Patents by Inventor Frederick Dombrose

Frederick Dombrose has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunoassay for F1.2 prothrombin fragment
    Patent number: 6541275
    Abstract: According to the present invention highly specific-low affinity antibodies are generated which allow for the assay of F1.2 in bodily fluids that also contain prothrombin or other plasma proteins. Antibodies having the necessary properties for this assay are made using synthetic polypeptides which mimic the carboxy terminus of F1.2.
    Type: Grant
    Filed: February 3, 1988
    Date of Patent: April 1, 2003
    Assignee: Dade Behring Inc.
    Inventors: Juan A. Ruiz, James R. Maynard, Frederick Dombrose
  • Immunoassays for and monoclonal antibodies to prothrombin activation peptide F1.2
    Patent number: 5830681
    Abstract: Monoclonal antibodies and fragments thereof, with binding specificity for an epitope on the carboxy terminus of prothrombin activation peptide F1.2, which can be used in immunoassays to predict thrombosis by measuring the extent of activation of prothrombin. These monoclonal antibodies are also included in a kit for performing such immunoassays.
    Type: Grant
    Filed: December 30, 1993
    Date of Patent: November 3, 1998
    Assignee: Akzo Nobel N.V.
    Inventors: Marcie J. Hursting, Bryan T. Butman, Jerald P. Steiner, Bryant M. Moore, Frederick A. Dombrose