Patents by Inventor Frederick Alt

Frederick Alt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High-throughput mouse model for optimizing antibody affinities
    Patent number: 10034463
    Abstract: Described herein are compositions (e.g. cells and transgenic animals) and methods relating to engineered Ig loci that permit expression of particular antibodies or antibody segments while still permitting recombination and/or maturation process for antibody optimization.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: July 31, 2018
    Assignee: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Frederick Alt, Hwei-Ling Cheng, Ming Tian
  • HIGH-THROUGHPUT MOUSE MODEL FOR OPTIMIZING ANTIBODY AFFINITIES
    Publication number: 20160374320
    Abstract: Described herein are compositions (e.g. cells and transgenic animals) and methods relating to engineered Ig loci that permit expression of particular antibodies or antibody segments while still permitting recombination and/or maturation process for antibody optimization.
    Type: Application
    Filed: January 23, 2015
    Publication date: December 29, 2016
    Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Frederick ALT, Hwei-Ling CHENG, Ming TIAN
  • Methods for extending the replicative lifespan of cells
    Publication number: 20070160586
    Abstract: The present invention is directed to methods for enhancing the replicative capacity of cells, by culturing the cells in the presence of an active agent or compound which inhibits SIRT1. One method provides expanding stem cells by culturing the cells in the presence of a SIRT1 inhibitor. The resulting cultured cells can be used for a variety of applications including cell-based therapies such as bone marrow transplants, gene therapies, tissue engineering, and in vitro organogenesis.
    Type: Application
    Filed: June 14, 2006
    Publication date: July 12, 2007
    Applicant: Children's Medical Center Corporation
    Inventors: Frederick Alt, David Lombard, Katrin Chua, Raul Mostoslavsky, Hwei-Ling Cheng
  • SIRT6 transgenic non-human animals and assay methods
    Publication number: 20050204410
    Abstract: Assay methods for identifying agents capable of modulating SIRT6 activity or expression, as well as non-human transgenic animals useful for identifying agents capable of inhibiting aging-associated degenerative processes.
    Type: Application
    Filed: March 11, 2005
    Publication date: September 15, 2005
    Inventors: Margaret Karow, Raul Mostoslavsky, Frederick Alt