Patents by Inventor Frederic Leroux
Frederic Leroux has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11931719Abstract: The invention discloses a functionalised chromatography medium, comprising: i) at least one non-woven layer (10) of polymeric nano fibres (20) comprising a plurality of nanofibre-nano fibre fusion points (30); ii) a grafted polymer coating covering the polymeric nanofibres and the nanofibre-nanofibre fusion points; iii) a plurality of ligand groups covalently bound to the grafted polymer coating, wherein the ligand groups are capable of interacting with a target biomolecule.Type: GrantFiled: January 7, 2019Date of Patent: March 19, 2024Assignee: PURIDIFY LTD.Inventors: Marc Hummersone, Benjamin Wallis, Frederic Leroux, William Howard Albert Law
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Publication number: 20210346866Abstract: Functionalised polymeric chromatography medium, comprising: at least one non-woven sheet comprising one or more polymeric nanofibers having a mean diameter of 10-1000 nm; one or more polymer chains grafted onto the one or more polymeric nanofibers, wherein the polymer chains are poly-glycerol chains comprising glycidol monomer residues or wherein the polymer chains comprise divinylsulfone monomer residues; and at least one ligand group bonded to the one or more polymer chains.Type: ApplicationFiled: July 15, 2021Publication date: November 11, 2021Inventors: Marc Hummersone, Benjamin Wallis, Frederic Leroux, William Law
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Patent number: 11097252Abstract: The present invention provides a functionalised polymeric chromatography medium, prepared by a process which comprises (i) providing a substrate formed of one or more polymer nanofibres, (ii) grafting one or more neutral polymer chains from the substrate, and (iii) contacting the grafted product with a reagent which functionalises the product of step (ii) as a chromatography medium, wherein step (ii) comprises reacting a plurality of compounds of formula and/or its enantiomers, and/or its derivatives of formula (I) and/or enantiomers and/or diastereomers thereof: with one or more functional groups present on the nanofibre substrate, wherein R1, R2, R3, R4 and R5 may be the same or different, and are chosen from H, halogen, C1-C4 alkyl, or C1-C4 alkoxy provided that at least one of R1, R2, R3, R4 or R5 is not hydrogen.Type: GrantFiled: July 14, 2017Date of Patent: August 24, 2021Assignee: Puridify Ltd.Inventors: Marc Hummersone, Benjamin Wallis, Frederic Leroux, William Law
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Publication number: 20210060527Abstract: The invention discloses a functionalised chromatography medium, comprising: i) at least one non-woven layer (10) of polymeric nano fibres (20) comprising a plurality of nanofibre-nano fibre fusion points (30); ii) a grafted polymer coating covering the polymeric nanofibres and the nanofibre-nanofibre fusion points; iii) a plurality of ligand groups covalently bound to the grafted polymer coating, wherein the ligand groups are capable of interacting with a target biomolecule.Type: ApplicationFiled: January 7, 2019Publication date: March 4, 2021Inventors: Marc Hummersone, Benjamin Wallis, Frederic Leroux, William Howard Albert Law
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Publication number: 20190308169Abstract: The present invention provides a functionalised polymeric chromatography medium, prepared by a process which comprises (i) providing a substrate formed of one or more polymer nanofibres, (ii) grafting one or more neutral polymer chains from the substrate, and (iii) contacting the grafted product with a reagent which functionalises the product of step (ii) as a chromatography medium, wherein step (ii) comprises reacting a plurality of compounds of formula and/or its enantiomers, and/or its derivatives of formula (I) and/or enantiomers and/or diastereomers thereof: with one or more functional groups present on the nanofibre substrate, wherein R1, R2, R3, R4 and R5 may be the same or different, and are chosen from H, halogen, C1-C4 alkyl, or C1-C4 alkoxy provided that at least one of R1, R2, R3, R4 or R5 is not hydrogen.Type: ApplicationFiled: July 14, 2017Publication date: October 10, 2019Inventors: Marc Hummersone, Benjamin Wallis, Frederic Leroux, William Law
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Patent number: 9707553Abstract: P-chirogenic organophosphorus compounds of general formula (I), a process for the synthesis of the compounds of formula (I), and intermediate products of general formulae (II), (III) and (IV), as shown below, are involved in the synthesis of compounds (I). Metal complexes comprising compounds (I) as ligands are also described. The compounds and complexes are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation. Compounds of general formula (I) may be useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.Type: GrantFiled: October 6, 2015Date of Patent: July 18, 2017Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE BOURGOGNE, UNIVERSITE DE STRASBOURG, SYNTHELOR SASInventors: Sylvain Juge, Jerome Bayardon, Emmanuelle Remond, Hugo Laureano, Jean-Christophe Henry, Frederic Leroux, Francoise Colobert
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Publication number: 20160023199Abstract: Novel P-chirogenic organophosphorus compounds of general formula (I), a process for the synthesis of the compounds of formula (I), and intermediate products of general formulae (II), (III) and (IV), as shown below, are involved in the synthesis of compounds (I). Metal complexes including compounds (I) as ligands are also described. The novel compounds and complexes are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation. Compounds of general formula (I) may be useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.Type: ApplicationFiled: October 6, 2015Publication date: January 28, 2016Inventors: Sylvain JUGE, Jerome BAYARDON, Emmanuelle REMOND, Hugo LAUREANO, Jean-Christophe HENRY, Frederic LEROUX, Francoise COLOBERT
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Patent number: 9186661Abstract: Novel P-chirogenic organophosphorus compounds of general formula (I), a process for the synthesis of the compounds of formula (I), and intermediate products of general formulae (II), (III) and (IV), as shown below, are involved in the synthesis of compounds (I). Metal complexes including compounds (I) as ligands are also described. The novel compounds and complexes are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation. Compounds of general formula (I) may be useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.Type: GrantFiled: July 10, 2012Date of Patent: November 17, 2015Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE BOURGOGNE, UNIVERSITE DE STRASBOURG, SYNTHELOR SASInventors: Sylvain Juge, Jerome Bayardon, Emmanuelle Remond, Hugo Laureano, Jean-Christophe Henry, Frederic Leroux, Francoise Colobert
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Patent number: 9174960Abstract: Dibenzylidene and heterobenzylideneacetone derivatives, related 4-piperidones, related 4-thiopyranones and the corresponding sulfinyl- and sulfonyl-analogues for their use for prophylaxis or treatment of trypanosomiasis and leishmaniasis.Type: GrantFiled: September 20, 2010Date of Patent: November 3, 2015Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Elisabeth Davioud-Charvet, Ingrid Nicole Wenzel, Thomas J. J. Müller, Gilles Hanquet, Don Antoine Lanfranchi, Frédéric Leroux, Thibault Gendron
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Publication number: 20140142325Abstract: Novel P-chirogenic organophosphorus compounds of general formula (I), a process for the synthesis of the compounds of formula (I), and intermediate products of general formulae (II), (III) and (IV), as shown below, are involved in the synthesis of compounds (I). Metal complexes including compounds (I) as ligands are also described. The novel compounds and complexes are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation. Compounds of general formula (I) may be useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.Type: ApplicationFiled: July 10, 2012Publication date: May 22, 2014Applicant: Centre National de la Recherche Scientifique(CNRS)Inventors: Sylvain Juge, Jerome Bayardon, Emmanuelle Remond, Hugo Laureano, Jean-Christophe Henry, Frederic Leroux, Francoise Colobert
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Publication number: 20120214996Abstract: Dibenzylidene and heterobenzylideneacetone derivatives, related 4-piperidones, related 4-thiopyranones and the corresponding sulfinyl- and sulfonyl-analogues for their use for prophylaxis or treatment of trypanosomiasis and leishmaniasis.Type: ApplicationFiled: September 20, 2010Publication date: August 23, 2012Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Elisabeth Davioud-Charvet, Ingrid Nicole Wenzel, Thomas J.J. Muller, Gilles Hanquet, Don Antoine Lanfranchi, Frederic Leroux, Thibault Gendron
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Patent number: 7944168Abstract: A device for determining the position of the rotor of a rotating electrical machine. The invention is characterized in that the device comprises a plurality of magnetic field sensors stationary relative to the stator and adapted to deliver multiphase electric signals representing a magnetic field detected by the sensors, and means for processing the multiphase electric signals by an operator capable of providing diphase signals depending on the position of the rotor. The invention is applicable to rotating electrical machines used in the automotive industry.Type: GrantFiled: June 30, 2005Date of Patent: May 17, 2011Assignee: Valeo Equipements Electriques MoteurInventors: Michaël Chemin, Frédéric Leroux, Gilbert Konan
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Patent number: 7895004Abstract: A method and system for measuring electric current in a plurality (n) of conductors. According to the invention, the method comprises the following steps: an electric current transducer is place substantially opposite to each conductor (I, i=1, . . . , n); a decorrelation matrix ([G]), which is a function of the position of the transducers in relation to the conductors, is constructed; the current (Imesi) in each conductor (i) is measured with the aid of electric current transducers and real currents (Iréeli) are deduced with the aid of the decorrelation matrix ([G]) and the measured currents (Imesi).Type: GrantFiled: June 30, 2005Date of Patent: February 22, 2011Assignee: Valeo Equipements Electriques MoteurInventors: Michaël Chemin, Frédéric Leroux, François-Xavier Bernard
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Publication number: 20100137659Abstract: A process for the synthesis of 2,2?,6-tribromobiphenyl.Type: ApplicationFiled: September 26, 2007Publication date: June 3, 2010Inventors: Frédéric Leroux, Laurence Bonnafoux, Francoise Colobert
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Patent number: 7629776Abstract: A control and power module for a rotating electrical machine comprising a power circuit containing a number of branches, and a control circuit designed for controlling the power circuit when the machine operates in a nominal mode. The inventive module is characterized in that the control circuit is also designed for monitoring an output voltage from the power circuit and blocking at least one branch of the power circuit in a conduction state when the output voltage reaches an at least first threshold value so that the machine functions in a degraded mode. The invention is for use in an alternator starter.Type: GrantFiled: August 31, 2005Date of Patent: December 8, 2009Assignee: Valeo Equipments Electriques MoteurInventors: Michael Chemin, Francois-Xavier Bernard, Frederic Leroux
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Publication number: 20090105505Abstract: A process for the preparation of asymmetrically substituted biaryldiphosphine ligands of the formula: wherein R1 is C1-6-alkyl or C3-10-cycloalkyl optionally being substituted with one or more halogen atoms, and R2 and R3 are equal and are C5-10-cycloalkyl and C1-6-alkyl, or R2 is C5-10-cycloalkyl or C1-6-alkyl, and R3 is aryl optionally substituted with one or more substituents selected from the group consisting of halogen atoms, nitro, amino, C1-6-alkyl, C1-6-akoxy and di-C1-6-alkylamino groups,2 and each C1-6-alkyl, C1-6-alkoxy, di-C1-6-alkylamino and C5-10-cycloalkyl group in R2 and R3 is optionally substituted with one or more halogen atoms, from 2,2?,6,6?-tetrabromobiphenyl by a sequence of bromine-metal exchanges and subsequent reactions.Type: ApplicationFiled: June 6, 2005Publication date: April 23, 2009Applicant: LONZA AGInventors: Hanspeter Mettler, Frederic Leroux, Manfred Schlosser
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Publication number: 20090018133Abstract: The invention provides compounds of formula (I), in which m, A, R1 and Ar have the meanings defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy.Type: ApplicationFiled: February 29, 2008Publication date: January 15, 2009Inventors: Rhonan Ford, Frederic Leroux, Michael Stocks
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Publication number: 20080312854Abstract: A method and system for measuring electric current in a plurality (n) of conductors. According to the invention, the method comprises the following steps: an electric current transducer is place substantially opposite to each conductor (I, i=1, . . . , n); a decorrelation matrix ([G]), which is a function of the position of the transducers in relation to the conductors, is constructed; the current (Imesi) in each conductor (i) is measured with the aid of electric current transducers and real currents (Ireeli) are deduced with the aid of the decorrelation matrix ([G]) and the measured currents (Imesi).Type: ApplicationFiled: June 30, 2005Publication date: December 18, 2008Applicant: VALEO EQUIPEMENTS ELECTRIQUES MOTEURInventors: Michael Chemin, Frederic Leroux, Francois-Xavier Bernard
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Publication number: 20080309266Abstract: A device for determining the position of the rotor of a rotating electrical machine. The invention is characterized in that the device comprises a plurality of magnetic field sensors stationary relative to the stator and adapted to deliver multiphase electric signals representing a magnetic field detected by the sensors, and means for processing the multiphase electric signals by an operator capable of providing diphase signals depending on the position of the rotor. The invention is applicable to rotating electrical machines used in the automotive industry.Type: ApplicationFiled: June 30, 2005Publication date: December 18, 2008Applicant: VALEO EQUIPEMENTS ELECTRIQUES MOTEURInventors: Michael Chemin, Frederic Leroux, Gilbert Konan
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Publication number: 20080081809Abstract: There is provided a compound of formula I: , or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.Type: ApplicationFiled: August 21, 2007Publication date: April 3, 2008Applicant: KuDOS Pharmaceuticals LimitedInventors: Heather Duggan, Karine Malagu, Frederic Leroux, Niall Martin, Keith Menear, Graeme Smith