Patents by Inventor Frederic Ginot

Frederic Ginot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240401115
    Abstract: The method for desalting and concentrating a nucleic acid sample more conductive than an analysis buffer comprises at least one iteration of an alternation of: a step of the laminar flow of the sample through a capillary in a first direction of flow, the capillary being equipped with a local restriction in its cross-section and comprising the analysis buffer, during which the sample is subjected to a first difference in electric potential whose action on the nucleic acid molecules is opposite to the direction of flow and causes the nucleic acid molecules to be retained in the capillary; a step of the laminar flow of the sample, in a second direction of flow opposite to the first direction of flow.
    Type: Application
    Filed: October 13, 2022
    Publication date: December 5, 2024
    Inventors: Frederic GINOT, Audrey BOUTONNET
  • Publication number: 20200249135
    Abstract: The invention relates to a system (700) for treating molecules or particles of interest carried by a viscoelastic liquid, which comprises: a means (715) for establishing a laminar flow, during at least one portion, referred to as “concentration phase”, of the operating time of the system, of the viscoelastic liquid in a concentration, stacking and/or purification device (705), said device comprising a concentration area having, in the direction of said flow, an intake cross-section surface that is larger than the cross-section surface of each outlet channel, and a means (725) for applying an electric field between the intake and the outlet of the concentration area during the concentration phase, the action of the electric field on the molecules or particles of interest being, in the concentration area, opposite to the direction of said flow and causing the molecules or particles of interest to be retained at least in the concentration area; which also comprises a modulation means (730) configured to cont
    Type: Application
    Filed: April 23, 2020
    Publication date: August 6, 2020
    Inventors: Frederic GINOT, Comtet-Louis ANDRIAMANAMPISOA, Vincent PICOT, Audrey BOUTONNET, Aurelien BANCAUD
  • Publication number: 20180202907
    Abstract: The invention relates to a system (700) for treating molecules or particles of interest carried by a viscoelastic liquid, which comprises: a means (715) for establishing a laminar flow, during at least one portion, referred to as “concentration phase”, of the operating time of the system, of the viscoelastic liquid in a concentration, stacking and/or purification device (705), said device comprising a concentration area having, in the direction of said flow, an intake cross-section surface that is larger than the cross-section surface of each outlet channel, and a means (725) for applying an electric field between the intake and the outlet of the concentration area during the concentration phase, the action of the electric field on the molecules or particles of interest being, in the concentration area, opposite to the direction of said flow and causing the molecules or particles of interest to be retained at least in the concentration area; which also comprises a modulation means (730) configured to cont
    Type: Application
    Filed: July 11, 2016
    Publication date: July 19, 2018
    Inventors: Frederic GINOT, Comtet-Louis ANDRIAMANAMPISOA, Vincent PICOT, Audrey BOUTONNET, Aurelien BANCAUD
  • Patent number: 8673153
    Abstract: A method for dividing an analyte present in a solution and that is fixed on magnetic particles, and devices to be used in the method and systems for implementing the method. The method includes sedimentation of the magnetic particles together with separation into a plurality of residues. One implementation: forms at least a residue of magnetic particles in a first receptacle; and displaces the at least the residues towards a plurality of second receptacles, preferably by relative translation of a magnetic system. The second receptacle is connected to the first receptacle through a fluid channel.
    Type: Grant
    Filed: December 13, 2004
    Date of Patent: March 18, 2014
    Assignees: Commissariat a l'Energie Atomique, Biomerieux SA
    Inventors: Raymond Campagnolo, Christian Jeandey, Frederic Ginot, Patrick Pouteau
  • Patent number: 8216827
    Abstract: The disclosure relates to a biological analysis device including: means for circulating a fluid to be analyzed, comprising a fluidic chamber, optical detection means based on a semiconductor, including a detection front face, a rear face and pads of electrical contacts located on this rear face.
    Type: Grant
    Filed: January 31, 2006
    Date of Patent: July 10, 2012
    Assignees: Commissariat a l'Energie Atomique, Biomerieux SA
    Inventors: Patrick Pouteau, Raymond Campagnolo, Frederic Mallard, Frederic Ginot
  • Patent number: 7713484
    Abstract: The invention concerns a device for isolating, on a reactive surface, an analyte from a liquid sample containing the analyte.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: May 11, 2010
    Assignees: Biomerieux, Commissariat a l'Energie Atomique
    Inventors: Frederic Ginot, Jean-Luc Achard, Laurent Drazek, Pascale Pham
  • Patent number: 7553621
    Abstract: The invention relates to a method of reading, detecting or quantifying at least one biological reaction, on a support, between either a recognition molecule and a labeled target molecule or between a target molecule and a labeled detection molecule. The inventive method comprises treating the support under physicochemical conditions that allow the following: either the separation of the recognition molecule and the labeled target molecule or the separation of the target molecule and the labeled detection molecule. The inventive method further comprises producing images before and after the physicochemical treatment that can be used to determine the specific and non-specific bindings between the different molecules. The invention also relates to hybrids and complexes used in the inventive method and to a biochip containing the same which is used to carry out the inventive method. The invention is particularly suitable for use in the field of diagnosis.
    Type: Grant
    Filed: September 9, 2002
    Date of Patent: June 30, 2009
    Assignees: BioMerieux, Commissariat A l'Energie Atomique
    Inventors: Frederic Ginot, Dominique Masse, Arnelle Novelli-Rousseau, Severine Moutin
  • Publication number: 20090104080
    Abstract: The invention concerns a device for isolating, on a reactive surface, an analyte from a liquid sample containing the analyte.
    Type: Application
    Filed: October 1, 2008
    Publication date: April 23, 2009
    Applicants: BIOMERIEUX, COMMISSARIAT A L'ENERGIE ATOMIQUE
    Inventors: Frederic Ginot, Jean-Luc Achard, Laurent Drazek, Pascale Pham
  • Publication number: 20090013768
    Abstract: The disclosure relates to a biological analysis device including: means for circulating a fluid to be analyzed, comprising a fluidic chamber, optical detection means based on a semiconductor, including a detection front face, a rear face and pads of electrical contacts located on this rear face.
    Type: Application
    Filed: January 31, 2006
    Publication date: January 15, 2009
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE, BIOMERIEUX SA
    Inventors: Patrick Pouteau, Raymond Campagnolo, Frederic Mallard, Frederic Ginot
  • Patent number: 7449341
    Abstract: The invention concerns a method for isolating an analyte from an initial sample containing same, on a reactive surface in contact with all or part of the initial sample, characterized in that it comprises the following steps which consist in: 1) forming and/or maintaining a reaction volume entity, comprising an internal liquid medium, corresponding to all or part of the initial sample, the entity including an interface with an external medium, having with the latter a surface tension; 2) applying a temperature difference between at least two thermal points located: a) proximate to and/or b) on the surface and/or c) within said entity, said thermal points being respectively different, in terms of temperature and positioning; 3) fixing the analyte on the reactive surface, positioned on the path of forces convection generated by the temperature difference.
    Type: Grant
    Filed: September 12, 2002
    Date of Patent: November 11, 2008
    Assignees: Biomerieux, Commissariat a l'Energie Atomique
    Inventors: Frederic Ginot, Jean-Luc Achard, Laurent Drazek, Pascale Pham
  • Publication number: 20080233632
    Abstract: The present invention relates to a process for labeling and purification of nucleic acids of interest present in a biological sample to be treated, comprising: taking a single reaction vessel, introducing into the reaction vessel: the biological sample, at least one labeling reagent for nucleic acids, at least one solid support enabling the adsorption of said nucleic acids, any ingredient necessary for the labeling of the nucleic acids and/or for the immobilization of said nucleic acids on the support, incubating the contents of the reaction vessel, and isolating the nucleic acids thus labeled. The invention finds a preferred application in the diagnostics field.
    Type: Application
    Filed: July 21, 2005
    Publication date: September 25, 2008
    Applicant: BIOMERIEUX
    Inventors: Ali Laayoun, Lionel Menou, Frederic Ginot
  • Publication number: 20070218452
    Abstract: The present invention relates especially to a process for the localized distribution of drops of a liquid of interest on an active surface. The process comprises the following steps an introduction of liquid of interest into a box containing the said active surface, and an extraction of liquid of interest from the said box, the said active surface and also the other surfaces inside the box being substantially non-wetting with respect to the liquid of interest, with the exception of several uptake areas localized on the said active surface, which are each suitable for taking up a drop of liquid of interest. The uptake areas may surround working areas. The present invention also relates to processes for the electrochemical and optical detection of at least one analyte in a liquid of interest, and to an electropolymerization process.
    Type: Application
    Filed: October 21, 2004
    Publication date: September 20, 2007
    Applicant: Commissariat A L'Energie Atomique
    Inventors: Cyril Delattre, Gilles Marchand, Patrick Pouteau, Frederic Ginot
  • Publication number: 20070199901
    Abstract: A method for dividing an analyte present in a solution and that is fixed on magnetic particles, and devices to be used in the method and systems for implementing the method. The method includes sedimentation of the magnetic particles together with separation into a plurality of residues. One implementation: forms at least a residue of magnetic particles in a first receptacle; and displaces the at least the residues towards a plurality of second receptacles, preferably by relative translation of a magnetic system. The second receptacle is connected to the first receptacle through a fluid channel.
    Type: Application
    Filed: December 13, 2004
    Publication date: August 30, 2007
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE, BIOMERIEUX SA
    Inventors: Raymond Campagnolo, Christian Jeandey, Frederic Ginot, Patrick Pouteau
  • Publication number: 20070105210
    Abstract: The present invention relates to a work device (1) comprising work zones. It can be used to obtain a matrix of drops on a surface, using a liquid of interest (E). It comprises a work box (Bo) provided with means (o, s) for introducing and extracting the liquid respectively into and from the box; a substrate (S) comprising an active surface that is substantially non-wetting for said liquid of interest contained in said box; distinct work zones (Zt) formed on said active surface and each surrounded by a border (b) formed on said active surface, the borders not touching one another and having no common edge and having a geometry such that when the liquid of interest is extracted from the box, a drop (g) of the liquid of interest remains imprisoned by each border and in contact with the work zone that it surrounds.
    Type: Application
    Filed: October 21, 2004
    Publication date: May 10, 2007
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE, BIOMERIEUX SA
    Inventors: Cyril Delattre, Gilles Marchand, Patrick Pouteau, Frederic Ginot
  • Publication number: 20060023216
    Abstract: The invention concerns a device (1) for testing at least one sample by optical detection of luminescence, comprising a site for receiving (3) the sample, said site being arranged in such a way that the sample can receive a luminescence excitation and emit a luminescence light in an optical guiding plane (2) of the device, the device further comprising collection means (7) optically connected to the optical guiding plane (2) to receive the luminescence light. The device further comprises means that make it possible to send back towards the collection means (4) a part of the luminescence light emitted in the optical guiding plane and not directly collected by the collection means.
    Type: Application
    Filed: October 23, 2003
    Publication date: February 2, 2006
    Inventors: Pierre Labeye, Patrick Pouteau, Francois Perraut, Frederic Ginot
  • Publication number: 20050196328
    Abstract: The invention relates to hydraulic device produced from one or several components, for example from a support comprising: an operative cavity, at least two ducts, for example an inlet and outlet for a liquid of interest which communicate with said operative cavity, at least two valve bodies with no moving pieces for control of said cavity. The above is characterised in that said device further comprises two trapping chambers for a gas, for example, air, in communication only and respectively with two ducts, by means of two connecting channels respectively, both pertaining to thermal exchange with a heat source.
    Type: Application
    Filed: June 24, 2003
    Publication date: September 8, 2005
    Applicants: Bio Merieux, Commissariat A L'Energie Atomique
    Inventors: Yves Fouillet, Patrick Pouteau, Nicolas Sarrut, Frederic Ginot, Dominique Masse
  • Publication number: 20050142549
    Abstract: The invention relates to a method of reading, detecting or quantifying at least one biological reaction, on a support, between either a recognition molecule and a labeled target molecule or between a target molecule and a labeled detection molecule. The inventive method comprises treating the support under physicochemical conditions that allow the following: either the separation of the recognition molecule and the labeled target molecule or the separation of the target molecule and the labeled detection molecule. The inventive method further comprises producing images before and after the physicochemical treatment that can be used to determine the specific and non-specific bindings between the different molecules. The invention also relates to hybrids and complexes used in the inventive method and to a biochip containing the same which is used to carry out the inventive method. The invention is particularly suitable for use in the field of diagnosis.
    Type: Application
    Filed: September 9, 2002
    Publication date: June 30, 2005
    Inventors: Frederic Ginot, Dominique Masse, Arnelle Novelli-Rousseau, Severine Moutin
  • Publication number: 20050064603
    Abstract: The invention concerns a method for isolating an analyte from an initial sample containing same, on a reactive surface in contact with all or part of the initial sample, characterized in that it comprises the following steps which consist in: 1) forming and/or maintaining a reaction volume entity, comprising an internal liquid medium, corresponding to all or part of the initial sample, the entity including an interface with an external medium, having with the latter a surface tension; 2) applying a temperature difference between at least two thermal points located: a) proximate to and/or b) on the surface and/or c) within said entity, said thermal points being respectively different, in terms of temperature and positioning; 3) fixing the analyte on the reactive surface, positioned on the path of forces convection generated by the temperature difference.
    Type: Application
    Filed: September 12, 2002
    Publication date: March 24, 2005
    Inventors: Frederic Ginot, Jean-Luc Achard, Laurent Drazek, Pascale Pham
  • Publication number: 20040023273
    Abstract: The present invention relates to a method of transporting an analyte present in a sample, to a method of concentrating an analyte present in a sample, and to a device for implementing these methods.
    Type: Application
    Filed: May 8, 2003
    Publication date: February 5, 2004
    Inventors: Pierre Puget, Patrick Pouteau, Frederic Ginot, Patrice Caillat
  • Patent number: 6218116
    Abstract: A method for determining the presence, in a liquid medium, of a plurality of different nucleic ligands in the free state comprises: (a) providing a support for plural complexing on which are distributed a plurality of immobilizing sites in which are immobilized a plurality of different nucleic anti-ligands; and (b) contacting the liquid medium with the support, whereby the nucleic ligands are paired with the nucleic anti-ligands. The stability of each ligand/anti-ligand complex is dependent upon at least one exogenous parameter, namely temperature, conditioning the support; the immobilizing sites on the support are differentiated, depending on the exogenous parameter, having respectively different values in the sites; and the anti-ligands are distributed among the different immobilizing sites, depending on the optimum values of the exogenous parameter, determining the stability of the different nucleic ligand/anti-ligand complexes respectively.
    Type: Grant
    Filed: June 26, 1998
    Date of Patent: April 17, 2001
    Assignee: Bio Merieux
    Inventor: Frederic Ginot