Patents by Inventor Frederic Ginot
Frederic Ginot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240401115Abstract: The method for desalting and concentrating a nucleic acid sample more conductive than an analysis buffer comprises at least one iteration of an alternation of: a step of the laminar flow of the sample through a capillary in a first direction of flow, the capillary being equipped with a local restriction in its cross-section and comprising the analysis buffer, during which the sample is subjected to a first difference in electric potential whose action on the nucleic acid molecules is opposite to the direction of flow and causes the nucleic acid molecules to be retained in the capillary; a step of the laminar flow of the sample, in a second direction of flow opposite to the first direction of flow.Type: ApplicationFiled: October 13, 2022Publication date: December 5, 2024Inventors: Frederic GINOT, Audrey BOUTONNET
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Publication number: 20200249135Abstract: The invention relates to a system (700) for treating molecules or particles of interest carried by a viscoelastic liquid, which comprises: a means (715) for establishing a laminar flow, during at least one portion, referred to as “concentration phase”, of the operating time of the system, of the viscoelastic liquid in a concentration, stacking and/or purification device (705), said device comprising a concentration area having, in the direction of said flow, an intake cross-section surface that is larger than the cross-section surface of each outlet channel, and a means (725) for applying an electric field between the intake and the outlet of the concentration area during the concentration phase, the action of the electric field on the molecules or particles of interest being, in the concentration area, opposite to the direction of said flow and causing the molecules or particles of interest to be retained at least in the concentration area; which also comprises a modulation means (730) configured to contType: ApplicationFiled: April 23, 2020Publication date: August 6, 2020Inventors: Frederic GINOT, Comtet-Louis ANDRIAMANAMPISOA, Vincent PICOT, Audrey BOUTONNET, Aurelien BANCAUD
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Publication number: 20180202907Abstract: The invention relates to a system (700) for treating molecules or particles of interest carried by a viscoelastic liquid, which comprises: a means (715) for establishing a laminar flow, during at least one portion, referred to as “concentration phase”, of the operating time of the system, of the viscoelastic liquid in a concentration, stacking and/or purification device (705), said device comprising a concentration area having, in the direction of said flow, an intake cross-section surface that is larger than the cross-section surface of each outlet channel, and a means (725) for applying an electric field between the intake and the outlet of the concentration area during the concentration phase, the action of the electric field on the molecules or particles of interest being, in the concentration area, opposite to the direction of said flow and causing the molecules or particles of interest to be retained at least in the concentration area; which also comprises a modulation means (730) configured to contType: ApplicationFiled: July 11, 2016Publication date: July 19, 2018Inventors: Frederic GINOT, Comtet-Louis ANDRIAMANAMPISOA, Vincent PICOT, Audrey BOUTONNET, Aurelien BANCAUD
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Patent number: 8673153Abstract: A method for dividing an analyte present in a solution and that is fixed on magnetic particles, and devices to be used in the method and systems for implementing the method. The method includes sedimentation of the magnetic particles together with separation into a plurality of residues. One implementation: forms at least a residue of magnetic particles in a first receptacle; and displaces the at least the residues towards a plurality of second receptacles, preferably by relative translation of a magnetic system. The second receptacle is connected to the first receptacle through a fluid channel.Type: GrantFiled: December 13, 2004Date of Patent: March 18, 2014Assignees: Commissariat a l'Energie Atomique, Biomerieux SAInventors: Raymond Campagnolo, Christian Jeandey, Frederic Ginot, Patrick Pouteau
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Patent number: 8216827Abstract: The disclosure relates to a biological analysis device including: means for circulating a fluid to be analyzed, comprising a fluidic chamber, optical detection means based on a semiconductor, including a detection front face, a rear face and pads of electrical contacts located on this rear face.Type: GrantFiled: January 31, 2006Date of Patent: July 10, 2012Assignees: Commissariat a l'Energie Atomique, Biomerieux SAInventors: Patrick Pouteau, Raymond Campagnolo, Frederic Mallard, Frederic Ginot
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Patent number: 7713484Abstract: The invention concerns a device for isolating, on a reactive surface, an analyte from a liquid sample containing the analyte.Type: GrantFiled: October 1, 2008Date of Patent: May 11, 2010Assignees: Biomerieux, Commissariat a l'Energie AtomiqueInventors: Frederic Ginot, Jean-Luc Achard, Laurent Drazek, Pascale Pham
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Patent number: 7553621Abstract: The invention relates to a method of reading, detecting or quantifying at least one biological reaction, on a support, between either a recognition molecule and a labeled target molecule or between a target molecule and a labeled detection molecule. The inventive method comprises treating the support under physicochemical conditions that allow the following: either the separation of the recognition molecule and the labeled target molecule or the separation of the target molecule and the labeled detection molecule. The inventive method further comprises producing images before and after the physicochemical treatment that can be used to determine the specific and non-specific bindings between the different molecules. The invention also relates to hybrids and complexes used in the inventive method and to a biochip containing the same which is used to carry out the inventive method. The invention is particularly suitable for use in the field of diagnosis.Type: GrantFiled: September 9, 2002Date of Patent: June 30, 2009Assignees: BioMerieux, Commissariat A l'Energie AtomiqueInventors: Frederic Ginot, Dominique Masse, Arnelle Novelli-Rousseau, Severine Moutin
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Publication number: 20090104080Abstract: The invention concerns a device for isolating, on a reactive surface, an analyte from a liquid sample containing the analyte.Type: ApplicationFiled: October 1, 2008Publication date: April 23, 2009Applicants: BIOMERIEUX, COMMISSARIAT A L'ENERGIE ATOMIQUEInventors: Frederic Ginot, Jean-Luc Achard, Laurent Drazek, Pascale Pham
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Publication number: 20090013768Abstract: The disclosure relates to a biological analysis device including: means for circulating a fluid to be analyzed, comprising a fluidic chamber, optical detection means based on a semiconductor, including a detection front face, a rear face and pads of electrical contacts located on this rear face.Type: ApplicationFiled: January 31, 2006Publication date: January 15, 2009Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE, BIOMERIEUX SAInventors: Patrick Pouteau, Raymond Campagnolo, Frederic Mallard, Frederic Ginot
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Patent number: 7449341Abstract: The invention concerns a method for isolating an analyte from an initial sample containing same, on a reactive surface in contact with all or part of the initial sample, characterized in that it comprises the following steps which consist in: 1) forming and/or maintaining a reaction volume entity, comprising an internal liquid medium, corresponding to all or part of the initial sample, the entity including an interface with an external medium, having with the latter a surface tension; 2) applying a temperature difference between at least two thermal points located: a) proximate to and/or b) on the surface and/or c) within said entity, said thermal points being respectively different, in terms of temperature and positioning; 3) fixing the analyte on the reactive surface, positioned on the path of forces convection generated by the temperature difference.Type: GrantFiled: September 12, 2002Date of Patent: November 11, 2008Assignees: Biomerieux, Commissariat a l'Energie AtomiqueInventors: Frederic Ginot, Jean-Luc Achard, Laurent Drazek, Pascale Pham
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Publication number: 20080233632Abstract: The present invention relates to a process for labeling and purification of nucleic acids of interest present in a biological sample to be treated, comprising: taking a single reaction vessel, introducing into the reaction vessel: the biological sample, at least one labeling reagent for nucleic acids, at least one solid support enabling the adsorption of said nucleic acids, any ingredient necessary for the labeling of the nucleic acids and/or for the immobilization of said nucleic acids on the support, incubating the contents of the reaction vessel, and isolating the nucleic acids thus labeled. The invention finds a preferred application in the diagnostics field.Type: ApplicationFiled: July 21, 2005Publication date: September 25, 2008Applicant: BIOMERIEUXInventors: Ali Laayoun, Lionel Menou, Frederic Ginot
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Publication number: 20070218452Abstract: The present invention relates especially to a process for the localized distribution of drops of a liquid of interest on an active surface. The process comprises the following steps an introduction of liquid of interest into a box containing the said active surface, and an extraction of liquid of interest from the said box, the said active surface and also the other surfaces inside the box being substantially non-wetting with respect to the liquid of interest, with the exception of several uptake areas localized on the said active surface, which are each suitable for taking up a drop of liquid of interest. The uptake areas may surround working areas. The present invention also relates to processes for the electrochemical and optical detection of at least one analyte in a liquid of interest, and to an electropolymerization process.Type: ApplicationFiled: October 21, 2004Publication date: September 20, 2007Applicant: Commissariat A L'Energie AtomiqueInventors: Cyril Delattre, Gilles Marchand, Patrick Pouteau, Frederic Ginot
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Publication number: 20070199901Abstract: A method for dividing an analyte present in a solution and that is fixed on magnetic particles, and devices to be used in the method and systems for implementing the method. The method includes sedimentation of the magnetic particles together with separation into a plurality of residues. One implementation: forms at least a residue of magnetic particles in a first receptacle; and displaces the at least the residues towards a plurality of second receptacles, preferably by relative translation of a magnetic system. The second receptacle is connected to the first receptacle through a fluid channel.Type: ApplicationFiled: December 13, 2004Publication date: August 30, 2007Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE, BIOMERIEUX SAInventors: Raymond Campagnolo, Christian Jeandey, Frederic Ginot, Patrick Pouteau
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Publication number: 20070105210Abstract: The present invention relates to a work device (1) comprising work zones. It can be used to obtain a matrix of drops on a surface, using a liquid of interest (E). It comprises a work box (Bo) provided with means (o, s) for introducing and extracting the liquid respectively into and from the box; a substrate (S) comprising an active surface that is substantially non-wetting for said liquid of interest contained in said box; distinct work zones (Zt) formed on said active surface and each surrounded by a border (b) formed on said active surface, the borders not touching one another and having no common edge and having a geometry such that when the liquid of interest is extracted from the box, a drop (g) of the liquid of interest remains imprisoned by each border and in contact with the work zone that it surrounds.Type: ApplicationFiled: October 21, 2004Publication date: May 10, 2007Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE, BIOMERIEUX SAInventors: Cyril Delattre, Gilles Marchand, Patrick Pouteau, Frederic Ginot
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Publication number: 20060023216Abstract: The invention concerns a device (1) for testing at least one sample by optical detection of luminescence, comprising a site for receiving (3) the sample, said site being arranged in such a way that the sample can receive a luminescence excitation and emit a luminescence light in an optical guiding plane (2) of the device, the device further comprising collection means (7) optically connected to the optical guiding plane (2) to receive the luminescence light. The device further comprises means that make it possible to send back towards the collection means (4) a part of the luminescence light emitted in the optical guiding plane and not directly collected by the collection means.Type: ApplicationFiled: October 23, 2003Publication date: February 2, 2006Inventors: Pierre Labeye, Patrick Pouteau, Francois Perraut, Frederic Ginot
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Publication number: 20050196328Abstract: The invention relates to hydraulic device produced from one or several components, for example from a support comprising: an operative cavity, at least two ducts, for example an inlet and outlet for a liquid of interest which communicate with said operative cavity, at least two valve bodies with no moving pieces for control of said cavity. The above is characterised in that said device further comprises two trapping chambers for a gas, for example, air, in communication only and respectively with two ducts, by means of two connecting channels respectively, both pertaining to thermal exchange with a heat source.Type: ApplicationFiled: June 24, 2003Publication date: September 8, 2005Applicants: Bio Merieux, Commissariat A L'Energie AtomiqueInventors: Yves Fouillet, Patrick Pouteau, Nicolas Sarrut, Frederic Ginot, Dominique Masse
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Publication number: 20050142549Abstract: The invention relates to a method of reading, detecting or quantifying at least one biological reaction, on a support, between either a recognition molecule and a labeled target molecule or between a target molecule and a labeled detection molecule. The inventive method comprises treating the support under physicochemical conditions that allow the following: either the separation of the recognition molecule and the labeled target molecule or the separation of the target molecule and the labeled detection molecule. The inventive method further comprises producing images before and after the physicochemical treatment that can be used to determine the specific and non-specific bindings between the different molecules. The invention also relates to hybrids and complexes used in the inventive method and to a biochip containing the same which is used to carry out the inventive method. The invention is particularly suitable for use in the field of diagnosis.Type: ApplicationFiled: September 9, 2002Publication date: June 30, 2005Inventors: Frederic Ginot, Dominique Masse, Arnelle Novelli-Rousseau, Severine Moutin
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Publication number: 20050064603Abstract: The invention concerns a method for isolating an analyte from an initial sample containing same, on a reactive surface in contact with all or part of the initial sample, characterized in that it comprises the following steps which consist in: 1) forming and/or maintaining a reaction volume entity, comprising an internal liquid medium, corresponding to all or part of the initial sample, the entity including an interface with an external medium, having with the latter a surface tension; 2) applying a temperature difference between at least two thermal points located: a) proximate to and/or b) on the surface and/or c) within said entity, said thermal points being respectively different, in terms of temperature and positioning; 3) fixing the analyte on the reactive surface, positioned on the path of forces convection generated by the temperature difference.Type: ApplicationFiled: September 12, 2002Publication date: March 24, 2005Inventors: Frederic Ginot, Jean-Luc Achard, Laurent Drazek, Pascale Pham
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Publication number: 20040023273Abstract: The present invention relates to a method of transporting an analyte present in a sample, to a method of concentrating an analyte present in a sample, and to a device for implementing these methods.Type: ApplicationFiled: May 8, 2003Publication date: February 5, 2004Inventors: Pierre Puget, Patrick Pouteau, Frederic Ginot, Patrice Caillat
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Patent number: 6218116Abstract: A method for determining the presence, in a liquid medium, of a plurality of different nucleic ligands in the free state comprises: (a) providing a support for plural complexing on which are distributed a plurality of immobilizing sites in which are immobilized a plurality of different nucleic anti-ligands; and (b) contacting the liquid medium with the support, whereby the nucleic ligands are paired with the nucleic anti-ligands. The stability of each ligand/anti-ligand complex is dependent upon at least one exogenous parameter, namely temperature, conditioning the support; the immobilizing sites on the support are differentiated, depending on the exogenous parameter, having respectively different values in the sites; and the anti-ligands are distributed among the different immobilizing sites, depending on the optimum values of the exogenous parameter, determining the stability of the different nucleic ligand/anti-ligand complexes respectively.Type: GrantFiled: June 26, 1998Date of Patent: April 17, 2001Assignee: Bio MerieuxInventor: Frederic Ginot