Patents by Inventor Frederick Hughson

Frederick Hughson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystals of LuxP and complexes thereof
    Publication number: 20070185314
    Abstract: A crystal comprising LuxP is obtained, and a binding site for autoinducer-2 (AI-2) identified. The X-ray crystallographic data for LuxP and a LuxP-AI-2 complex is determined and used in a drug discovery method. Pharmaceutical compositions comprising ligands identified by such drug discovery methods are used to treat bacterial infections.
    Type: Application
    Filed: February 28, 2007
    Publication date: August 9, 2007
    Inventors: Bonnie Bassler, Stephan Schauder, Xin Chen, Frederick Hughson, Stephen Cooper
  • AI-2 compounds and analogs based on Salmonella typhimurium LsrB structure
    Publication number: 20060229259
    Abstract: This invention relates to crystals comprising apo-LsrB and holo-LsrB. The structure of holo-LsrB identifies a tetrahydroxytetrahydrofuran derived from 4,5-dihydroxy-2,3-pentanedione (DPD) as the active autoinducer-2 (AI-2) molecule in Salmonella typhimurium. The X-ray crystallographic data can be used in a drug discovery method. Additionally the invention provides AI-2 analogs based on this discovery as well as pharmaceutical compositions containing those analogs.
    Type: Application
    Filed: April 12, 2005
    Publication date: October 12, 2006
    Inventors: Stephen Miller, Karina Xavier, Mlchiko Taga, Shawn Campagna, Martin Semmelhack, Bonnie Bassler, Frederick Hughson
  • AI-2 compounds and analogs based on salmonella typhimurium LsrB structure
    Publication number: 20060063721
    Abstract: This invention relates to crystals comprising apo-LsrB and holo-LsrB. The structure of holo-LsrB identifies a tetrahydroxytetrahydrofuran derived from 4,5-dihydroxy-2,3-pentanedione (DPD) as the active autoinducer-2 (AI-2) molecule in Salmonella typhimurium. The X-ray crystallographic data can be used in a drug discovery method. Additionally the invention provides AI-2 analogs based on this discovery as well as pharmaceutical compositions containing those analogs.
    Type: Application
    Filed: September 16, 2005
    Publication date: March 23, 2006
    Inventors: Stephen Miller, Karina Xavier, Michiko Taga, Shawn Campagna, Martin Semmelhack, Bonnie Bassler, Frederick Hughson