Patents by Inventor Frederick J. Antosz

Frederick J. Antosz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystal form
    Patent number: 7112670
    Abstract: The present invention involves a novel crystal form of 17?-hydroxy-7?-(5?-methyl-2?-furyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid, ?-lactone, having the formula which is an intermediate useful in preparation of an important pharmaceutical, eplerenone.
    Type: Grant
    Filed: September 19, 2003
    Date of Patent: September 26, 2006
    Assignee: Pharmacia Corporation
    Inventors: Bruce Allen Pearlman, Frederick J. Antosz
  • Novel crystal form
    Publication number: 20040127702
    Abstract: The present invention involves a novel crystal form of 17&bgr;-hydroxy-7&agr;-(5′-methyl-2′-furyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid, &ggr;-lactone, having the formula 1
    Type: Application
    Filed: September 19, 2003
    Publication date: July 1, 2004
    Inventors: Bruce Allen Pearlman, Frederick J. Antosz
  • Process for preparing 9.alpha.-OH BN alcohol
    Patent number: 4226936
    Abstract: Valuable steroid intermediates, 9.alpha.-hydroxyandrost-4-ene-17.beta.-ol-3-one (9.alpha.-OH testosterone), 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-ol (9.alpha.-OH BN alcohol) and 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-oic methyl ester (9.alpha.-OH BN acid methyl ester), prepared by microbiological conversion of steroids having 17-alkyl side chains of 8 to 10 carbons.
    Type: Grant
    Filed: April 23, 1979
    Date of Patent: October 7, 1980
    Assignee: The Upjohn Company
    Inventors: Merle G. Wovcha, Frederick J. Antosz, John M. Beaton, Alfred B. Garcia, Leo A. Kominek
  • Process for preparing 9.alpha.-OH BN acid methyl ester
    Patent number: 4223092
    Abstract: Valuable steroid intermediates, 9.alpha.-hydroxyandrost-4-ene-17.beta.-ol-3-one (9.alpha.-OH testosterone), 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-ol (9.alpha.-OH BN alcohol) and 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-oic methyl ester (9.alpha.-OH BN acid methyl ester), prepared by microbiological conversion of steroids having 17-alkyl side chains of 8 to 10 carbons.
    Type: Grant
    Filed: April 23, 1979
    Date of Patent: September 16, 1980
    Assignee: The Upjohn Company
    Inventors: Merle G. Wovcha, Frederick J. Antosz, John M. Beaton, Alfred B. Garcia, Leo A. Kominek
  • Process for preparing 9.alpha.-OH testosterone
    Patent number: 4221868
    Abstract: Valuable steroid intermediates, 9.alpha.-hydroxyandrost-4-ene-17.beta.-ol-3-one (9.alpha.-OH testosterone), 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-ol (9.alpha.-OH BN alcohol) and 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-oic methyl ester (9.alpha.-OH BN acid methyl ester), prepared by microbiological conversion of steroids having 17-alkyl side chains of 8 to 10 carbons.
    Type: Grant
    Filed: April 23, 1979
    Date of Patent: September 9, 1980
    Assignee: The Upjohn Company
    Inventors: Merle G. Wovcha, Frederick J. Antosz, John M. Beaton, Alfred B. Garcia, Leo A. Kominek
  • Process for preparing 9.alpha.-OH BN alcohol
    Patent number: 4214052
    Abstract: Valuable steroid intermediates, 9.alpha.-hydroxyandrost-4-ene-17.beta.-ol-3-one (9.alpha.-OH testosterone), 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-ol (9.alpha.-OH BN alcohol) and 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-oic methyl ester (9.alpha.-OH BN acid methyl ester), prepared by microbiological conversion of steroids having 17-alkyl side chains of 8 to 10 carbons.
    Type: Grant
    Filed: April 23, 1979
    Date of Patent: July 22, 1980
    Assignee: The Upjohn Company
    Inventors: Merle G. Wovcha, Frederick J. Antosz, John M. Beaton, Alfred B. Garcia, Leo A. Kominek
  • Process for preparing 9.alpha.-OH BN acid methyl ester
    Patent number: 4214051
    Abstract: Valuable steroid intermediates, 9.alpha.-hydroxyandrost-4-ene-17.beta.-ol-3-one (9.alpha.-OH testosterone), 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-ol (9.alpha.-OH BN alcohol) and 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-oic methyl ester (9.alpha.-OH BN acid methyl ester), prepared by microbiological conversion of steroids having 17-alkyl side chains of 8 to 10 carbons.
    Type: Grant
    Filed: April 23, 1979
    Date of Patent: July 22, 1980
    Assignee: The Upjohn Company
    Inventors: Merle G. Wovcha, Frederick J. Antosz, John M. Beaton, Alfred B. Garcia, Leo A. Kominek
  • Composition of matter and process
    Patent number: 4175006
    Abstract: Valuable steroid intermediates, 9.alpha.-hydroxyandrost-4-ene-17.beta.-ol-3-one (9.alpha.--OH testosterone), 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-ol (9.alpha.--OH BN alcohol) and 9.alpha.---hydroxy-3-ketobisnorchol-4-en-22-oic methyl ester (9.alpha.--OH BN acid methyl ester), prepared by microbiological conversion of steroids having 17-alkyl side chains of 8 to 10 carbons.
    Type: Grant
    Filed: October 21, 1977
    Date of Patent: November 20, 1979
    Assignee: The Upjohn Company
    Inventors: Merle G. Wovcha, Frederick J. Antosz, John M. Beaton, Alfred B. Garcia, Leo A. Kominek
  • Derivatives of streptovaricin ansamycins
    Patent number: 4076725
    Abstract: New biologically active compounds derived by acylation and/or oxidative degradation of streptovaricin ansamycin materials, pharmaceutical compositions and therapeutic methods involving the same.
    Type: Grant
    Filed: January 6, 1976
    Date of Patent: February 28, 1978
    Assignee: University of Illinois Foundation
    Inventors: Kenneth L. Rinehart, Jr., Frederick J. Antosz, Kazuya Sasaki
  • 9.alpha.-Hydroxy-bis-nor-cholanic acid
    Patent number: 4062880
    Abstract: The novel compound 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-oic, hereinafter referred to as 9.alpha.-OH BN acid. This compound is producible in a fermentation using the microorganism Mycobacterium fortuitum, NRRL B-8119. 9.alpha.-OH BN acid can be used as an intermediate to make useful steroids.
    Type: Grant
    Filed: January 21, 1977
    Date of Patent: December 13, 1977
    Assignee: The Upjohn Company
    Inventors: Frederick J. Antosz, Willard J. Haak, Merle G. Wovcha
  • Process of producing 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-oic with mycobacterium fortuitum
    Patent number: 4029549
    Abstract: The novel compound 9.alpha.-hydroxy-3-ketobisnorchol-4-en-22-oic, hereinafter referred to as 9.alpha.-OH BN acid. This compound is producible in a fermentation using the microorganism Mycobacterium fortuitum, NRRL B-8119. 9.alpha.-OH BN acid can be used as an intermediate to make useful steroids.
    Type: Grant
    Filed: April 30, 1976
    Date of Patent: June 14, 1977
    Assignee: The Upjohn Company
    Inventors: Frederick J. Antosz, Willard J. Haak, Merle G. Wovcha