Abstract: The present invention provides compounds of the formula: wherein A, Z, G, R1, R2, and R4 are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and pharmaceutically acceptable salts thereof for treating patients for cancer.

Abstract: Devices and techniques are generally described for image-guided three dimensional (3D) modeling. In various examples, a first two-dimensional (2D) image representing an object may be received. A first three-dimensional (3D) model corresponding to the first 2D image may be determined from among a plurality of 3D models. A first selection of a first portion of the first 2D image may be received. A second selection of a second portion of the first 3D model corresponding to the portion of the first 2D image may be received. At least one transformation of the first 3D model may be determined based at least in part on differences between a geometric feature of the first portion of the first 2D image and a geometric feature of the second portion of the first 3D model. A modified 3D model may be generated by applying the at least one transformation to the first 3D model.

Abstract: The invention relates to a thermal-treatment vessel (17) for pathogenic liquids intended for being filled to a predetermined level leaving a compression dome, characterised by comprising at least one pressurised-steam injector (31) positioned such as to be submerged in the liquid contaminated by pathogenic agents when the thermal-treatment vessel (17) is filled to the predetermined level with the liquid contaminated with pathogenic agents and directed toward the inside of the thermal-treatment vessel (17) with at least one tangential component so as to create a cyclonic movement of the liquid contaminated with pathogenic agents to be decontaminated.

Abstract: The invention relates to a thermal-treatment vessel (17) for pathogenic liquids intended for being filled to a predetermined level leaving a compression dome, characterised by comprising at least one pressurised-steam injector (31) positioned such as to be submerged in the liquid contaminated by pathogenic agents when the thermal-treatment vessel (17) is filled to the predetermined level with the liquid contaminated with pathogenic agents and directed toward the inside of the thermal-treatment vessel (17) with at least one tangential component so as to create a cyclonic movement of the liquid contaminated with pathogenic agents to be decontaminated.

Abstract: The present invention relates to a melanin concentrating hormone antagonist compound of formula (I); wherein Ar1, L1, R1, q, X, R2, R3, R4, and R5 are as defined, or a pharmaceutically acceptable salt, solvate, or enantiomer thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and related diseases.

Abstract: The present invention relates to a melanin concentrating hormone antagonist compound of formula (I); wherein Ar1, L1, R1, q, X, R2, R3, R4, and R5 are as defined, or a pharmaceutically acceptable salt, solvate, or enantiomer thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and related diseases.

Abstract: The present invention relates to AMPA receptor potentiators of Formula I: formulations comprising them, methods for their use, and intermediates useful for their preparation.

Abstract: A tubular baseball bat comprising a substantially full length core shaft of preferably constant cross-section, including a handle portion, and a barrel with a gap or separation between the core shaft and barrel, the core shaft and barrel being connected at two or more locations. Embodiments include bats with long barrels without taper sections, bats with taper sections integral with the barrels, bats with separate taper sections which may be of non-circular cross-section, bats with flexible circumferential connecting structures, bats with folded barrel end portions, and bats with resilient means between the core shaft and barrel. Such bats can have larger hitting areas, larger sweetspots, higher performance, and provide minimal sting to a player's hands.

Abstract: A light-weight polymer composite endcap, or plug, for a tubular baseball bat provides structural support to the bat barrel end. The endcap permanently bonded to the bat barrel end with a high strength structural adhesive closes off the hollow barrel end. The endcap has a simple geometric shape and has a relatively uniform and thin wall thickness. The light weight achieved by the polymer composite endcap is useful in meeting reduced standards established by regulating bodies and more importantly improves player bat control and swing-speed during the bat swinging phase.

Abstract: A device for satellites is associated with heaters that are turned on when the device is turned off and turned off when the device is turned on. The device includes a power supply, a system for turning the device on and off and a system for turning the heaters on and off controlled by the system for turning the device on and off. The power supply supplies power to the heaters when they are turned on and do not supply power to the heaters to turn on the device. The device is more particularly suited to communication equipment for satellites associated with substitution heaters.