Patents by Inventor Frederick DEAR

Frederick DEAR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHIMERIC ANTIGEN RECEPTOR SPECIFIC FOR HLA
    Publication number: 20230226182
    Abstract: A vector comprising a first polynucleotide encoding a FOXP3 polypeptide and a second polynucleotide encoding a chimeric antigen receptor (CAR), wherein the CAR comprises an antigen recognition domain which specifically binds to a human leukocyte antigen (HLA), wherein the first polynucleotide and the second polynucleotide are operably linked to the same promoter, and wherein the first polynucleotide is upstream of the second polynucleotide.
    Type: Application
    Filed: October 23, 2020
    Publication date: July 20, 2023
    Inventors: Hans STAUSS, Emma MORRIS, Jenny MCGOVERN, Elisa PETRIS, Frederick DEAR
  • CHIMERIC RECEPTORS FOR USE IN ENGINEERED CELLS
    Publication number: 20230138428
    Abstract: The present invention provides a nucleic acid molecule comprising a polynucleotide sequence encoding a chimeric receptor, particularly a chimeric antigen receptor (CAR), wherein said chimeric receptor comprises an endodomain comprising (i) a STAT5 association motif, and a JAK1 and/or JAK2 binding motif and (ii) a JAK3 binding motif, wherein (i) and (ii) are connected by a linker or hinge.
    Type: Application
    Filed: February 24, 2021
    Publication date: May 4, 2023
    Inventors: Marc MARTINEZ-LLORDELLA, Elisa PETRIS, Frederick DEAR, Maria ALONSO-FERRERO