Patents by Inventor Frederic Mallard
Frederic Mallard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10704075Abstract: The invention concerns a method for determining the reaction of at least one bacterium of interest to its exposure to an antibiotic implementing a Raman spectroscopy analysis comprising the following steps: Having a biological sample that could contain said bacteria of interest, Preparing at least two fractions of said sample each comprising one or more living bacteria of interest, Capturing, in each fraction, at least one living bacterium of interest by using a binding partner, Exposing at least one of the fractions to at least one concentration of at least one given antibiotic, the other of the fractions being the control fraction, Submitting the bacterium/bacteria of interest contained in the fractions to an incident light and analyzing the resultant light obtained by Raman diffusion by the bacterium/bacteria of interest by Raman spectroscopy in order to obtain as many Raman spectra as bacteria, Treating said spectra in order to obtain a signature of the reaction of the or each bacterium/bacteria of intType: GrantFiled: November 25, 2016Date of Patent: July 7, 2020Assignees: BIOMÉRIEUX, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventors: Armelle Novelli Rousseau, Isabelle Espagnon, Quentin Josso, Alice Douet, Frédéric Mallard, Olivier Gal
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Publication number: 20180355399Abstract: The invention concerns a method for determining the reaction of at least one bacterium of interest to its exposure to an antibiotic implementing a Raman spectroscopy analysis comprising the following steps: Having a biological sample that could contain said bacteria of interest, Preparing at least two fractions of said sample each comprising one or more living bacteria of interest, Capturing, in each fraction, at least one living bacterium of interest by using a binding partner, Exposing at least one of the fractions to at least one concentration of at least one given antibiotic, the other of the fractions being the control fraction, Submitting the bacterium/bacteria of interest contained in the fractions to an incident light and analyzing the resultant light obtained by Raman diffusion by the bacterium/bacteria of interest by Raman spectroscopy in order to obtain as many Raman spectra as bacteria, Treating said spectra in order to obtain a signature of the reaction of the or each bacterium/bacteria of intType: ApplicationFiled: November 25, 2016Publication date: December 13, 2018Inventors: Armelle NOVELLI ROUSSEAU, Isabelle ESPAGNON, Quentin JOSSO, Alice DOUET, Frédéric MALLARD, Olivier GAL
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Patent number: 9359631Abstract: A method for observing a sample is provided. The method includes the steps of: a) providing a volume (G, V) of a substantially transparent medium having a first refractive index (nint) and having a first surface (S1) that is convex, rounded, or faceted, and a second substantially planar surface (S2), the first surface separating the volume from a surrounding medium (MA) having a second refractive index (nest) that is lower than the first index, the sample to be observed being contained inside the volume or being deposited on the first surface; b) observing the sample through the second substantially planar surface; and c) determining the presence of a substance or an object in the sample by detection during step b), a ring of light that correlates with the volume.Type: GrantFiled: February 16, 2012Date of Patent: June 7, 2016Assignees: Commissariat a L'Energie Atomique et aux Energies Alternatives, BiomerieuxInventors: Mathieu Dupoy, Pierre Joly, Frédéric Mallard, Pierre Marcoux, Raphaël Mathey, Armelle Novelli-Rousseau
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Patent number: 8855397Abstract: The invention relates to a method for detecting clusters of biological particles (12) on a surface (11), comprising steps that involve: a. determining (E1) a topographical representation (20) of said surface; and b. detecting (E3, E4), on said topographical representation, at least one contour defining a region that is likely to correspond to a cluster of biological particles.Type: GrantFiled: April 6, 2011Date of Patent: October 7, 2014Assignees: Commissariat a l'Energie Atomique et aux Energies Alternatives, BiomerieuxInventors: Jean-Pierre Moy, Mathieu Dupoy, Olivier Figadere, Frédéric Pinston, Geneviève Bossy, Laurent Drazek, Maryse Guicherd, Fabien Romanens, Frédéric Mallard
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Publication number: 20130344532Abstract: A method for observing a sample is provided. The method includes the steps of: a) providing a volume (G, V) of a substantially transparent medium having a first refractive index (nint) and having a first surface (S1) that is convex, rounded, or faceted, and a second substantially planar surface (S2), the first surface separating the volume from a surrounding medium (MA) having a second refractive index (next) that is lower than the first index, the sample to be observed being contained inside the volume or being deposited on the first surface; b) observing the sample through the second substantially planar surface; and c) determining the presence of a substance or an object in the sample by detection during step b), a ring of light that correlates with the volume.Type: ApplicationFiled: February 16, 2012Publication date: December 26, 2013Applicant: BIOMERIEUXInventors: Mathieu Dupoy, Pierre Joly, Frédéric Mallard, Pierre Marcoux, Raphaël Mathey, Armelle Novelli-Rousseau
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Publication number: 20130084598Abstract: The invention relates to a method for detecting clusters of biological particles (12) on a surface (11), comprising steps that involve: a. determining (E1) a topographical representation (20) of said surface; and b. detecting (E3, E4), on said topographical representation, at least one contour defining a region that is likely to correspond to a cluster of biological particles.Type: ApplicationFiled: April 6, 2011Publication date: April 4, 2013Applicants: Commissariat A L'Energie Atomique Et Aux Energies Alternatives, BIOMERIEUXInventors: Jean-Pierre Moy, Mathieu Dupoy, Olivier Figadere, Frédéric Pinston, Geneviève Bossy, Laurent Drazek, Maryse Guicherd, Fabien Romanens, Frédéric Mallard
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Patent number: 8216827Abstract: The disclosure relates to a biological analysis device including: means for circulating a fluid to be analyzed, comprising a fluidic chamber, optical detection means based on a semiconductor, including a detection front face, a rear face and pads of electrical contacts located on this rear face.Type: GrantFiled: January 31, 2006Date of Patent: July 10, 2012Assignees: Commissariat a l'Energie Atomique, Biomerieux SAInventors: Patrick Pouteau, Raymond Campagnolo, Frederic Mallard, Frederic Ginot
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Patent number: 8129113Abstract: Analysis chip of at least one analyte, said chip comprising at least one analysis spot for recognition and immobilization specific to the analyte; and a reference range (G) comprising several reference spots each arranged on said chip in a defined manner and independently of one another, each reference spot of this range comprising, immobilized on its surface and in a defined proportion P that is different and known for each spot relative to the other reference spots of said range: a probe reference molecule (PRM) permitting recognition and hybridization specifically to a defined target reference molecule (TRM), and/or an inert oligonucleotide molecule (IM) incapable of recognition and hybridization with said PRM, these molecules both being unable to immobilize said analyte or analytes. The method of the invention comprises the use of said chip with its reference range for analysis of said, at least one, analyte.Type: GrantFiled: December 23, 2004Date of Patent: March 6, 2012Assignee: Commissariat a l'Energie AtomiqueInventors: Frédéric Ginot, Armelle Novelli-Rousseau, Frédéric Mallard, Florence Ricoul
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Publication number: 20090013768Abstract: The disclosure relates to a biological analysis device including: means for circulating a fluid to be analyzed, comprising a fluidic chamber, optical detection means based on a semiconductor, including a detection front face, a rear face and pads of electrical contacts located on this rear face.Type: ApplicationFiled: January 31, 2006Publication date: January 15, 2009Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE, BIOMERIEUX SAInventors: Patrick Pouteau, Raymond Campagnolo, Frederic Mallard, Frederic Ginot
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Publication number: 20080254448Abstract: Analysis chip of at least one analyte, said chip comprising at least one analysis spot for recognition and immobilization specific to the analyte; and a reference range (G) comprising several reference spots each arranged on said chip in a defined manner and independently of one another, each reference spot of this range comprising, immobilized on its surface and in a defined proportion P that is different and known for each spot relative to the other reference spots of said range: a probe reference molecule (PRM) permitting recognition and hybridization specifically to a defined target reference molecule (TRM), and/or an inert oligonucleotide molecule (IM) incapable of recognition and hybridization with said PRM, these molecules both being unable to immobilize said analyte or analytes. The method of the invention comprises the use of said chip with its reference range for analysis of said, at least one, analyte.Type: ApplicationFiled: December 23, 2004Publication date: October 16, 2008Inventors: Frédéric Ginot, Armelle Novelli-Rousseau, Frederic Mallard, Florence Ricoul