Patents by Inventor Frederick F. Lang

Frederick F. Lang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240245614
    Abstract: Aspects of the disclosure encompass systems, methods, and compositions for producing exosomes from mesenchymal stem cells and, optionally, loading said exosomes with one or more therapeutic agents. The systems, methods, and compositions may occur in an automated cell expansion system that allows for controllable parameters and from which cells and exosomes may be harvested at one or more times as part of a particular regimen. The exosomes may be loaded with one or more therapeutic agents using electroporation. In specific aspects, the exosomes may be provided to an individual in need thereof, including in some cases where the individual in need thereof is an individual having a medical disorder for which the exosomes would be therapeutic.
    Type: Application
    Filed: May 17, 2022
    Publication date: July 25, 2024
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Frederick F. LANG, Elizabeth J. SHPALL, Katy REZVANI, Mayela MENDT, Daniel LEDBETTER, Joy GUMIN, Brittany PARKER KERRIGAN, Anwar HOSSAIN, Frederick M. LANG
  • Patent number: 10080774
    Abstract: The present invention involves compositions and methods for treating cancer using a mutant adenovirus comprising a polynucleotide encoding a therapeutic polypeptide that is targeted to cells with a mutant retinoblastoma pathway. The mutant adenovirus is able to kill the tumor cells without harming cells with a wild type retinoblastoma pathway.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: September 25, 2018
    Assignee: Board of Regents, The University of Texas System
    Inventors: Juan Fueyo, Candelaria Gomez-Manzano, W. K. Alfred Yung, Charles A. Conrad, Frederick F. Lang, Jr.
  • Publication number: 20150306160
    Abstract: The present invention involves compositions and methods for treating cancer using a mutant adenovirus comprising a polynucleotide encoding a therapeutic polypeptide that is targeted to cells with a mutant retinoblastoma pathway. The mutant adenovirus is able to kill the tumor cells without harming cells with a wild type retinoblastoma pathway.
    Type: Application
    Filed: May 4, 2015
    Publication date: October 29, 2015
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Juan FUEYO, Candelaria GOMEZ-MANZANO, W. K. Alfred YUNG, Charles A. CONRAD, Frederick F. LANG, JR.
  • Patent number: 9061055
    Abstract: The present invention involves compositions and methods for treating cancer using a mutant adenovirus comprising a polynucleotide encoding a therapeutic polypeptide that is targeted to cells with a mutant retinoblastoma pathway. The mutant adenovirus is able to kill the tumor cells without harming cells with a wild type retinoblastoma pathway.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: June 23, 2015
    Assignee: Board of Regentsm The University of Texas System
    Inventors: Juan Fueyo, Candelaria Gomez-Manzano, W.K. Alfred Yung, Charles A. Conrad, Frederick F. Lang, Jr.
  • Patent number: 8926750
    Abstract: A method for synthesizing ZnO, comprising continuously circulating a growth solution that is saturated with ZnO between a warmer deposition zone, which contains a substrate or seed, and a cooler dissolution zone, which is contains ZnO source material.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: January 6, 2015
    Assignee: The Regents of the University of California
    Inventors: Jacob J. Richardson, Frederick F. Lange
  • Patent number: 8841691
    Abstract: A method of fabricating a Light Emitting Diode with improved light extraction efficiency, comprising depositing a plurality of Zinc Oxide (ZnO) nanorods on one or more surfaces of a III-Nitride based LED, by growing the ZnO nanorods from an aqueous solution, wherein the surfaces are different from c-plane surfaces of III-Nitride and transmit light generated by the LED.
    Type: Grant
    Filed: August 19, 2013
    Date of Patent: September 23, 2014
    Assignee: The Regents of the University of California
    Inventors: Jacob J. Richardson, Daniel B. Thompson, Ingrid Koslow, Jun-Seok Ha, Frederick F. Lange, Steven P. DenBaars, Shuji Nakamura
  • Publication number: 20140103361
    Abstract: A high brightness III-Nitride based Light Emitting Diode (LED), comprising multiple surfaces covered by Zinc Oxide (ZnO) layers, wherein the ZnO layers are grown in a low temperature aqueous solution and each have a (0001) c-orientation and a top surface that is a (0001) plane.
    Type: Application
    Filed: December 19, 2013
    Publication date: April 17, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Daniel B. Thompson, Jacob J. Richardson, Ingrid Koslow, Jun Seok Ha, Frederick F. Lange, Steven P. DenBaars, Shuji Nakamura
  • Publication number: 20140083352
    Abstract: A method for synthesizing ZnO, comprising continuously circulating a growth solution that is saturated with ZnO between a warmer deposition zone, which contains a substrate or seed, and a cooler dissolution zone, which is contains ZnO source material.
    Type: Application
    Filed: November 27, 2013
    Publication date: March 27, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jacob J. Richardson, Frederick F. Lange
  • Publication number: 20130328012
    Abstract: A method of fabricating a Light Emitting Diode with improved light extraction efficiency, comprising depositing a plurality of Zinc Oxide (ZnO) nanorods on one or more surfaces of a III-Nitride based LED, by growing the ZnO nanorods from an aqueous solution, wherein the surfaces are different from c-plane surfaces of III-Nitride and transmit light generated by the LED.
    Type: Application
    Filed: August 19, 2013
    Publication date: December 12, 2013
    Applicant: The Regents of the University of California
    Inventors: Jacob J. Richardson, Daniel B. Thompson, Ingrid Koslow, Jun-Seok Ha, Frederick F. Lange, Steven P. DenBaars, Shuji Nakamura
  • Publication number: 20110266551
    Abstract: A high brightness III-Nitride based Light Emitting Diode (LED), comprising multiple surfaces covered by Zinc Oxide (ZnO) layers, wherein the ZnO layers are grown in a low temperature aqueous solution and each have a (0001) c-orientation and a top surface that is a (0001) plane.
    Type: Application
    Filed: November 3, 2010
    Publication date: November 3, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Daniel B. Thompson, Jacob J. Richardson, Ingrid Koslow, Jun Seok Ha, Frederick F. Lange, Steven P. DenBaars, Shuji Nakamura, Maryann E. Lange
  • Publication number: 20110108873
    Abstract: A method of fabricating a Light Emitting Diode with improved light extraction efficiency, comprising depositing a plurality of Zinc Oxide (ZnO) nanorods on one or more surfaces of a III-Nitride based LED, by growing the ZnO nanorods from an aqueous solution, wherein the surfaces are different from c-plane surfaces of III-Nitride and transmit light generated by the LED.
    Type: Application
    Filed: November 3, 2010
    Publication date: May 12, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jacob J. Richardson, Daniel B. Thompson, Ingrid Koslow, Jun Seok Ha, Frederick F. Lange, Steven P. DenBaars, Shuji Nakamura
  • Publication number: 20110101414
    Abstract: A method for fabricating a Light Emitting Diode (LED) with increased light extraction efficiency, comprising providing a III-Nitride based LED structure comprising a light emitting active layer between a p-type layer and an n-type layer; growing a Zinc Oxide (ZnO) layer epitaxially on the p-type layer by submerging a surface of the p-type layer in a low temperature aqueous solution, wherein the ZnO layer is a transparent current spreading layer; and depositing a p-type contact on the ZnO layer. The increase in efficiency may be more than 93% with very little or no increase in cost.
    Type: Application
    Filed: November 3, 2010
    Publication date: May 5, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Daniel B. Thompson, Jacob J. Richardson, Steven P. DenBaars, Frederick F. Lange, MaryAnn E. Lange, Jin Hyeok Kim
  • Publication number: 20100263586
    Abstract: A method for synthesizing ZnO, comprising continuously circulating a growth solution that is saturated with ZnO between a warmer deposition zone, which contains a substrate or seed, and a cooler dissolution zone, which is contains ZnO source material.
    Type: Application
    Filed: April 15, 2010
    Publication date: October 21, 2010
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jacob J. Richardson, Frederick F. Lange, Maryann E. Lange
  • Publication number: 20100173213
    Abstract: The present invention concerns improved configurations for a fuel cell army. The contacts for the positive electrode and the negative electrode are made outside the higher temperature active reaction space in a cooler area. Thus different more common materials are used which have a longer lifetime and have less stresses at their lower operating temperature. The invention utilizes tubular cell components connected with spines for efficient electron transfer and at least two manifolds outside the reaction zone, which may be cooled by external means. The external protruding connectors are thus at a lower operating temperature. This invention improves fuel cell life span, provides for lower cost, use of more common materials, and reduces the number thermal defects during operation.
    Type: Application
    Filed: June 30, 2006
    Publication date: July 8, 2010
    Applicant: The Regents of the University of California
    Inventors: Frederick F. Lange, Anil V. Virkar
  • Publication number: 20090175830
    Abstract: The present invention involves compositions and methods for treating cancer using a mutant adenovirus comprising a polynucleotide encoding a therapeutic polypeptide that is targeted to cells with a mutant retinoblastoma pathway. The mutant adenovirus is able to kill the tumor cells without harming cells with a wild type retinoblastoma pathway.
    Type: Application
    Filed: February 12, 2009
    Publication date: July 9, 2009
    Inventors: Juan Fueyo, Candelaria Gomez-Manzano, W.K. Alfred Yung, Charles A. Conrad, Frederick F. Lang, JR.
  • Patent number: 6878466
    Abstract: Reliable, flaw-tolerant brittle materials are produced by incorporating layers under residual compression on the surface and throughout the bulk of the material that act to trap and contain the propagation of otherwise catastrophic cracking. The residual compression within these layers acts to reduce the stress intensity of the cracks, thereby causing them to arrest until further loading is provided. This highly desirable stable, subcritical crack growth mode persists with increased loading until the applied stress is large enough to drive the crack completely through compressive region, after which failure occurs. The exact level of stress needed to accomplish this is dictated by the architectural design of the compressive layers such that the material can be designed to have any minimum strength desired, within the limits of the materials system used. This results in a truncation of the strength distribution, such that there is virtually zero probability of failure below this minimum value, i.e.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: April 12, 2005
    Assignee: The Regents of the University of California
    Inventors: Frederick F. Lange, Masa P. Rao, Antonio Javier Sanchez Herencia
  • Patent number: 6787080
    Abstract: Colloidal isopressing provides a rapid method to form an engineering shape from a powder slurry, previously filtered to remove strength degrading inclusions. A slurry composed of a weakly attractive particle network, produced with a short-range, repulsive interparticle par potential, is consolidated to make a body with a high particle density that is easily fluidized by vibration. The fluid-like body is injected into a flexible mold and subjected to a larger isostatic pressure to force particles into contact. This creates a strong, elastic body with the shape of the mold. Because the particles are forced into contact at a high pressure, the liquid remaining within the component can be removed by evaporation without shrinkage, avoiding fracture during rapid drying.
    Type: Grant
    Filed: July 19, 2002
    Date of Patent: September 7, 2004
    Inventors: Frederick F. Lange, Benjamin C. Yu
  • Patent number: 6770131
    Abstract: A process for producing crystalline III-V compound films, preferably thin films of gallium nitride and other III-V nitrides, on various single crystal substrates. The process enables the preparation of III-V compound films by the simple, direct deposition of an amorphous layer of a III-V compound precursor on a single crystal substrate (as a template). A chemical reaction followed by a single heat treatment leads to the crystallization and formation of films by pyrolysis. According to specific examples of the invention, the chemical precursors gallium dimethyl amide (Ga2[N(CH3)2]6), gallium nitrate (Ga(NO3)3, and gallium isopropoxide [Ga(OC3H7)3 are used to produce gallium nitride thin films.
    Type: Grant
    Filed: November 20, 2001
    Date of Patent: August 3, 2004
    Assignee: The Regents of the University of California
    Inventors: Frederick F. Lange, David Kisailus
  • Publication number: 20030138405
    Abstract: The present invention involves a method of treating cancer using a mutant adenovirus that is targeted to cells with a mutant retinoblastoma pathway. The mutant adenovirus is able to kill the tumor cells without harming the cells with a wild type retinoblastoma pathway.
    Type: Application
    Filed: April 17, 2002
    Publication date: July 24, 2003
    Inventors: Juan Fueyo, Athanassios P. Kyritsis, Candelaria Gomez-Manzano, W.K. Alfred Yung, Polly S.Y. Lee, Victor A. Levin, Charles A. Conrad, Frederick F. Lang
  • Publication number: 20030012874
    Abstract: A process for producing crystalline III-V compound films, preferably thin films of gallium nitride and other III-V nitrides, on various single crystal substrates. The process enables the preparation of III-V compound films by the simple, direct deposition of an amorphous layer of a III-V compound precursor on a single crystal substrate (as a template). A chemical reaction followed by a single heat treatment leads to the crystallization and formation of films by pyrolysis. According to specific examples of the invention, the chemical precursors gallium dimethyl amide (Ga2[N(CH3)2]6), gallium nitrate (Ga(NO3)3, and gallium isopropoxide [Ga(OC3H7)3 are used to produce gallium nitride thin films.
    Type: Application
    Filed: November 20, 2001
    Publication date: January 16, 2003
    Inventors: Frederick F. Lange, David Kisailus