Patents by Inventor Frederick J. Brown

Frederick J. Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6359038
    Abstract: Arc-quenching fuse tubes comprising an elongated tubular body having an inner arc-quenching surface layer which comprises an arc-quenching matrix comprising a fibrous material and an arc-quenching composition. The arc-quenching compositions comprise a cured composition of an aromatic epoxy resin and a linear aliphatic epoxy resin.
    Type: Grant
    Filed: September 22, 1999
    Date of Patent: March 19, 2002
    Assignee: ABB Power T&D Company Inc.
    Inventors: Frederick J. Brown, Allan G. Loosemore, Ian J. Harvey, Brent A. Sievers
  • Patent number: 5975145
    Abstract: Arc-quenching fuse tubes comprising an elongated tubular body having an inner arc-quenching surface layer which comprises an arc-quenching matrix comprising a fibrous material and an arc-quenching composition. The arc-quenching compositions comprise a cured composition of an aromatic epoxy resin and a linear aliphatic epoxy resin.
    Type: Grant
    Filed: May 21, 1996
    Date of Patent: November 2, 1999
    Assignee: ABB Power T&D Company Inc.
    Inventors: Frederick J. Brown, Allan G. Loosemore, Ian J. Harvey, Brent A. Sievers
  • Patent number: 5583152
    Abstract: The invention concerns novel, pharmaceutically useful, amide derivatives of certain benzoheterocyclylalkanoic acids (and related tetrazoles and acylsulphonamides) of the formula I and salts thereof, wherein the radicals R.sup.1, R.sup.2, L, X, Y, Z, A.sup.1, Q, A.sup.2 and M have the meanings set out in the specification. The invention also includes pharmaceutical compositions incorporating a formula I compound or a salt thereof, a process for the manufacture of the said compound, together with intermediates for use in the latter process.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: December 10, 1996
    Assignee: Zeneca Inc.
    Inventors: Peter R. Bernstein, Frederick J. Brown, Victor G. Matassa, Ying K. Yee
  • Patent number: 5486515
    Abstract: Compounds of formula I ##STR1## wherein X.sup.a, X.sup.b, R, R.sup.1 and R.sup.2 have any of the meanings given in the specification, and their pharmaceutically acceptable salts are useful as potassium channel openers for the treatment of urinary incontinence. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
    Type: Grant
    Filed: May 9, 1994
    Date of Patent: January 23, 1996
    Assignee: Zeneca Limited
    Inventors: Frederick J. Brown, Keith Russell, Paul J. Warwick, Jr.
  • Patent number: 5440035
    Abstract: The invention concerns novel, pharmaceutically useful, amide derivatives of certain benzoheterocyclylalkanoic acids (and related tetrazoles and acylsulphonamides) of the formula I and salts thereof, wherein the radicals R.sup.1, R.sup.2, L, X, Y, Z, A.sup.1, Q, A.sup.2 and M have the meanings set out in the specification. The invention also includes pharmaceutical compositions incorporating a formula I compound or a salt thereof, a process for the manufacture of the said compound, together with intermediates for use in the latter process.
    Type: Grant
    Filed: October 25, 1994
    Date of Patent: August 8, 1995
    Assignee: Zeneca Inc.
    Inventors: Peter R. Bernstein, Frederick J. Brown, Victor G. Matassa, Ying K. Yee
  • Patent number: 5391758
    Abstract: The invention concerns novel, pharmaceutically useful, amide derivatives of certain benzoheterocyclylalkanoic acids (and related tetrazoles and acylsulphonamides) of the formula I and salts thereof, wherein the radicals R.sup.1, R.sup.2, L, X, Y, Z, A.sup.1, Q, A.sup.2 and M have the meanings set out in the specification. The invention also includes pharmaceutical compositions incorporating a formula I compound or a salt thereof, a process for the manufacture of the said compound, together with intermediates for use in the latter process.
    Type: Grant
    Filed: June 6, 1994
    Date of Patent: February 21, 1995
    Assignee: Zeneca, Inc.
    Inventors: Peter R. Bernstein, Frederick J. Brown, Victor G. Matassa, Ying K. Yee
  • Patent number: 5338734
    Abstract: The invention concerns novel, pharmaceutically useful, amide derivatives of certain benzoheterocyclylalkanoic acids (and related tetrazoles and acylsulphonamides) of the formula I and salts thereof, wherein the radicals R.sup.1, R.sup.2, L, X, Y, Z, A.sup.1, Q, A.sup.2 and M have the meanings set out in the specification. The invention also includes pharmaceutical compositions incorporating a formula I compound or a salt thereof, a process for the manufacture of the said compound, together with intermediates for use in the latter process.
    Type: Grant
    Filed: November 25, 1992
    Date of Patent: August 16, 1994
    Assignee: Zeneca Inc.
    Inventors: Peter R. Bernstein, Frederick J. Brown, Victor G. Matassa, Ying K. Yee
  • Patent number: 5234942
    Abstract: The invention provides a series of novel heterocyclic amides of the formula I in which the group A; CRa can be --CRb.dbd.CRa--, --CHRb--CHRa-- or --N.dbd.CRa--, the amidic group Re.L can be Rd.X.CO.NH, Re.X.CS.NH or Re.NH.CO attached to position 4, 5 or 6 of the benzenoid moiety, z is an acid group selected from the group consisting of carboxy, an acylsulphonamide residue of the formula CO.NH.SO.sub.n Rg and a tetrazolyl residue of the formula II and the radicals Ra, Rb, Rc, Rd, Re, Rf, Rg, Rh, n, X, G.sup.1,Q and G.sup.2 have the meanings defined in the following specification.The compounds of formula I are leukotriene antagonists.
    Type: Grant
    Filed: December 17, 1990
    Date of Patent: August 10, 1993
    Assignee: ICI Americas Inc.
    Inventors: Peter R. Bernstein, Frederick J. Brown, Ying K. Yee
  • Patent number: 5179112
    Abstract: The invention concerns novel, pharmaceutically useful, amide derivatives of certain benzoheterocyclylalkanoic acids (and related tetrazoles and acylsulphonamides) of the formula I and salts thereof, wherein the radicals R.sup.1, R.sup.2, L, X, Y, Z, A.sup.1, Q, A.sup.2 and M have the meanings set out in the specification. The invention also includes pharmaceutical compositions incorporating a formula I compound or a salt thereof, a process for the manufacture of the said compound, together with intermediates for use in the latter process.
    Type: Grant
    Filed: June 6, 1991
    Date of Patent: January 12, 1993
    Assignee: ICI Americas Inc.
    Inventors: Peter R. Bernstein, Frederick J. Brown, Victor G. Matassa, Ying K. Yee
  • Patent number: 5095038
    Abstract: This invention comprises novel carbocyclic compounds of formula I (wherein A, Z, R.sup.11 and R.sup.12 are defined in the specification) derived from acylsulfonamide derivatives of .alpha.-carbocyclyltoluic acids wherein said compounds of formula I antagonize the actions of one or more of the arachidonic acid metabolites known as leukotrienes. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.
    Type: Grant
    Filed: April 12, 1989
    Date of Patent: March 10, 1992
    Assignee: ICI Americas Inc.
    Inventors: Frederick J. Brown, Thomas P. Maduskuie, Jr., Victor G. Matassa, Ying K. Yee
  • Patent number: 5049576
    Abstract: This invention provides a series of novel heterocyclic amides of formula I in which the group >X--Y--Z< is selected from >C.dbd.CH--N<, >C.dbd.N--N<, >N--(CH.sub.2)--N<, >CH--CH.sub.2 --N< and >N--N.dbd.C< and the other radicals have the meanings defined in the following specification.The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compounds, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.
    Type: Grant
    Filed: December 29, 1989
    Date of Patent: September 17, 1991
    Assignee: ICI Americas Inc.
    Inventors: Peter R. Bernstein, Frederick J. Brown, Victor G. Matassa, Ying K. Yee
  • Patent number: 5030643
    Abstract: The invention concerns novel, pharmaceutically useful, amide derivatives of certain benzoheterocyclylalkanoic acids (and related tetrazoles and acylsulphonamides) of the formula I and salts thereof, wherein the radicals R.sup.1, R.sup.2, L, X, Y, Z, A.sup.1, Q, A.sup.2 and M have the meanings set out in the specification. The invention also includes pharmaceutical compositions incorporating a formula I compound or a salt thereof, a process for the manufacture of the said compound, together with intermediates for use in the latter process.
    Type: Grant
    Filed: July 14, 1989
    Date of Patent: July 9, 1991
    Assignee: ICI Americas Inc.
    Inventors: Peter R. Bernstein, Frederick J. Brown, Victor G. Matassa, Ying Kwong Yee
  • Patent number: 4997844
    Abstract: The invention provides a series of novel heterocyclic amides of the formula I in which the group A CRa can be --CRb.dbd.CRa--, --CHRb--CHRa-- or --N.dbd.CRa--, the amidic group Re.L can be Re.X.CO.NH, Re.X.CS.NH or Re.NH.CO attached at position 4, 5 or 6 of the benzenoid moiety, Z is an acid group selected from the group consisting of carboxy, an acylsulphonamide residue of the formula CO.NH.SO.sub.n Rg and a tetrazolyl residue of the formula II, and the radicals Ra, Rb, Rc, Rd, Re, Rf, Rg, Rh, n, X, G.sup.1, Q and G.sup.2 have the meanings defined in the following specification.The compounds of formula I are leukotriene antagonists.
    Type: Grant
    Filed: October 18, 1985
    Date of Patent: March 5, 1991
    Assignee: ICI Americas Inc.
    Inventors: Peter R. Bernstein, Frederick J. Brown, Ying K. Yee
  • Patent number: 4945333
    Abstract: A fuse assembly for an electrical cutout is provided with capability for rapid arc extinction by a capsule of pressurized insulating gas being located within a fuse tube above the fusible element so that when the fusible element melts and an arc is produced, gas is released from the gas cylinder that quenches and cools the arc and also assists a spring loaded flipper mechanism in expelling a lower conductor from the fuse tube.
    Type: Grant
    Filed: February 13, 1989
    Date of Patent: July 31, 1990
    Assignee: Asea Brown Boveri Inc.
    Inventors: Nicholas J. Stroud, Andrew S. Sweetana, Jr., Frederick J. Brown, Thomas P. Basa
  • Patent number: 4918094
    Abstract: This invention provides a series of novel heterocyclic amides of formula I in which the group >X-Y-Z< is selected from >C.dbd.CH--N<, >C.dbd.N--N<, >N--(CH.sub.2)--N<, >CH--CH.sub.2 --N< and >N--N.dbd.C< and the other radicals have the meanings defined in the following specification.The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the formula I compounds: pharmaceutical compositions containing the formula I compounds, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.
    Type: Grant
    Filed: October 16, 1986
    Date of Patent: April 17, 1990
    Assignee: ICI Americas Inc.
    Inventors: Peter R. Bernstein, Frederick J. Brown, Victor G. Matassa, Ying K. Yee
  • Patent number: 4898863
    Abstract: This invention provides a series of novel heterocyclic carboxamides of formula I in which the group --Y--Z< is selected from --C(Ra).dbd.C<, --N.dbd.C<, and --CH(Ra)--CH< and the other radicals have the meanings defined in the following specification.The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseasxes, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.
    Type: Grant
    Filed: April 15, 1987
    Date of Patent: February 6, 1990
    Assignee: ICI Americas Inc.
    Inventors: Frederick J. Brown, Ying K. Yee
  • Patent number: 4894386
    Abstract: This invention provides a series of novel heterocyclic aliphatic carboxamides of formula I in which the group >Z--Y--X< is selected from >C.dbd.CH--N<, >N--CH.dbd.C<, >C.dbd.N--N< and >N--N.dbd.C< and the other radicals have the meanings defined in the following specification. The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.
    Type: Grant
    Filed: October 11, 1988
    Date of Patent: January 16, 1990
    Assignee: ICI Americas Inc.
    Inventors: Frederick J. Brown, Victor G. Matassa
  • Patent number: 4859692
    Abstract: The invention concerns novel, pharmaceutically useful, amide derivatives of certain benzoheterocyclylalkanoic acids (and related tetrazoles and acylsulphonamides) of the formula I and salts thereof, wherein the radicals R.sup.1, R.sup.2, L, X, Y, Z, A.sup.1, Q, A.sup.2 and M have the meanings set out in the specification. The invention also includes pharmaceutical compositions incorporating a formula I compound or a salt thereof, a process for the manufacture of the said compound, together with intermediates for use in the latter process.
    Type: Grant
    Filed: April 16, 1986
    Date of Patent: August 22, 1989
    Assignee: ICI Americas Inc.
    Inventors: Peter R. Bernstein, Frederick J. Brown, Victor G. Matassa, Ying Kwong Yee
  • Patent number: 4837235
    Abstract: This invention provides a series of novel keto sulfones of formula I ##STR1## in which the group .dbd.A-- is selected from .dbd.C(Ra)-- and .dbd.N-- and the other radicals have the meanings defined in the following specification.The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.
    Type: Grant
    Filed: October 16, 1986
    Date of Patent: June 6, 1989
    Assignee: ICI Americas Inc.
    Inventors: Peter R. Bernstein, Frederick J. Brown, Victor G. Matassa, Ying K. Yee
  • Patent number: 4477792
    Abstract: The present invention discloses a modular reactor that increases the inductance per axial length by winding a conductor circumferentially about a central axis in a manner which results in radially extending columns which are sequentially wound in alternating radial order. The modules are constructed to allow them to be combined in either radial or axial juxtaposition and electrically connected either in series or in parallel.
    Type: Grant
    Filed: January 29, 1982
    Date of Patent: October 16, 1984
    Assignee: Westinghouse Electric Corp.
    Inventors: Thomas H. Putman, Andrew S. Sweetana, Jr., Frederick J. Brown