Patents by Inventor Frederic Zenhausern

Frederic Zenhausern has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210079337
    Abstract: Provided are automated cell culture systems and related in vitro cell culture methods, including for a co-culture of different cell populations having different cell culture conditions. For example, the system may comprise a bioreactor having a plurality of cell culture compartments, the bioreactor having a fluid port fluidly connected to the plurality of cell culture compartments. A pump fluidly connected to the fluid port can provide a cell culture medium to the plurality of culture compartments. A sensor is operably connected to at least one of the plurality of cell culture compartments for measuring at least one cell culture parameter. In this manner, a controller electronically connected the pump and sensor, is configured to automatically adjust a pump flow rate and/or a cell culture gas content to provide a desired steady-state cell culture parameter for facilitating cells interactions and collection of products representative of said interactions.
    Type: Application
    Filed: March 29, 2019
    Publication date: March 18, 2021
    Inventors: Frederic ZENHAUSERN, Matthew W. BARRETT, Carla BROOKS, Peng CHEN, Brett M. DUANE, Marie Oceane PARENT, Stanley D. SMITH, Baiju THOMAS, Jianing YANG
  • Publication number: 20210030347
    Abstract: Provided is an integrated sample collection device for self-collection and analytical pre-processing of a fluid sample, such as a blood sample from a user. A housing is configured to be held by a user, such as a single hand of a user. A contact-activated penetrating member is disposed at least partially in the housing and configured to penetrate skin. A capillary tube is disposed at least partially in the housing and configured to collect blood released by the penetrating member that penetrates the skin. A vacuum-assisted blood collection container can be fluidically connected to the capillary tube for receiving at least a portion of the collected blood. One or more stabilizing/pre-processing agents are provided for stabilizing/pre-processing collected blood in the capillary tube, the vacuum-assisted blood storage container, or both.
    Type: Application
    Filed: April 26, 2019
    Publication date: February 4, 2021
    Inventors: Frederic ZENHAUSERN, Jian GU, Alan NORDQUIST
  • Patent number: 10898896
    Abstract: Provided herein are methods and devices for controlled metering of a volume of fluid into a bioreactor chamber by use of a thermally-activated actuator that provides simultaneous temperature control and fluidic valve capability. The device may be an elastomeric valve assembly comprising: a thermally-activated actuator, a microfluidic cartridge and an elastomeric membrane operably connected to the thermally-activated actuator. Upon thermal activation of the thermally-activated actuator the elastomeric contact surface is forced into a lumen of the conduit of the microfluidic cartridge to fluidically seal the conduit, while the thermally-activated actuator is in thermal contact with a bioreactor chamber.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: January 26, 2021
    Assignee: Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Frederic Zenhausern, Wooseok Jung
  • Publication number: 20200216829
    Abstract: Collection devices and kits for biological sample collection include a biologic sample collection device having a hydrophilic swab matrix that includes a modified polycaprolactone (PCL). Methods of production and use thereof are also described herein. The biologic sample collection devices, kits and methods described herein are used to collect a biologic sample (e.g., blood, buccal cells, etc.) and to enable extraction of nucleic acids (e.g., DNA) from that biologic sample so that the nucleic acids can be analyzed (e.g., sequencing and subsequent analyses of DNA).
    Type: Application
    Filed: December 27, 2019
    Publication date: July 9, 2020
    Inventors: Jeff Morhet, Thomas Kindt, Franco Ferrari, Vasana Maneeratana, Frederic Zenhausern, Sean Grandfield, Beverly L. Wolgast, Alistair McIntyre
  • Patent number: 10519434
    Abstract: Collection devices and kits for biological sample collection include a biologic sample collection device having a hydrophilic swab matrix that includes a modified polycaprolactone (PCL). Methods of production and use thereof are also described herein. The biologic sample collection devices, kits and methods described herein are used to collect a biologic sample (e.g., blood, buccal cells, etc.) and to enable extraction of nucleic acids (e.g., DNA) from that biologic sample so that the nucleic acids can be analyzed (e.g., sequencing and subsequent analyses of DNA).
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: December 31, 2019
    Inventors: Jeff Morhet, Thomas Kindt, Franco Ferrari, Vasana Maneeratana, Frederic Zenhausern, Sean Grandfield, Beverly L. Wolgast, Alistair McIntyre
  • Publication number: 20190370188
    Abstract: Provided herein are biological information pattern (BIP) arrays and related methods for reading out information stored in a biological medium. In this manner, encoded digital information in biomolecular medium can be used as a high data density storage medium that may be read-out and accessed in a label-free manner.
    Type: Application
    Filed: June 4, 2019
    Publication date: December 5, 2019
    Inventors: Frederic Zenhausern, Cedric Hurth
  • Publication number: 20190345431
    Abstract: Provided herein is a microphysiological system that may be used in various cell culture applications and biological system studies, that facilitates co-culture, monitoring, and study of functional interactions among different types of cellular and biological materials under various environmental conditions. The system is configured for fast assembly and disassembly, thereby minimizing damage or contamination of the biological materials and environmental conditions inside the system. The system comprises a base, a lid, and a plurality of clamps that are connected to the base and the lid. The base has a recess surface for receiving cell culture support layers. The lid has a stepped surface configured to exert a contact force to a top layer of one or more cell culture support layers during use. The clamp involves an engagement mechanism that generates a contact force allowing for sealing of the cell culture support layers in a manner that minimizes leakage of fluids.
    Type: Application
    Filed: November 14, 2017
    Publication date: November 14, 2019
    Inventors: Matthew BARRETT, Marc Pol MAC GIOLLA EAIN, Paul WILMES, Frederic ZENHAUSERN
  • Publication number: 20180272347
    Abstract: Provided herein are methods and devices for controlled metering of a volume of fluid into a bioreactor chamber by use of a thermally-activated actuator that provides simultaneous temperature control and fluidic valve capability. The device may be an elastomeric valve assembly comprising: a thermally-activated actuator, a microfluidic cartridge and an elastomeric membrane operably connected to the thermally-activated actuator. Upon thermal activation of the thermally-activated actuator the elastomeric contact surface is forced into a lumen of the conduit of the microfluidic cartridge to fluidically seal the conduit, while the thermally-activated actuator is in thermal contact with a bioreactor chamber.
    Type: Application
    Filed: September 23, 2016
    Publication date: September 27, 2018
    Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Frederic ZENHAUSERN, Wooseok JUNG
  • Publication number: 20180257077
    Abstract: Instruments, devices and methods of analysis are provided which fully integrate a significant number of process steps in a continuous operation. Accurate positioning and full contact between components is also provided by the relative movement the designs allow. An effect interface between a low cost disposable cartridge or device and the instrument to process it is also detailed.
    Type: Application
    Filed: January 10, 2018
    Publication date: September 13, 2018
    Inventors: Frederic ZENHAUSERN, Alan NORDQUIST, Ralf LENIGK, Cedric HURTH, Jianing YANG, Xiaojia CHEN, John LEE-EDGHILL, Nina MORAN, Andrew HOPWOOD, Pieris KOUMI
  • Publication number: 20180155665
    Abstract: Cell culture apparatus for emulating gastrointestinal tract conditions and comprising at least two adjacent, microfluidic, cell cultivation channels separated by a permeable or semipermeable membrane, a first channel carrying gastrointestinal tract epithelial cells or tissues and a second channel carrying luminal and preferably mucosal microbiota, and wherein said second channel comprises one or more dwell chambers capable of providing a location for unattached luminal flora to reside away from any direct flow in said second channel, permits modelling of multiple sections of the gastrointestinal tract and control of retention times.
    Type: Application
    Filed: May 27, 2016
    Publication date: June 7, 2018
    Inventors: Frederic ZENHAUSERN, Paul WILMES, Pranjul SHAH
  • Publication number: 20180127740
    Abstract: Collection devices and kits for biological sample collection include a biologic sample collection device having a hydrophilic swab matrix that includes a modified polycaprolactone (PCL). Methods of production and use thereof are also described herein. The biologic sample collection devices, kits and methods described herein are used to collect a biologic sample (e.g., blood, buccal cells, etc.) and to enable extraction of nucleic acids (e.g., DNA) from that biologic sample so that the nucleic acids can be analyzed (e.g., sequencing and subsequent analyses of DNA).
    Type: Application
    Filed: July 17, 2017
    Publication date: May 10, 2018
    Inventors: Jeff Morhet, Thomas Kindt, Franco Ferrari, Vasana Maneeratana, Frederic Zenhausern, Sean Grandfield, Beverly L. Wolgast, Alistair McIntyre
  • Patent number: 9708600
    Abstract: Collection devices and kits for biological sample collection include a biologic sample collection device having a hydrophilic swab matrix that includes a modified polycaprolactone (PCL). Methods of production and use thereof are also described herein. The biologic sample collection devices, kits and methods described herein are used to collect a biologic sample (e.g., blood, buccal cells, etc.) and to enable extraction of nucleic acids (e.g., DNA) from that biologic sample so that the nucleic acids can be analyzed (e.g., sequencing and subsequent analyzes of DNA).
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: July 18, 2017
    Assignee: DIOMICS CORPORATION
    Inventors: Jeff Morhet, Thomas Kindt, Franco Ferrari, Vasana Maneeratana, Frederic Zenhausern, Sean Grandfield, Beverly L. Wolgast
  • Publication number: 20170087553
    Abstract: A method and device structure are provided which enable an archive sample to be collected and detached relative to a device within which a series of processes, such as PCR are being provided. A chamber structure and method of use are provided in which a controlled and precise volume is obtained by control of the relative resistance to flow through various channels.
    Type: Application
    Filed: September 2, 2016
    Publication date: March 30, 2017
    Inventors: Frederic ZENHAUSERN, Alan NORDQUIST, Ralf LENIGK, Cedric HURTH, Jianing YANG, Xiaojia CHEN, Matthew ESTES, John LEE-EDGHILL, Nina MORAN, Andrew HOPWOOD, Pieris KOUMI, Zhi CAI
  • Publication number: 20170045427
    Abstract: Provided herein are methods and related systems for controlling droplet spreading on a surface, including droplets in which a biological component is suspended. A biological solution is provided as a droplet to a surface. Interference fringes generated by the droplet on the surface are imaged, wherein the imaging is over a time course during which the droplet spreads on the surface. A droplet parameter is determined from the imaging step and a process parameter controlled to obtain an interference fringe pattern corresponding to a desired droplet parameter. In this manner, well-controlled droplet spreading is achieved, which is important in a range of applications, including assays that rely on good metaphase spreading.
    Type: Application
    Filed: February 20, 2015
    Publication date: February 16, 2017
    Applicant: The Arizona Board of Regents On Behalf Of The University of Arizona
    Inventors: Frederic ZENHAUSERN, Jian GU
  • Publication number: 20160281079
    Abstract: Collection devices and kits for biological sample collection include a biologic sample collection device having a hydrophilic swab matrix that includes a modified polycaprolactone (PCL). Methods of production and use thereof are also described herein. The biologic sample collection devices, kits and methods described herein are used to collect a biologic sample (e.g., blood, buccal cells, etc.) and to enable extraction of nucleic acids (e.g., DNA) from that biologic sample so that the nucleic acids can be analyzed (e.g., sequencing and subsequent analyses of DNA).
    Type: Application
    Filed: June 6, 2016
    Publication date: September 29, 2016
    Inventors: Jeff Morhet, Thomas Kindt, Franco Ferrari, Vasana Maneeratana, Frederic Zenhausern, Sean Grandfield, Beverly L. Wolgast
  • Publication number: 20160243542
    Abstract: An apparatus for processing a sample, circuit board suited to use in such an apparatus and a method of processing in which the apparatus has alignment features to assist in aligning the circuit board and a sample cartridge in the correct position relative to one another. In this way, the plurality of sections for processing a sample in the cartridge are positioned against a plurality of elements, such as a heater for heating the sample cartridge or an electrical contact (EP1-EP4) for powering features on the sample cartridge, correctly and can operate independently of one another.
    Type: Application
    Filed: September 18, 2015
    Publication date: August 25, 2016
    Inventors: Stan SMITH, Brett DUANE, Cedric HURTH, David NGUYEN, Amol SURVE, Ralf LENIGK, Frederic ZENHAUSERN
  • Patent number: 9409173
    Abstract: Provided herein are devices and methods for generating microfluidic gradients, including an array of unique microfluidic gradients within an array of microchannels. Fluids within conduits are mixed in an intersection region to generate a mixed flow stream in a source reservoir channel that provides a gradient that varies with axial distance from the intersection region. Microchannels having an inlet connected to the source reservoir channel are configured to provide a microfluidic gradient in the microchannel. An outlet end of the microchannel is connected to a sink reservoir channel. By varying the ratio of fluid flow rates from the fluid conduits, the microchannel gradients are tuned. In this manner, a large number of unique gradients or array of microfluidic gradients is provided, wherein the gradient can be any number of physical or chemical parameters, including concentrations and physical fluid properties.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: August 9, 2016
    Assignee: The Arizona Board of Regents on Behalf of The University of Arizona
    Inventors: Matthew D Estes, Cedric M Hurth, Frederic Zenhausern
  • Publication number: 20160187293
    Abstract: An electrophoresis device where the end of the electrophoresis channel has a part that extends vertically. The electrophoresis channel includes a first access port at one end of the channel and a second port at the other end of the channel, which are in the same horizontal plane. In this way, there is a less than 0.1% hydrostatic pressure differential between two ports and the performance of the device is improved.
    Type: Application
    Filed: June 11, 2012
    Publication date: June 30, 2016
    Applicants: The Arizona Board of Regents acting for and on behalf of University of Arizona, BioAccel
    Inventors: Frederic ZENHAUSERN, Alan NORDQUIST, Ralf LENIGK, Cedric HURTH, Jianing YANG, Xiaojia CHEN, Matthew ESTES, John LEE-EDGHILL, Nina MORAN, Andrew HOPWOOD, Pieris KOUMI
  • Publication number: 20160168623
    Abstract: A method of analysing a sample includes providing a first part of the sample and a second part of the sample. A first analysis is conducted on the first part of the sample and the results of the first analysis are considered. A second analysis is conducted on the second part of the sample, the second analysis being conducted according to a procedure using a value for each of one or more characteristics of the procedure. The consideration of the results of the first analysis is used to determine whether the value for one or more of the characteristics of the procedure is changed to a different value. The second analysis is started before the results of the first analysis are obtained.
    Type: Application
    Filed: July 15, 2015
    Publication date: June 16, 2016
    Inventors: Frederic ZENHAUSERN, Alan NORDQUIST, Ralf LENIGK, Cedric HURTH, Andrew HOPWOOD, Pieris KOUMI, Gill TULLY
  • Patent number: 9359600
    Abstract: Collection devices and kits for biological sample collection include a biologic sample collection device having a hydrophilic swab matrix that includes a modified polycaprolactone (PCL). Methods of production and use thereof are also described herein. The biologic sample collection devices, kits and methods described herein are used to collect a biologic sample (e.g., blood, buccal cells, etc.) and to enable extraction of nucleic acids (e.g., DNA) from that biologic sample so that the nucleic acids can be analyzed (e.g., sequencing and subsequent analyses of DNA).
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: June 7, 2016
    Assignee: Diomics Corporation
    Inventors: Jeff Morhet, Thomas Kindt, Franco Ferrari, Vasana Maneeratana, Frederic Zenhausern