Patents by Inventor Frederic Vigneault

Frederic Vigneault has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNA-guided systems for probing and mapping of nucleic acids
    Patent number: 12018321
    Abstract: Methods of detecting, probing, mapping and directed sequencing of target nucleic acids are provided using a guide RNA and a Cas9 protein. Methods for detecting the binding of the guide RNA/Cas9 complex to a target nucleic acid where the guide RNA includes a 3? tail sequence that can hybridize to a probe are provided. Methods for detecting the binding of the guide RNA/Cas9 complex to a target nucleic acid where the complex is physically detected are provided.
    Type: Grant
    Filed: December 8, 2020
    Date of Patent: June 25, 2024
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Frederic Vigneault, Kalim U. Mir
  • Spatial sequencing of nucleic acids using DNA origami probes
    Patent number: 11473139
    Abstract: A method of sequencing nucleic acids is provided using DNA origami as a barcode for a nucleic acid probe.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: October 18, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Richard C. Terry, Frederic Vigneault
  • Sequencing by Structure Assembly
    Publication number: 20220251642
    Abstract: A method of sequencing nucleic acids is provided using sequencing by ligation and/or sequencing by hybridization.
    Type: Application
    Filed: April 8, 2022
    Publication date: August 11, 2022
    Inventors: George M. Church, Richard C. Terry, Frederic Vigneault, Francois Vigneault
  • Sequencing by structure assembly
    Patent number: 11312992
    Abstract: A method of sequencing nucleic acids is provided using sequencing by ligation and/or sequencing by hybridization.
    Type: Grant
    Filed: November 25, 2019
    Date of Patent: April 26, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Richard C. Terry, Frederic Vigneault, Francois Vigneault
  • IN VITRO DETECTION OF NUCLEIC ACID
    Publication number: 20210164025
    Abstract: Described herein are compositions and methods for in vitro detection of nucleic acids. Nucleic acid sensors are activated for cell-free expression of an encoded reporter protein based on the presence of a target nucleic acid. The system is designed to function in low-cost cell extract without the need for instrumentation or stringent temperature control. These features are advantageous for point-of-use molecular diagnostics applications in consumer health, pet/animal health, food safety, and other areas where cost and portability are key factors.
    Type: Application
    Filed: August 14, 2019
    Publication date: June 3, 2021
    Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: William Jeremy BLAKE, Carl W. BROWN, III, James J. COLLINS, Frederic VIGNEAULT
  • RNA-Guided Systems For Probing And Mapping Of Nucleic Acids
    Publication number: 20210102244
    Abstract: Methods of detecting, probing, mapping and directed sequencing of target nucleic acids are provided using a guide RNA and a Cas9 protein. Methods for detecting the binding of the guide RNA/Cas9 complex to a target nucleic acid where the guide RNA includes a 3? tail sequence that can hybridize to a probe are provided. Methods for detecting the binding of the guide RNA/Cas9 complex to a target nucleic acid where the complex is physically detected are provided.
    Type: Application
    Filed: December 8, 2020
    Publication date: April 8, 2021
    Inventors: George M. Church, Frederic Vigneault, Kalim U. Mir
  • Spatial Sequencing of Nucleic Acids Using DNA Origami Probes
    Publication number: 20200248256
    Abstract: A method of sequencing nucleic acids is provided using DNA origami as a barcode for a nucleic acid probe.
    Type: Application
    Filed: March 26, 2020
    Publication date: August 6, 2020
    Inventors: George M. Church, Richard C. Terry, Frederic Vigneault
  • Spatial sequencing of nucleic acids using DNA origami probes
    Patent number: 10640826
    Abstract: A method of sequencing nucleic acids is provided using DNA origami as a barcode for a nucleic acid probe.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: May 5, 2020
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Richard C. Terry, Frederic Vigneault
  • Sequencing by Structure Assembly
    Publication number: 20200080144
    Abstract: A method of sequencing nucleic acids is provided using sequencing by ligation and/or sequencing by hybridization.
    Type: Application
    Filed: November 25, 2019
    Publication date: March 12, 2020
    Inventors: George M. Church, Richard C. Terry, Frederic Vigneault, Francois Vigneault
  • Sequencing by structure assembly
    Patent number: 10501791
    Abstract: A method of sequencing nucleic acids is provided using sequencing by ligation and/or sequencing by hybridization.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: December 10, 2019
    Inventors: George M. Church, Richard C. Terry, Frederic Vigneault, Francois Vigneault
  • RNA-Guided Systems For Probing And Mapping Of Nucleic Acids
    Publication number: 20180320226
    Abstract: Methods of detecting, probing, mapping and directed sequencing of target nucleic acids are provided using a guide RNA and a Cas9 protein. Methods for detecting the binding of the guide RNA/Cas9 complex to a target nucleic acid where the guide RNA includes a 3? tail sequence that can hybridize to a probe are provided. Methods for detecting the binding of the guide RNA/Cas9 complex to a target nucleic acid where the complex is physically detected are provided.
    Type: Application
    Filed: August 19, 2015
    Publication date: November 8, 2018
    Inventors: George M. Church, Frederic Vigneault, Kalim U. Mir
  • Spatial Sequencing of Nucleic Acids Using DNA Origami Probes
    Publication number: 20180230533
    Abstract: A method of sequencing nucleic acids is provided using DNA origami as a barcode for a nucleic acid probe.
    Type: Application
    Filed: February 1, 2018
    Publication date: August 16, 2018
    Inventors: George M. Church, Richard C. Terry, Frederic Vigneault
  • Spatial sequencing of nucleic acids using DNA origami probes
    Patent number: 9914967
    Abstract: A method of sequencing nucleic acids by probe hybridization and/or ligation is provided using DNA origami as a barcode for a nucleic acid probe.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: March 13, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Richard C. Terry, Frederic Vigneault
  • Spatial Sequencing of Nucleic Acids Using DNA Origami Probes
    Publication number: 20150292007
    Abstract: A method of sequencing nucleic acids by probe hybridization and/or ligation is provided using DNA origami as a barcode for a nucleic acid probe.
    Type: Application
    Filed: June 5, 2013
    Publication date: October 15, 2015
    Inventors: George M. Church, Richard C. Terry, Frederic Vigneault
  • Sequencing by Structure Assembly
    Publication number: 20140349294
    Abstract: A method of sequencing nucleic acids is provided using sequencing by ligation and/or sequencing by hybridization.
    Type: Application
    Filed: October 12, 2012
    Publication date: November 27, 2014
    Applicant: President and Fellows of Harvard College
    Inventors: George M. Church, Richard C. Terry, Frederic Vigneault, Francois Vigneault