Patents by Inventor Frederic Lhermitte

Frederic Lhermitte has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing 6-alkylated steroidal derivatives and corresponding alkylated 5,6,7,8-tetrahydronaphthalene-2(4 alpha.H)-ones
    Patent number: 9783569
    Abstract: The present invention concerns a method for preparing certain steroidal derivatives alkylated in position 6, comprising a step of alkylating the corresponding compound halogenated in position 6 with an organometallic alkylating agent.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: October 10, 2017
    Assignee: SANOFI
    Inventors: Stéphanie Duez, Jean-Luc Haesslein, Frédéric Lhermitte, Pauline Quinio
  • METHOD FOR PREPARING 6-ALKYLATED STEROIDAL DERIVATIVES AND CORRESPONDING ALKYLATED 5,6,7,8-TETRAHYDRONAPHTHALENE-2(4 ALPHA.H)-ONES
    Publication number: 20160244478
    Abstract: The present invention concerns a method for preparing certain steroidal derivatives alkylated in position 6, comprising a step of alkylating the corresponding compound halogenated in position 6 with an organometallic alkylating agent.
    Type: Application
    Filed: October 28, 2014
    Publication date: August 25, 2016
    Inventors: Stéphanie DUEZ, Jean-Luc HAESSLEIN, Frédéric LHERMITTE, Pauline QUINIO
  • Process for the preparation of a 2-pyridylethylcarboxamide derivative
    Patent number: 8865908
    Abstract: Process for the preparation of a N-[2-(2-pyridinyl)ethyl]carboxamide derivative of general formula (I) or a salt thereof Intermediate of general formula (II) Intermediate of general formula (III)
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: October 21, 2014
    Assignee: Bayer Cropscience AG
    Inventors: Frederic Lhermitte, Pierre-Yves Coqueron, Philippe Desbordes, Thomas Himmler
  • PROCESS FOR THE PREPARATION OF A 2-PYRIDYLETHYLCARBOXAMIDE DERIVATIVE
    Publication number: 20100292485
    Abstract: Process for the preparation of a N-[2-(2-pyridinyl)ethyl]carboxamide derivative of general formula (I) or a salt thereof Intermediate of general formula (II) Intermediate of general formula (III)
    Type: Application
    Filed: July 30, 2010
    Publication date: November 18, 2010
    Applicant: BAYER CROPSCIENCE S.A.
    Inventors: Frédéric LHERMITTE, Pierre-Yves COQUERON, Philippe DESBORDES, Thomas HIMMLER
  • Process for the preparation of a 2-pyridylethylcarboxamide derivative
    Patent number: 7790901
    Abstract: Process for the preparation of a N-[2-(2-pyridinyl)ethyl]carboxamide derivative of general formula (I) or a salt thereof Intermediate of general formula (II) Intermediate of general formula (III).
    Type: Grant
    Filed: December 19, 2005
    Date of Patent: September 7, 2010
    Assignee: Bayer Cropscience S.A.
    Inventors: Frédéric Lhermitte, Pierre-Yves Coqueron, Philippe Desbordes, Thomas Himmler
  • Process for the preparation of a 2-ethylaminopyridine derivative
    Patent number: 7777045
    Abstract: Process for the preparation of a 2-ethylaminopyridine derivative of general formula (I) or a salt thereof Process for the preparation of a N-[2-(2-pyridinyl)ethyl]carboxamide derivative of general formula (II) or a salt thereof Intermediate of general formula (III)
    Type: Grant
    Filed: December 19, 2005
    Date of Patent: August 17, 2010
    Assignee: Bayer Cropscience S.A.
    Inventors: Frédéric Lhermitte, Gilles Perrin-Janet, Paul Dufour, Pierre-Yves Coqueron
  • Process For The Preparation Of A 2-Ethylaminopyridine Derivative
    Publication number: 20080114176
    Abstract: Process for the preparation of a 2-ethylaminopyridine derivative of general formula (I) or a salt thereof Process for the preparation of a N-[2-(2-pyridinyl)ethyl]carboxamide derivative of general formula (II) or a salt thereof Intermediate of general formula (III)
    Type: Application
    Filed: December 19, 2005
    Publication date: May 15, 2008
    Inventors: Frederic Lhermitte, Gilles Perrin-Janet, Paul Dufour, Pierre-Yves Coqueron
  • Process for the Preparation of a 2-Pyridylethylcarboxamide Derivative
    Publication number: 20080086008
    Abstract: Process for the preparation of a N-[2-(2-pyridinyl)ethyl]carbox-amide derivative of general formula (I) or a salt thereof 5 Intermediate of general formula (II) Intermediate of general formula (III).
    Type: Application
    Filed: December 19, 2005
    Publication date: April 10, 2008
    Inventors: Frederic Lhermitte, Pierre-Yves Coqueron, Philippe Desbordes, Thomas HImmler
  • Process for preparing and isolating 9-deoxo-9 (Z)-hydroxyiminoerythromycin A
    Patent number: 6590084
    Abstract: The present invention relates to a process for preparing 9-deoxo-9(Z)-hydroxyiminoerythromycin A corresponding to formula (I) below: from 9-deoxo-9(E)-hydroxyiminoerythromycin A by reaction with a base in water or in a mixture of water/solvent of dialkyl ketone type capable of forming a crystallizable solvate with the desired 9(Z)-oxime; acidification of the reaction mixture to a pH of between 9 and 11; addition to the said mixture of an organic solvent; optionally concentration under vacuum of the resulting organic phase; and isolation of the desired 9(Z)-erythromycin oxime.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: July 8, 2003
    Assignee: Merial
    Inventors: François Basset, Thierry Durand, Ronan Guevel, Patrick Leon, Frédéric Lhermitte, Gilles Oddon, Denis Pauze
  • Process which is useful for converting the carbonyl function in position 4? of the cladinose unit of an aza-macrolide into an amine derivative
    Patent number: 6562953
    Abstract: The invention relates to a process for preparing compound of general formula I by reductive amination of the corresponding (4″)-carbonyl derivative, characterized in that it comprises: placing the said (4″)-carbonyl derivative in contact with at least one nitrogenous reagent and a Lewis acid under conditions that are favourable for converting the 4″ carbonyl function, reducing the resulting mixture using a reducing agent, and optionally deprotecting the hydroxyl function in position 2′, to give the expected compound of general formula I.
    Type: Grant
    Filed: May 16, 2001
    Date of Patent: May 13, 2003
    Assignee: Merial
    Inventors: Jildaz Dhainaut, Patrick Leon, Frédéric Lhermitte, Gilles Oddon
  • Process for the preparation of 9-deoxo-8a-aza-(8a-alkyl)-8a-homoerythromycin A derivatives from 9-deoxo-9 (Z)-hydroxyiminoerythromycin A
    Patent number: 6482931
    Abstract: The invention provides a process for the preparation of 9-deoxo-8a-aza-8a-homoerythromycin A and of its 8a-alkylated derivatives from 9-deoxo-9(Z)-hydroxyiminoerythromycin A via a stereospecific Beckmann rearrangement in a reaction mixture using pyridine as main solvent, resulting in imidate intermediates which are not isolated from said mixture and which are employed directly in a reduction stage using a sufficient amount of borohydride, after extraction of the pyridine with a hydrocarbon which is miscible with the latter and in which said imidates are insoluble. The compound V can be directly N-alkylated at the 8a-position using an aldehyde without being isolated from the reduction mixture.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: November 19, 2002
    Assignee: Merial
    Inventors: Patrick Leon, Frederic Lhermitte, Gilles Oddon, Denis Pauze
  • Process of use in converting the 4?(S)-OH functional group of the cladinose unit of an azamacrolide to 4?(R)-NH2
    Patent number: 6353096
    Abstract: The subject-matter of the invention is a process for the stereoselective preparation of a compound of general formula I by stereoselective displacement by a nitrogenous nucleophilic compound of the activated alcohol functional group present at this 4″ position in a corresponding derivative of formula II.
    Type: Grant
    Filed: January 18, 2000
    Date of Patent: March 5, 2002
    Assignee: Merial
    Inventors: Patrick Leon, Frederic Lhermitte, Ronan Guevel, Denis Pauze, Laurent Garel, Gilles Oddon
  • Process which is useful for converting the carbonyl function in position 4" of the cladinose unit of an aza-macrolide into an amine derivative
    Publication number: 20020013454
    Abstract: The invention relates to a process for preparing compound of general formula I 1
    Type: Application
    Filed: May 16, 2001
    Publication date: January 31, 2002
    Inventors: Jildaz Dhainaut, Patrick Leon, Frederic Lhermitte, Gilles Oddon
  • Process for the preparation of 9-deoxo-8a-aza-(8a-alkyl)-8a-homoerythromycin A derivatives from 9-deoxo-9 (Z)-hydroxyiminoerythromycin A
    Publication number: 20010047088
    Abstract: The invention provides a process for the preparation of 9-deoxo-8a-aza-8a-homoerythromycin A 1
    Type: Application
    Filed: March 22, 2001
    Publication date: November 29, 2001
    Inventors: Patrick Leon, Frederic Lhermitte, Gilles Oddon, Denis Pauze
  • Process for preparing and isolating 9-deoxo-9 (Z)-hydroxyiminoerythromycin A
    Publication number: 20010034434
    Abstract: The present invention relates to a process for preparing 9-deoxo-9(Z)-hydroxyiminoerythromycin A corresponding to formula (I) below: 1
    Type: Application
    Filed: April 23, 2001
    Publication date: October 25, 2001
    Inventors: Francois Basset, Thierry Durand, Ronan Guevel, Patrick Leon, Frederic Lhermitte, Gilles Oddon, Denis Pauze
  • Process of use in converting the 4?(S)-OH functional group of the cladinose unit of an azamacrolide to 4?(R)-NH2
    Patent number: RE40040
    Abstract: The subject-matter of the invention is a process for the stereoselective preparation of a compound of general formula I by stereoselective displacement by a nitrogenous nucleophilic compound of the activated alcohol functional group present at this 4? position in a corresponding derivative of formula II.
    Type: Grant
    Filed: September 9, 2005
    Date of Patent: January 29, 2008
    Assignee: Merial Limited
    Inventors: Patrick Leon, Frederic Lhermitte, Ronan Guevel, Denis Pauze, Laurent Garel, Gilles Oddon