or consisting of, at least 25 consecutive nucleotides in a sequence having at least 80% identity with SEQ ID NO: 1, with the proviso that a nucleic acid consisting of this sequence binds to the LAR protein.
    Type: Application
    Filed: December 15, 2011
    Publication date: October 10, 2013
    Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES
    Inventors: Frederic Duconge, Agnes Cibiel
  • NUCLEIC ACIDS SPECIFICALLY BINDING WITH HUMAN FACTOR VII/VIIA AND USES THEREOF
    Publication number: 20120041056
    Abstract: A nucleic acid includes at least 15 nucleotides with a length specifically binding with the human factor VII/VIIa.
    Type: Application
    Filed: February 19, 2010
    Publication date: February 16, 2012
    Applicant: LFB BIOTECHNOLOGIES
    Inventors: Gerald Perret, Frederic Duconge
  • Aptamers Selected From Live Tumor Cells and the Use Thereof
    Publication number: 20080227735
    Abstract: The invention relates to aptamers selected from live tumor cells and to the use thereof for diagnosis and treatment of certain cancers and other pathologies.
    Type: Application
    Filed: March 17, 2005
    Publication date: September 18, 2008
    Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE
    Inventors: Bertrand Tavitian, Frederic Duconge, Domenico Libri, Vittorio De Franciscis, Laura Cerchia