Patents by Inventor Frederick C. Novello

Frederick C. Novello has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted pyranone inhibitors of cholesterol synthesis
    Patent number: 4710513
    Abstract: 6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
    Type: Grant
    Filed: March 14, 1984
    Date of Patent: December 1, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Alvin K. Willard, Frederick C. Novello, William F. Hoffman, Edward J. Cragoe, Jr.
  • Substituted pyranone inhibitors of cholesterol synthesis
    Patent number: 4567289
    Abstract: The methyl, ethyl, n-propy, 2-(acetylamino)ethyl, or 1-(2,3-dihydroxy)propyl ester of E-(3R,5S)-7-(4'-fluoro-3,3',5-trimethyl[1,1'-biphenyl]-2-yl)-3,5-dihydroxy -6-heptenoic acid of structural formula: ##STR1## are HMG-CoA reductase inhibitors useful in the treatment of conditions associated with hypercholesterolemia.
    Type: Grant
    Filed: April 25, 1984
    Date of Patent: January 28, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Alvin K. Willard, Frederick C. Novello, William F. Hoffman, Edward J. Cragoe, Jr.
  • Substituted pyranone inhibitors of cholesterol synthesis
    Patent number: 4459422
    Abstract: 6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
    Type: Grant
    Filed: June 10, 1982
    Date of Patent: July 10, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Alvin K. Willard, Frederick C. Novello, William F. Hoffman, Edward J. Cragoe, Jr.
  • Substituted pyranone inhibitors of cholesterol synthesis
    Patent number: 4375475
    Abstract: 6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
    Type: Grant
    Filed: February 11, 1981
    Date of Patent: March 1, 1983
    Assignee: Merck & Co., Inc.
    Inventors: Alvin K. Willard, Frederick C. Novello, William F. Hoffman, Edward J. Cragoe, Jr.
  • 1,2,4-Triazoles and a method for their preparation
    Patent number: 4256887
    Abstract: Triazoles substituted at the 3 and 5 positions having an optional substituent in the 1 position are provided. Methods of preparing the novel substituted triazoles are described. The substituted triazoles are useful as anti-gout and anti-hyperuricomic agents. Compositions useful in the treatment of gout and hyperuricomia containing a substituted triazole as the active ingredient are also provided.
    Type: Grant
    Filed: September 13, 1979
    Date of Patent: March 17, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Frederick C. Novello, John J. Baldwin
  • 1,2,4-Triazoles
    Patent number: 4198513
    Abstract: Triazoles substituted at the 3 and 5 positions having an optional substituent in the 1 position are provided. Methods of preparing the novel substituted triazoles are described. The substituted triazoles are useful as anti-gout and anti-hyperuricemic agents. Compositions useful in the treatment of gout and hyperuricemia containing a substituted triazole as the active ingredient are also provided.
    Type: Grant
    Filed: April 7, 1978
    Date of Patent: April 15, 1980
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Frederick C. Novello
  • N-alkyl(and cycloalkyl)oxamic acid and derivatives as inhibitors of glycolic acid oxidase
    Patent number: 4187315
    Abstract: N-Alkyl and N-cycloalkyloxamic acid derivatives are disclosed which inhibit glycolic acid oxidase and thus are useful in the treatment and prevention of calcium oxalate urolithiasis (kidney and bladder stone disease).
    Type: Grant
    Filed: October 11, 1978
    Date of Patent: February 5, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Frederick C. Novello, Walfred S. Saari
  • 4-Substituted-2-arylimidazoles
    Patent number: 4179512
    Abstract: 4-Substituted-2-arylimidazoles, wherein the 4-substituent is sulfur containing, are disclosed. The compounds have pharmaceutical activity.
    Type: Grant
    Filed: May 26, 1978
    Date of Patent: December 18, 1979
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Frederick C. Novello
  • 1,2,4-Triazoles
    Patent number: 4156085
    Abstract: Triazoles substituted at the 3 and 5 positions having an optional substituent in the 1 position are provided. Methods of preparing the novel substituted triazoles are described. The substituted triazoles are useful as anti-gout and anti-hyperuricemic agents. Compositions useful in the treatment of gout and hyperuricemia containing a substituted triazole as the active ingredient are also provided.
    Type: Grant
    Filed: February 21, 1978
    Date of Patent: May 22, 1979
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Frederick C. Novello
  • Trifluoromethylimidazoles and a method for their preparation
    Patent number: 4125530
    Abstract: 4(5)-Trifluoromethylimidazoles having optional substituents in the 1 and 2 positions are provided. The novel 4(5)-trifluoromethylimidazoles are prepared by reacting a 1,1-dihalo-3,3,3-trifluoroacetone compound with an appropriate carboxaldehyde and ammonia. The 4(5)-trifluoromethylimidazoles are useful as anti-gout and anti-hyperuricemic agents.
    Type: Grant
    Filed: February 2, 1977
    Date of Patent: November 14, 1978
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Frederick C. Novello
  • Anti-hyperuricemia composition
    Patent number: 4111944
    Abstract: Compositions useful in the treatment of gout and hyperuricemia and containing a substituted 1,2,4-triazole as the active ingredient are provided, the triazoles being substituted at the 5 position with a pyridyl radical and at the 3 position with a phenyl or a pyridyl radical. Methods of preparing these substituted triazoles are described. Certain of the compounds are novel.
    Type: Grant
    Filed: June 21, 1977
    Date of Patent: September 5, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Frederick C. Novello, John J. Baldwin
  • 4-Substituted-2-arylimidazoles
    Patent number: 4110456
    Abstract: 4-Substituted-2-arylimidazoles, wherein the 4-substituent is sulfur containing, are disclosed. The compounds have pharmaceutical activity.
    Type: Grant
    Filed: March 1, 1977
    Date of Patent: August 29, 1978
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Frederick C. Novello
  • 1,3,5-Trisubstituted-1,2,4-triazole compounds
    Patent number: 4104393
    Abstract: Compounds useful in the treatment of asthma, the symptoms of allergy and in some instances in gout and hyperuricemia are described. The novel compounds are 1-substituted-1,2,4-triazoles being additionally substituted at the 3- and 5-positions with a pyridyl radical. Methods of preparing these tri-substituted triazoles are described.
    Type: Grant
    Filed: September 2, 1977
    Date of Patent: August 1, 1978
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Frederick C. Novello
  • 1,2,4-Triazoles
    Patent number: 4102889
    Abstract: Triazoles substituted at the 3 and 5 positions having an optional substituent in the 1 position are provided. Methods of preparing the novel substituted triazoles are described. The substituted triazoles are useful as anti-gout and anti-hyperuricemic agents. Compositions useful in the treatment of gout and hyperuricemia containing a substituted triazole as the active ingredient are also provided.
    Type: Grant
    Filed: November 9, 1976
    Date of Patent: July 25, 1978
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Frederick C. Novello
  • Di-and tri-substituted 1,2,4-triazoles
    Patent number: 4071518
    Abstract: Triazoles substituted at the 3 and 5 positions having an optional substituent in the 1 position are provided. Methods of preparing the novel substituted triazoles are described. The substituted triazoles are useful as anti-gout and anti-hyperuricemic agents. Compositions useful in the treatment of gout and hyperuricemia containing a substituted triazole as the active ingredient are also provided.
    Type: Grant
    Filed: September 13, 1976
    Date of Patent: January 31, 1978
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Frederick C. Novello
  • 1,3,5-Trisubstituted-1,2,4-triazole compounds
    Patent number: 4048183
    Abstract: Compounds useful in the treatment of asthma, the symptoms of allergy and in some instances in gout and hyperuricemia are described. The novel compounds are 1-substituted-1,2,4-triazoles being additionally substituted at the 3- and 5-positions with a pyridyl radical. Methods of preparing these tri-substituted triazoles are described.
    Type: Grant
    Filed: April 2, 1976
    Date of Patent: September 13, 1977
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Frederick C. Novello
  • 2-Pyrazinyl-trifluoromethylimidazoles and a method for their preparation
    Patent number: 4032522
    Abstract: 4(5)-Trifluoromethylimidazoles having optional substituents in the 1 and 2 positions are provided. The novel 4(5)-trifluoromethylimidazoles are prepared by reacting a 1,1-dihalo-3,3,3-trifluoroacetone compound with an appropriate carboxaldehyde and ammonia. The 4(5)-trifluoromethylimidazoles are useful as anti-gout and anti-hyperuricemic agents.
    Type: Grant
    Filed: September 5, 1975
    Date of Patent: June 28, 1977
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Frederick C. Novello
  • 1,2,4-Triazoles
    Patent number: 4011218
    Abstract: Triazoles substituted at the 3 and 5 positions having an optional substituent in the 1 position are provided. Methods of preparing the novel substituted triazoles are described. The substituted triazoles are useful as anti-gout and anti-hyperuricemic agents. Compositions useful in the treatment of gout and hyperuricemia containing a substituted triazole as the active ingredient are also provided.
    Type: Grant
    Filed: December 3, 1974
    Date of Patent: March 8, 1977
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Frederick C. Novello
  • 3-Diazine substituted benzothiadiazines
    Patent number: 3988324
    Abstract: 3-Diazine(or substituted diazine)-1,2,4-benzothiadiazine-1,1-dioxide products or 3,4-dihydro derivatives thereof are described. Products are prepared by conventional methods employing the appropriate sulfamoylaniline and diazine carboxylic acid halide or diazine carboxaldehyde. Products are xanthine oxidase inhibitors.
    Type: Grant
    Filed: August 29, 1975
    Date of Patent: October 26, 1976
    Assignee: Merck & Co., Inc.
    Inventor: Frederick C. Novello
  • 1,3,5-Trisubstituted-1,2,4-triazole compounds used as bronchodilators
    Patent number: 3984558
    Abstract: Compounds useful in the treatment of asthma, the symptoms of allergy and in some instances in gout and hyperuricemia are described. The novel compounds are 1-substituted-1,2,4-triazoles being additionally substituted at the 3- and 5-positions with a pyridyl radical. Methods of preparing these tri-substituted triazoles are described.
    Type: Grant
    Filed: November 29, 1974
    Date of Patent: October 5, 1976
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Frederick C. Novello