Patents by Inventor Frederick James Monsma, Jr.

Frederick James Monsma, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-PCSK9 and methods for treating lipid and cholesterol disorders
    Patent number: 8598320
    Abstract: The present invention provides compositions and methods for treating disorders of cholesterol and lipid metabolism by administration of an anti-PCSK9 antibody or a peptide inhibitor of PCSK9.
    Type: Grant
    Filed: October 27, 2008
    Date of Patent: December 3, 2013
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Joseph A. Hedrick, Frederick James Monsma, Jr., Tatyana Churakova, Diane Hollenbaugh
  • ANTI-PCSK9 AND METHODS FOR TREATING LIPID AND CHOLESTEROL DISORDERS
    Publication number: 20110033465
    Abstract: The present invention provides compositions and methods for treating disorders of cholesterol and lipid metabolism by administration of an anti-PCSK9 antibody or a peptide inhibitor of PCSK9.
    Type: Application
    Filed: October 27, 2008
    Publication date: February 10, 2011
    Applicant: SCHERING CORPORATION
    Inventors: Joseph A. Hedrick, Frederick James Monsma, JR., Tatyana Churakova, Diane Hollenbaugh
  • Modulators of the orphan G protein-coupled receptors GPR78 and GPR26
    Patent number: 7872101
    Abstract: The invention relates to the use of the interaction between the GPR78 polypeptide or the GPR26 polypeptide and their identified ligands and antagonists as the basis for screening methods for the identification of agents that modulate the activity of these receptors, and for diagnostic and therapeutic purposes. The agents identified by the screening methods of the invention have use in the treatment of GPR78- and/or GPR26-mediated disorders, including, but not limited to, neurological disorders (such as anxiety disorders), metabolic disorders, cardiovascular disorders, hormone-related disorders, vascular disorders and hyperproliferative disorders (such as cancer).
    Type: Grant
    Filed: December 3, 2007
    Date of Patent: January 18, 2011
    Assignee: Schering Corporation
    Inventors: Suke Wang, Frederick James Monsma, Jr., Xiaoxin Yang, Eric L. Gustafson, Maureen Laverty, Elizabeth B. Smith
  • Histamine receptor
    Patent number: 7547523
    Abstract: The present invention provides an isolated mammalian histamine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by histamine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian histamine receptor.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: June 16, 2009
    Assignee: Schering Corporation
    Inventors: Jiang X. Behan, Joseph A. Hedrick, Thomas M. Laz, Frederick James Monsma, Jr., Kelley L. Morse, Shelby P. Umland, Suke Wang