Abstract: Compounds are provided having the structure ##STR1## wherein n is 1 or 2, n.sup.1 is 0, 1 or 2 and n.sup.2 is 0, 1, 2 or 3, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##STR2## amido ##STR3## or lower alkoxyalkylene, R can be lower alkoxy, lower alkyl or cycloalkyl, R.sub.8 can be hydrogen, lower alkyl, cycloalkyl, hydroxy, dialkylaminoalkyl or R.sub.9 O(CH.sub.2)q-. X is a single bond or a straight or branched bivalent aliphatic radical and Y is ##STR4## These compounds are useful in the treatment of hypertension.

Abstract: Imidazo[2,1-b]thiazole derivatives are provided having the structure ##STR1## wherein R.sup.1 is hydrogen, lower alkyl or carboxy, and R.sup.2 is hydrogen, lower alkyl or phenyl.In addition, a method is provided for treating or inhibiting helminthiasis by parenterally, perorally or topically administering a pharmaceutical composition containing such imidazo[2,1-b]thiazole derivatives. Pharmaceutical compositions for use in the above method are also provided.

Abstract: Compounds are provided having the structure ##STR1## WHEREIN N IS 1, 2 OR 3, M AND M' ARE 0, 1 OR 2, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##STR2## or lower alkoxyalkylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR3## These compounds are useful in the treatment of hypertension.

Abstract: Compounds are provided of the structure ##STR1## WHEREIN X--Z--Y together with two carbons of the cycloalkyl ring form a 5- or 6-membered ring, wherein R.sup.1 is hydrogen, aralkyl or acyl, n is 0, 1 or 2, and n' is 0, 1, 2 or 3, R.sup.2 is hydrogen, lower alkyl or aralkyl, R.sup.3 is hydrogen, acyl, lower alkyl, aralkyl, lower alkoxy, carboxy, halo, alkenyl, nitro, cycloalkyl, amino, acylamino, R.sup.2 O(CH.sub.2).sub.n 2 where n.sup.2 is 0, 1 or 2 or dihydroxyalkyl, X and Y may be the same or different and can be --CH.sub.2 --, .dbd.N--, --O--, --S--, --NR.sup.4 --, --O--CH.sub.2 --, --S--CH.sub.2 --, or --NR.sup.4 --CH.sub.2 -- where R.sup.4 is hydrogen, lower alkyl or aryl, Z can be ##STR2## where R.sup.5 and R.sup.6 can be hydrogen, lower alkyl, cycloalkyl, aryl, haloalkyl, amino or substituted or unsubstituted aminoalkyl; ##STR3## and --X--Z--Y-- can be taken together to form ##STR4## and ##STR5## These compounds are useful as anti-fibrillatory agents, disinfectants and water-softeners.

Abstract: The compounds of the invention have the formula ##STR1## wherein Y is a radical of the formula ##STR2## or of the formula ##STR3## WHEREIN (CH.sub.2) is a straight or branched chain alkyl radical, n is 1-6, m is 0 or 1 and R.sup.5 and R.sup.6 may be the same or different and may be hydrogen, alkyl, arylalkyl, and R.sup.5', R.sup.5 and R.sup.6 may be the same or different and may be the nitrogen to which they are attached may be pyrrolidino, piperidino or N'-alkyl piperazino;R.sup.1, r.sup.2, r.sup.3 or R.sup.4 may be the same or different and may be hydrogen; alkyl, trifluoromethyl; alkanoyl; haloalkanoyl; alkoxycarbonyl of the formula ##STR4## wherein R is an alkyl radical; alkoxyalkyl; aminoalkanoyl of the formula ##STR5## wherein R.sup.5 and R.sup.6 are as previously defined and p is 0-3; 2-, 3-, or 4-pyridylcarbonyl; phenyl; monosubstituted phenyl wherein the substituent is alkyl, alkoxy, hydroxy, nitro, amino, or dialkylamino; alkenoyl; or aroyl; radical of 1-6 carbon atoms;R.sup.7 and R.sup.

Abstract: 5,6,7,8-Tetrahydronaphthalenes having the structure ##STR1## and the pharmaceutically acceptable salts thereof, are useful as blood pressure lowering agents. In the above formula R.sub.1 can be hydrogen or alkyl; R.sub.2 is alkyl; R.sub.3 and R.sub.4 can each be hydrogen, hydroxyl, alkoxy, or arylalkoxy, but both cannot be hydroxyl. Those compounds wherein at least one of R.sub.3 and R.sub.4 is other than hydrogen are novel, and constitute a part of this invention.

Abstract: Compounds are provided having the structure ##STR1## wherein n is 1, 2 or 3, m is 0, 1 or 2, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 may be the same or different and can be hydrogen, lower alkyl, halo-lower alkyl, acyl, lower alkoxy-carbonyl ##STR2## amido ##STR3## or lower alkoxyalkylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR4## These compounds are useful in the treatment of hypertension.

Abstract: Compounds are provided having the structure ##STR1## WHEREIN N IS 1, 2 OR 3, M AND M' ARE 0, 1, OR 2, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##STR2## or lower alkoxyalkylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR3## These compounds are useful in the treatment of hypertension.

Abstract: Various piperidone intermediates of the formula ##STR1## wherein R.sub.2 is hydrogen, lower alkyl, lower alkenyl, aryl-lower alkyl, or styryl; and aryl is phenyl, naphthyl, substituted phenyl or substituted naphthyl are disclosed. These compounds are useful as intermediates in the preparation of pharmaceutically useful aryldecahydropyrrolo[3,4-f]-quinolines.

Abstract: The compounds of the invention have the formula ##STR1## wherein Y is a radical of the formula ##STR2## WHEREIN (CH.sub.2) is a straight or branched chain alkyl radical, n is 1-6, m is 0 or 1 and R.sup.5.sup..degree. is hydrogen, alkyl, arylalkyl, and R.sup.5 and R.sup.6 together with the nitrogen to which they are attached may be pyrrolidino, piperidino or N'-alkyl piperazino;R.sup.1, r.sup.2, r.sup.3 and R.sup.4 may be the same or different and may be hydrogen; alkyl, trifluoromethyl; alkanoyl; haloalkanoyl; alkoxycarbonyl of the formula ##STR3## wherein R is an alkyl radical; alkoxyalkyl; aminoalkanoyl of the formula ##STR4## wherein R.sup.5 and R.sup.6 are as previously defined and p is 0--3; 2--, 3--, or 4--pyridylcarbonyl; phenyl; monosubstituted phenyl wherein the substituent is alkyl, alkoxy, hydroxy, nitro, amino, or dialkylamino; alkenoyl; or aroyl;R.sup.9 may be H, or a straight or branched chain alkyl radical of 1-6 carbon atoms;R.sup.7 and R.sup.

Abstract: The compounds of the invention have the formula ##STR1## wherein Y is a radical of the formula ##STR2## or of the formula ##STR3## wherein (CH.sub.2) is a straight or branched chain alkyl radical, n is 1-6, m is 0 or 1 and R.sup.5 and R.sup.6 may be the same or different and may be hydrogen, alkyl, arylalkyl, and R.sup.5 and R.sup.6 together with the nitrogen to which they are attached may be pyrrolidino, piperadino or N'-alkyl piperazino;R.sup.1, r.sup.2, r.sup.3 or R.sup.4 may be the same or different and may be hydrogen; alkyl, trifluoromethyl; alkanoyl; haloalkanoyl; alkoxycarbonyl of the formula ##STR4## wherein R is an alkyl radical; alkoxyalkyl; aminoalkanoyl of the formula ##STR5## wherein R.sup.5 and R.sup.6 are as previously defined and p is 0-3; 2-, 3-, or 4-pyridylcarbonyl; phenyl; monosubstituted phenyl wherein the substituent is alkyl, alkoxy, hydroxy, nitro, amino, or dialkylamino; alkenoyl; or aroyl;R.sup.7 and R.sup.8 may be the same or different and may be hydrogen or alkyl, and R.sup.

Abstract: Compounds are provided having the structure ##SPC1##Wherein n is 1, 2 or 3, m and m' are 0, 1 or 2, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##EQU1## amido ##EQU2## or lower alkoxyalkylene, X is a straight or branched bivalent aliphatic radical and Y is ##EQU3## These compounds are useful in the treatment of hypertension.

Abstract: Compounds are provided having the structure ##SPC1##Wherein n is 1 or 2, n.sup.1 is 0, 1 or 2 and n.sup.2 is 0, 1, 2 or 3, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##EQU1## amido ##EQU2## or lower alkoxyalkylene, R can be lower alkoxy, lower alkyl or cycloalkyl, R.sub.8 can be hydrogen, lower alkyl, cycloalkyl, hydroxy, dialkylaminoalkyl or R.sub.9 O(CH.sub.2)q--. X is a single bond or a straight or branched bivalent aliphatic radical and Y is ##EQU3## These compounds are useful in the treatment of hypertension.

Abstract: 1,2,3,4,6,7,8,8a-Octahydro-6-phenyl or substituted phenyl-isoquinolines and derivatives thereof and their methods of preparation are disclosed. These compounds are useful as anti-inflammatory agents.

Abstract: Various intermediates useful in the preparation of 4-aryl-2,3,3a,4,5,6,7,8,9,9b-decahydro-1H-pyrrolo[3,4-f]quinolines are disclosed.

Abstract: Compounds are provided having the structure: ##SPC1##And to salts of such compounds. These compounds are useful as hypocholesteremic agents and anti-inflammatory agents.

Abstract: The compounds of the invention have the formula ##SPC1##Wherein Y is a radical of the formula ##SPC2##Wherein n is 1, 2, 3, 4, 5, or 6, m is 0 or 1, and R.sup.5 is hydrogen or alkyl of 1 to 3 carbons;R.sup.1, r.sup.2, r.sup.3 and R.sup.4 are the same or different and are alkanoyl of 1 to 4 carbons; haloalkanoyl of 1 to 4 carbons; or alkoxycarbonyl of the formula ##EQU1## wherein R is an alkyl radical of 1 to 4 carbons; R.sup.7 and R.sup.8 are the same or different and are hydrogen or alkyl having 1 to 4 carbon atoms; andR.sup.9 is hydrogen or a straight or branched chain alkyl radical having 1 to 6 carbon atoms.These compounds have been found useful in the treatment of hypertension in mammalian species, as surface active agents, as in vivo antibacterial compounds and as water softeners.

Abstract: This invention relates to new tetrahydronaphthyloxy-aminopropanols and related compounds of the formula ##SPC1##And to salts of such compounds, which are useful in coronary diseases.