Patents by Inventor Frederic Huche

Frederic Huche has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Additive for the crystallization of proteins, use and process
    Patent number: 9180386
    Abstract: The present invention relates to the use and to a process involving at least one calix[n]arene derivative substituted by at least one acid functional group on the upper face and at least one aliphatic chain of variable length on the other face, as an additive for crystallization of a polar and/or positively charged molecule. The use and the process of the present invention have the advantage of enabling, facilitating and/or accelerating the crystallization of polar and/or positively charged molecules, especially of membrane proteins that are in solution or soluble, which had previously proved to be very difficult.
    Type: Grant
    Filed: April 2, 2010
    Date of Patent: November 10, 2015
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS—, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: Pierre G. Falson, Anthony W. Coleman, Rachel Rima Matar Merheb, Antoine Leydier, Frederic Huche
  • Method for selectively extracting membrane proteins using calixarenes
    Patent number: 8481691
    Abstract: The present invention relates to a method for selectively extracting membrane proteins using at least one calixarene of formula (I). The use of calixarenes in the method according to the invention enables the selective solubilization of the membrane proteins while preserving the three-dimensional structure that is essential to the enzymatic activity thereof.
    Type: Grant
    Filed: May 28, 2009
    Date of Patent: July 9, 2013
    Assignees: Centre National de la Recherche Scientifique—CNRS, Universite Claude Bernard de Lyon 1
    Inventors: Anthony W. Coleman, Cyrille Mbemba, Pierre Falson, Rima Matar, Frederic Huche
  • ADDITIVE FOR THE CRYSTALLIZATION OF PROTEINS, USE AND PROCESS
    Publication number: 20120123088
    Abstract: The present invention relates to the use and to a process involving at least one calix[n]arene derivative substituted by at least one acid functional group on the upper face and at least one aliphatic chain of variable length on the other face, as an additive for crystallization of a polar and/or positively charged molecule. The use and the process of the present invention have the advantage of enabling, facilitating and/or accelerating the crystallization of polar and/or positively charged molecules, especially of membrane proteins that are in solution or soluble, which had previously proved to be very difficult.
    Type: Application
    Filed: April 2, 2010
    Publication date: May 17, 2012
    Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS
    Inventors: Pierre G. Falson, Anthony W. Coleman, Rachel Rima Matar Merheb, Antoine Leydier, Frederic Huche