Patents by Inventor Frederic P. Hauck

Frederic P. Hauck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4,5-Disubstituted-1-aminoalkyl cyclohexenes
    Patent number: 4131744
    Abstract: Compounds of the formula ##STR1## wherein R is hydrogen, ##STR2## R.sub.1 and R.sub.2 are independently selected from hydrogen, lower alkyl, and cycloalkyl or R.sub.1 and R.sub.2 taken together with the nitrogen atom to which they are attached form a ring of the formula ##STR3## N IS 0 OR AN INTEGER FROM 1 TO 3; M IS AN INTEGER FROM 1 TO 3; R.sub.3 and R.sub.4 are independently selected from hydrogen and lower alkyl; X is hydrogen, halogen, lower alkyl, lower alkoxy, or nitro; and their salts; are disclosed. These compounds possess useful antiinflammatory properties.
    Type: Grant
    Filed: April 25, 1977
    Date of Patent: December 26, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joseph E. Sundeen, Frederic P. Hauck
  • Benzo-cyclitolamines
    Patent number: 4127717
    Abstract: Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein n is 1 or 2; m is 2, 3 or 4; R.sub.1 is alkanoyl; and R.sub.2 is a tertiary amino group; have hypotensive activity.
    Type: Grant
    Filed: March 20, 1978
    Date of Patent: November 28, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Frederic P. Hauck, Joyce Reid
  • Substituted piperidinylpropanols
    Patent number: 4127579
    Abstract: Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein n is 0, 1 or 2; R.sub.1 is alkanoyl; and R.sub.2 is ##STR2## R.sub.3 is alkyl; R.sub.4 is cyano or hydroxy; R.sub.5 is hydroxy or alkanoyloxy; R.sub.6 is hydrogen or alkanoyl; and m is 2, 3 or 4; have useful hypotensive properties.
    Type: Grant
    Filed: November 25, 1977
    Date of Patent: November 28, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Frederic P. Hauck, Rita T. Fox, John R. Watrous
  • Diene intermediates for indantetrols
    Patent number: 4127578
    Abstract: Diene intermediates for indantetrols are provided having the structure ##STR1## wherein X is a single bond or a straight or branched chain alkylene group containing from 1 to 10 carbons, Y is ##STR2## wherein R.sub.7 is hydrogen, lower alkyl, arylalkyl or lower alkoxy and ##STR3## is taken together to form a piperidyl or pyrrolidyl radical, R.sub.8 and R'.sub.8 are lower alkyl or monocyclic cycloalkyl, n is 1 to 3, m and m' are 0, 1 or 2.
    Type: Grant
    Filed: September 12, 1977
    Date of Patent: November 28, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Frederic P. Hauck, Joyce Reid, Venkatachala L. Narayanan, Christopher M. Cimarusti, Rudiger D. Haugwitz, Joseph E. Sundeen
  • Cyclohexanetetrol alkanoates
    Patent number: 4103094
    Abstract: Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sub.1 is alkanoyl; R.sub.2 is alkyl; R.sub.3 is alkylamino, dialkylamino, a 1-piperazinyl group, 4-aryl-1,2,3,6-tetrahydro-1-pyridinyl, or N-alkyl-N-(pyridinylalkyl)amino; and n is 1, 2 or 3; have useful hypotensive activity.
    Type: Grant
    Filed: May 10, 1977
    Date of Patent: July 25, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Frederic P. Hauck, Rita T. Fox
  • Cyclitolamines
    Patent number: 4103095
    Abstract: Compounds having the structure ##STR1## wherein R.sub.1 is alkyl or arylalkyl; R.sub.2 is --C.tbd.N, --C.tbd.CH or ##STR2## wherein R.sub.4 is hydrogen, alkyl, aryl, or arylalkyl; R.sub.3 is alkanoyl; m is 1, 2, 3, or 4; n is 1, 2, or 3; and p is 0, 1, 2 or 3; are useful for the treatment of hypertension.
    Type: Grant
    Filed: July 5, 1977
    Date of Patent: July 25, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Frederic P. Hauck, Joyce Reid
  • Substituted piperazinopropanols
    Patent number: 4101723
    Abstract: Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sub.1 is alkanoyl; R.sub.2 is aryl or pyridinyl; and n is 0, 1 or 2; have useful hypotensive properties.
    Type: Grant
    Filed: April 5, 1977
    Date of Patent: July 18, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Frederic P. Hauck, Rita T. Fox, John R. Watrous
  • Esters of 4-[3-(substituted amino)-2-hydroxypropoxy]-5,6,7,8-tetrahydro-1,6,7-naphthalenetriols
    Patent number: 4093814
    Abstract: Compounds having the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen or acyl, and R.sub.4 is lower alkyl have utility in the treatment of coronary diseases.
    Type: Grant
    Filed: May 18, 1977
    Date of Patent: June 6, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Frederic P. Hauck, Michael E. Condon, Rita T. Fox
  • Phenylpiperazinotetrahydronaphthols and derivatives
    Patent number: 4081444
    Abstract: Compounds having the structure ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sub.1 is hydrogen, ##STR2## wherein X is alkyl or aryl, or ##STR3## wherein Y is alkyl or aryl; R.sub.2 is hydrogen, halogen, alkyl, hydroxy, alkoxy or ##STR4## R.sub.3 is hydrogen, halogen, alkyl, alkoxy, alkylthio, trifluoromethyl, or nitro; and n is 1, 2, or 3, have useful pharamacological properties.
    Type: Grant
    Filed: January 21, 1977
    Date of Patent: March 28, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Michael E. Condon, Frederic P. Hauck, Joyce Reid
  • Cyclitolamines
    Patent number: 4065485
    Abstract: Compounds having the structure ##STR1## wherein R.sub.1 is alkyl or arylalkyl; R.sub.2 is --C.tbd.N, --C.tbd.CH or ##STR2## wherein R.sub.4 is hydrogen, alkyl, aryl, or arylalkyl; R.sub.3 is alkanoyl; m is 1, 2, 3, or 4; n is 1, 2, or 3; and p is 0, 1, 2 or 3; are useful for the treatment of hypertension.
    Type: Grant
    Filed: October 26, 1976
    Date of Patent: December 27, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Frederic P. Hauck, Joyce Reid
  • 4-[3-(Substituted amino)-2-hydroxypropoxy]-5,6,7,8-tetrahydro-1,6,7-naphthalenetriols
    Patent number: 4048231
    Abstract: Compounds having the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen or acyl, and R.sub.4 is lower alkyl having utility in the treatment of coronary diseases.
    Type: Grant
    Filed: February 9, 1976
    Date of Patent: September 13, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Frederic P. Hauck, Michael E. Condon, Rita T. Fox
  • Esters of tetrahydronaphthyloxy-aminopropanols
    Patent number: 4029676
    Abstract: Compounds having the formula ##STR1## wherein R.sup.1 is lower alkyl; R.sup.3, R.sup.4, R.sup.5, R.sup.6, and R.sup.7 are the same or different and are hydrogen or lower alkyl; R.sup.8, R.sup.9, and R.sup.10 are the same or different and are hydrogen, lower alkyl, lower alkoxy or cycloalkyl; and R.sup.11 is acyl; are useful in the treatment of coronary diseases.
    Type: Grant
    Filed: November 6, 1975
    Date of Patent: June 14, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Frederic P. Hauck, Christopher M. Cimarusti, Venkatachala L. Narayanan
  • Phenylpiperazinotetrahydronaphthols and derivatives
    Patent number: 4018773
    Abstract: Compounds having the structure ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sub.1 is hydrogen, ##STR2## wherein X is alkyl or aryl, or ##STR3## wherein Y is alkyl or aryl; R.sub.2 is hydrogen, halogen, alkyl, hydroxy, alkoxy or ##STR4## R.sub.3 is hydrogen, halogen, alkyl, alkoxy, alkylthio, trifluoromethyl, or nitro; and n is 1, 2, or 3, have useful pharmacological properties.
    Type: Grant
    Filed: September 15, 1975
    Date of Patent: April 19, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Michael E. Condon, Frederic P. Hauck, Joyce Reid
  • 2,3-Trans-5-[3-(amino)-2-hydroxy-propoxy]-1,2,3,4-tetrahydro-3-(or 2)-amino-2-(or 3)-hydroxy-naphthalenes and salts thereof
    Patent number: 4003930
    Abstract: This invention relates to novel cyclic polymethylene phenoxy-aminopropanols having the structure ##STR1## and the pharmaceutically acceptable salts of said compounds, wherein R.sup.1, R.sup.2, R.sup.8 and R.sup.9 are each independently selected from hydrogen, lower alkyl and aryl-lower alkyl and R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are each independently selected from hydrogen and lower alkyl, which are useful in the treatment of coronary diseases.
    Type: Grant
    Filed: February 28, 1974
    Date of Patent: January 18, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Frederic P. Hauck, Christopher M. Cimarusti, Joseph E. Sundeen
  • Compositions for the treatment of coronary diseases containing tetrahydronaphthyloxy-aminopropanols
    Patent number: 3982021
    Abstract: This invention relates to pharmaceutical compositions for the treatment of coronary diseases comprising a compound having the formula ##SPC1##Wherein R.sup.1 is lower alkyl, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are the same or different and are hydrogen or lower alkyl, and R.sup.8, R.sup.9 and R.sup.10 are the same or different and are hydrogen, lower alkyl, lower alkoxy or cycloalkyl; and a pharmaceutically acceptable carrier therefor.
    Type: Grant
    Filed: October 9, 1975
    Date of Patent: September 21, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Frederic P. Hauck, Christopher M. Cimarusti, Venkatachala L. Narayanan
  • Cyclitolamines
    Patent number: 3971823
    Abstract: Compounds having the structure ##SPC1##Wherein R.sub.1 is alkyl or arylalkyl; R.sub.2 is hydrogen, halogen, alkyl, or alkoxy; R.sub.3 is alkanoyl; R.sub.4 is hydrogen or alkanoyl; n is 1, 2 or 3; m is 1, 2, 3 or 4; and p is 2, 3 or 4; are useful for the treatment of hypertension.
    Type: Grant
    Filed: December 2, 1975
    Date of Patent: July 27, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Frederic P. Hauck, Joseph E. Sundeen, Joyce Reid