Patents by Inventor Frederic J. Kaye

Frederic J. Kaye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for inhibiting translation of a Mect1-MAML2 chimeric gene
    Patent number: 8124753
    Abstract: Composition for the inhibition of the translation of a Mect1-MAML2 chimeric gene consisting essentially of: (a) a fragment of the nucleic acid encoding the chimeric gene, and (b) a nucleic acid complementary to the fragment, and a method of inhibiting the translation of a Mect1-MAML2 chimeric gene comprising contacting a cell expressing the chimeric gene with the composition, whereupon the translation of the chimeric gene is inhibited.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: February 28, 2012
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Frederic J. Kaye, Takefumi Komiya
  • COMPOSITIONS AND METHODS FOR INHIBITING TRANSLATION OF A MECT1-MAML2 CHIMERIC GENE
    Publication number: 20090326054
    Abstract: Composition for the inhibition of the translation of a Mect1-MAML2 chimeric gene consisting essentially of: (a) a fragment of the nucleic acid encoding the chimeric gene, and (b) a nucleic acid complementary to the fragment, and a method of inhibiting the translation of a Mect1-MAML2 chimeric gene comprising contacting a cell expressing the chimeric gene with the composition, whereupon the translation of the chimeric gene is inhibited.
    Type: Application
    Filed: June 29, 2009
    Publication date: December 31, 2009
    Inventors: Frederic J. Kaye, Takefumi Komiya
  • Compositions and methods for inhibiting translation of a Mect1-MAML2 chimeric gene
    Patent number: 7553822
    Abstract: Composition for the inhibition of the translation of a Mect1-MAML2 chimeric gene consisting essentially of: (a) a fragment of the nucleic acid encoding the chimeric gene, and (b) a nucleic acid complementary to the fragment, and a method of inhibiting the translation of a Mect1-MAML2 chimeric gene comprising contacting a cell expressing the chimeric gene with the composition, whereupon the translation of the chimeric gene is inhibited.
    Type: Grant
    Filed: October 30, 2003
    Date of Patent: June 30, 2009
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Frederic J. Kaye, Takefumi Komiya
  • Detection of MECT1-MAML2 fusion products
    Patent number: 7214488
    Abstract: The present invention provides methods and compositions for the diagnosis and treatment of cancer, including cancers involving the NOTCH pathway. In particular, the present invention provides methods and compositions for the diagnosis of mucoepidermoid carcinoma, the most common malignant salivary gland tumor. The present invention further provides methods and compositions for the diagnosis of other tumors associated with the t(11;19)(q14–21;12–13) translocation.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: May 8, 2007
    Assignee: United States of America, Represented by the Secretary, Department of Health and Human Services
    Inventors: Frederic J. Kaye, Giovanni Tonon
  • Diagnosis and treatment of cancer involving the notch pathway
    Publication number: 20040180349
    Abstract: The present invention provides methods and compositions for the diagnosis and treatment of cancer, including cancers involving the NOTCH pathway. In particular, the present invention provides methods and compositions for the diagnosis of mucoepidermoid carcinoma, the most common malignant salivary gland tumor. The present invention further provides methods and compositions for the diagnosis of other tumors associated with the t(11;19)(q14-21;12-13) translocation.
    Type: Application
    Filed: March 29, 2004
    Publication date: September 16, 2004
    Inventors: Frederic J. Kaye, Giovanni Tonon
  • Isolation and characterization of a novel chaperone protein
    Patent number: 5646249
    Abstract: This invention relates to the identification and molecular characterization of the human and rat STCH chaperone protein including the corresponding gene sequence, gene fragments and protein fragments. The invention also relates antibodies to STCH and to assays to detect the presence of STCH genes, transcripts and protein in a sample.
    Type: Grant
    Filed: February 28, 1994
    Date of Patent: July 8, 1997
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Frederic J. Kaye, Gregory A. Otterson