Abstract: The present application relates to process record slide and method of using the same for loose cells. A single to multi-region slide wherein each region contains one to four control targets and is suitable for processing through Special Stains, IHC or CC, and others. Each region may be bonded by a hydrophobic barrier to form a well. The slide has an adhesive coating suitable for capturing loose cells and cell debris.

Abstract: The present application relates to process record slide and method of using the same for loose cells. A single to multi-region slide wherein each region contains one to four control targets and is suitable for processing through Special Stains, IHC or CC, and others. Each region may be bonded by a hydrophobic barrier to form a well. The slide has an adhesive coating suitable for capturing loose cells and cell debris.

Abstract: A phase-separated evaporator includes a boiler plate and a phase separation chamber that includes a housing, connected to the boiler plate, having a gas port and a liquid port; and a phase partitioner connected to interiors of the housing, dividing the phase-separated evaporator into a vapor directing compartment and a condensate directing compartment. The phase partitioner includes a partition panel and multiple feeding injectors extending from the partition panel, with the injector tips disposed immediately above the boiler plate. The returning condensate from a condenser enters from the liquid port into the condensate directing compartment and feeds onto the boiler plate through the feeding injectors; while the vapor generated in the vapor directing compartment exits from the gas port, without encountering the condensate.

Abstract: A phase-separated evaporator includes a boiler plate and a phase separation chamber that includes a housing, connected to the boiler plate, having a gas port and a liquid port; and a phase partitioner connected to interiors of the housing, dividing the phase-separated evaporator into a vapor directing compartment and a condensate directing compartment. The phase partitioner includes a partition panel and multiple feeding injectors extending from the partition panel, with the injector tips disposed immediately above the boiler plate. The returning condensate from a condenser enters from the liquid port into the condensate directing compartment and feeds onto the boiler plate through the feeding injectors; while the vapor generated in the vapor directing compartment exits from the gas port, without encountering the condensate.

Abstract: An apparatus and method for determining the density and fluid-type of a fluid flowing in a capillary tube, the velocity and viscosity of a blood sample flowing in a capillary tube, the erythrocyte sedimentation rate (ESR) of a blood sample after flow has been brought to an abrupt stop in a capillary tube, and/or the zeta sedimentation rate (ZSR) of a blood sample after flow has been brought to an abrupt stop in a capillary tube. These measurements are accomplished by directing a waveform pulse, such as an ultrasound pulse, at a pre-determined frequency transversely across the capillary tube and sample fluid, and by determining the flight of time of the pulse through the capillary tube and sample fluid and/or the Doppler shift of the echo signals reflecting off cells moving forwardly or transversely within a flowing, or stationary, blood sample.

Abstract: An apparatus and method for determining the density and fluid-type of a fluid flowing in a capillary tube, the velocity and viscosity of a blood sample flowing in a capillary tube, the erythrocyte sedimentation rate (ESR) of a blood sample after flow has been brought to an abrupt stop in a capillary tube, and/or the zeta sedimentation rate (ZSR) of a blood sample after flow has been brought to an abrupt stop in a capillary tube. These measurements are accomplished by directing a waveform pulse, such as an ultrasound pulse, at a pre-determined frequency transversely across the capillary tube and sample fluid, and by determining the flight of time of the pulse through the capillary tube and sample fluid and/or the Doppler shift of the echo signals reflecting off cells moving forwardly or transversely within a flowing, or stationary, blood sample.

Abstract: A physically compact (saline) solution preparation apparatus includes a solution mixing tank coupled to sources of concentrate and diluent. A concentrate transport path is configured to both homogenize and deliver concentrate to the mixing tank, while the diluent transport path is controllably purged of potential contaminates prior to supplying the diluent to the mixing tank. A mixed solution transport path recirculates and thereby homogenizes the contents of the mixing container, and actively pumps out solution that has been mixed to a prescribed conductivity-based concentration, to one or more solution on demand storage reservoirs for respective instruments. The operation of the apparatus is based upon measured conductivity of the contents of the solution mixing tank, so that there is no need to conduct precursor volumetric measurements of either diluent or concentrate.

Abstract: A physically compact (saline) solution preparation apparatus includes a solution mixing tank coupled to sources of concentrate and diluent. A concentrate transport path is configured to both homogenize and deliver concentrate to the mixing tank, while the diluent transport path is controllably purged of potential contaminates prior to supplying the diluent to the mixing tank. A mixed solution transport path recirculates and thereby homogenizes the contents of the mixing container, and actively pumps out solution that has been mixed to a prescribed conductivity-based concentration, to one or more solution on demand storage reservoirs for respective instruments. The operation of the apparatus is based upon measured conductivity of the contents of the solution mixing tank, so that there is no need to conduct precursor volumetric measurements of either diluent or concentrate.

Abstract: A junction field effect transistor (JFET) RF oscillator-detector circuit generates an RF signal for an apparatus for conducting electrical measurements of particles contained in a carrier fluid passing through an aperture in a cytometer flow cell. The JFET oscillator includes a plurality of parallel-coupled JFETs having respectively different VDS vs. IDS characteristics, that are biased to operate at square law detection regions of their respective VDS vs. IDS characteristics. One JFET operates in Class C mode, while the other operates in Class AB mode. An RF resonant circuit is electrically coupled to the JFETs and to the measurement cell, and is operative to establish the frequency of an RF field applied to the measurement cell. An RF load change detection circuit is coupled to the RF resonator circuit and is operative to detect an RF load change associated with a modification of the RF field as a result of a particle within the measurement cell aperture.

Abstract: A junction field effect transistor (JFET) RF oscillator-detector circuit generates an RF signal for an apparatus for conducting electrical measurements of particles contained in a carrier fluid passing through an aperture in a cytometer flow cell. The JFET oscillator includes a plurality of parallel-coupled JFETs having respectively different VDS vs. IDS characteristics, that are biased to operate at square law detection regions of their respective VDS vs. IDS characteristics. One JFET operates in Class C mode, while the other operates in Class AB mode. An RF resonant circuit is electrically coupled to the JFETs and to the measurement cell, and is operative to establish the frequency of an RF field applied to the measurement cell. An RF load change detection circuit is coupled to the RF resonator circuit and is operative to detect an RF load change associated with a modification of the RF field as a result of a particle within the measurement cell aperture.

Abstract: A junction field effect transistor (JFET) RF oscillator-detector circuit generates an RF signal for an apparatus for conducting electrical measurements of particles contained in a carrier fluid passing through an aperture in a cytometer flow cell. The JFET oscillator includes a plurality of parallel-coupled JFETs having respectively different VDS vs. IDS characteristics, that are biased to operate at square law detection regions of their respective VDS vs. IDS characteristics. One JFET operates in Class C mode, while the other operates in Class AB mode. An RF resonant circuit is electrically coupled to the JFETs and to the measurement cell, and is operative to establish the frequency of an RF field applied to the measurement cell. An RF load change detection circuit is coupled to the RF resonator circuit and is operative to detect an RF load change associated with a modification of the RF field as a result of a particle within the measurement cell aperture.

Abstract: A controller for operating a stepping motor to a resolution defined by plural inter-pole motor positions includes a digital processor for communication with an external host system for controlling operation of the stepping motor, at least in a microstep mode. The processor selects Sine/Cosine driving current values for the motor windings from a table covering at least 90.degree., to define the inter-pole positions, stored in a RAMDAC or combination digital memory and digital to analog converter. The processor also controls scaling of the output of the digital to analog converter for different modes of operation, such as normal, hold and shutdown. The RAMDAC also can be loaded by the processor. Power stages are coupled to two analog outputs of the RAMDAC amplify the RAMDAC output signals, and provide a high power output to the windings using bridge drivers.

Abstract: An apparatus for forming a differential image of a specimen is disclosed. The two images whose difference is used to generate the differential image are made by illuminating said specimen with polarized light, each image corresponding to illuminating the specimen with light of a different polarization. The intensity of the differential image at each point is related to the difference in intensities observed when the point in question is illuminated with light having the different polarizations divided by the sum of said observed intensities. The present invention includes a light source for illuminating the image with polarized light having a polarization which oscillates between first and second preselected states of polarization, said oscillations occurring at a predetermined frequency.

Abstract: An optical switching device selectively couples an optical port of a first type (e.g., an input port, at which a light beam is introduced into the apparatus) to one of at least two optical ports of a second type (e.g. output ports, from which a light beam leaves the apparatus) which are at predetermined, angularly-spaced positions about a central axis of the device. The device comprises an optical imaging device mounted to rotate about the central axis between a first position, in which the port of the first type is optically conjugate with one of the ports of the second type, and a second position, in which the port of the first type is optically conjugate with the other port of the second type.