Patents by Inventor Frederick J. Monsma, Jr.

Frederick J. Monsma, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • St-B17 serotonin receptor
    Patent number: 6844190
    Abstract: Genes encoding the St-B17 serotonin receptor protein were cloned and characterized from a rat striatum mRNA and a human genomic library. The St-B17 receptor has nucleotide and amino acid homology with previously described 5-HT genes and can bind ligands that are known to interact with serotonin receptors. In addition, the levels of intracellular cAMP in cells transfected with the receptor gene respond in a dose dependent manner to introduction of serotonin in the media.
    Type: Grant
    Filed: April 10, 2001
    Date of Patent: January 18, 2005
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: David R. Sibley, Frederick J. Monsma, Jr., Mark Hamblin
  • PCT-65 serotonin receptor
    Patent number: 5914236
    Abstract: The PCT-65 serotonin receptor gene was cloned and characterized from rat and human libraries. This receptor has nucleotide and amino acid homology with previously described 5-HT genes and can bind ligands that are known to interact with serotonin receptors.
    Type: Grant
    Filed: September 18, 1995
    Date of Patent: June 22, 1999
    Assignee: United States of America
    Inventors: Frederick J. Monsma, Jr., Yong Shen, David R. Sibley, Mark Hamblin
  • cDNA encoding the long isoform of the D.sub.2 dopamine receptor
    Patent number: 5552289
    Abstract: In the present investigation, we report the identification and cloning of a cDNA encoding an RNA splice variant of the rat D.sub.2 receptor CDNA.sup.12. This cDNA codes for a receptor isoform which is predominantly expressed in the brain and contains an additional 29 amino acids in the 3rd cytoplasmic loop, a region believed to be involved with G protein coupling. This is the first example of a novel G-protein coupled receptor isoform generated by alternative RNA splicing.
    Type: Grant
    Filed: August 3, 1993
    Date of Patent: September 3, 1996
    Assignee: United States of America
    Inventors: David R. Sibley, Frederick J. Monsma, Jr., Loris D. McVittie, Lawrence C. Mahan
  • cDNA encoding the long isoform of the D.sub.2 dopamine receptor
    Patent number: 5128254
    Abstract: In the present investigation, we report the identification and cloning of a cDNA encoding an RNA splice variant of the rat D.sub.2 receptor cDNA.sup.12. This cDNA codes for a receptor isoform which is predominantly expressed in the brain and contains an additional 29 amino acids in the 3rd cytoplasmic loop, a region believed to be involved with G protein coupling. This is the first example of a novel G-protein coupled receptor isoform generated by alternative RNA splicing.
    Type: Grant
    Filed: November 1, 1989
    Date of Patent: July 7, 1992
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: David R. Sibley, Frederick J. Monsma, Jr., Loris D. McVittie, Lawrence C. Mahan