Abstract: Disclosed are improved methods for the synthesis of N-(8-[2-hydroxybenzoyl]- amino) caprylic acid. Certain compounds have been found useful for preventing the formation of a colored impurity when included in an ester hydrolysis reaction. Conducting ester hydrolysis in anaerobic conditions has also been found to minimize the formation of the color impurity. Also disclosed are improved methods for synthesizing the sodium salt of N-(8-[2-hydroxybenzoyl]-amino) caprylic acid.

Abstract: Disclosed are improved methods for the synthesis of N-(8-[2-hydroxybenzoyl]-amino) caprylic acid. Certain compounds have been found useful for preventing the formation of a colored impurity when included in an ester hydrolysis reaction. Conducting ester hydrolysis in anaerobic conditions has also been found to minimize the formation of the color impurity. Also disclosed are improved methods for synthesizing the sodium salt of N-(8-[2-hydroxybenzoyl]-amino) caprylic acid.

Abstract: Disclosed are improved methods for the synthesis of N-(8-[2-hydroxybenzoyl]-amino) caprylic acid. Certain compounds have been found useful for preventing the formation of a colored impurity when included in an ester hydrolysis reaction. Conducting ester hydrolysis in anaerobic conditions has also been found to minimize the formation of the color impurity. Also disclosed are improved methods for synthesizing the sodium salt of N-(8-[2-hydroxybenzoyl]-amino) caprylic acid.

Abstract: An apparatus includes a foam metal panel heat exchanger core positioned in a duct, an inlet flow passage for directing a first fluid to the heat exchanger core, and an exit flow passage for directing the first fluid from the heat exchanger core, wherein the inlet flow passage is tapered relative to an inlet face of the heat exchanger core and the exit flow passage is tapered relative to an outlet face of the heat exchanger core. The first fluid has a substantially uniform flow distribution through the core. The inlet and exit flow passages can be adjacent to each other. The core can be formed of a compressed foam.

Abstract: A disruptive media dispersal system for aircraft which absorbs and scatters directed energy weapon beams such as tracking lasers and high energy lasers (HELs) is disclosed. The system may include laser detectors, laser beam propagation disruptive media and a dispersal system. When attacked by a directed energy weapon such as a laser, the laser detector system or vehicle operator deploys the disruptive media. The disruptive media is released by a feeder and dispersal system into the air in the path of the tracking and/or HEL weapon. For example, the dispersal system may be located onboard the aircraft near the front of the fuselage.

Abstract: An apparatus includes a foam metal panel heat exchanger core positioned in a duct, an inlet flow passage for directing a first fluid to the heat exchanger core, and an exit flow passage for directing the first fluid from the heat exchanger core, wherein the inlet flow passage is tapered relative to an inlet face of the heat exchanger core and the exit flow passage is tapered relative to an outlet face of the heat exchanger core. The first fluid has a substantially uniform flow distribution through the core. The inlet and exit flow passages can be adjacent to each other. The core can be formed of a compressed foam.

Abstract: Disclosed are improved methods for the synthesis of N-(8-[2-hydroxybenzoyl]-amino)caprylic acid. Certain compounds have been found useful for preventing the formation of a colored impurity when included in an ester hydrolysis reaction. Conducting ester hydrolysis in anaerobic conditions has also been found to minimize the formation of the color impurity. Also disclosed are improved methods for synthesizing the sodium salt of N-(8-[2-hydroxybenzoyl]-amino)caprylic acid.

Abstract: Disclosed are improved methods for the synthesis of N-(8-[2-hydroxybenzoyl]-amino)caprylic acid. Certain compounds have been found useful for preventing the formation of a colored impurity when included in an ester hydrolysis reaction. Conducting ester hydrolysis in anaerobic conditions has also been found to minimize the formation of the color impurity. Also disclosed are improved methods for synthesizing the sodium salt of N-(8-[2-hydroxybenzoyl]-amino)caprylic acid.

Abstract: A tape course generator produces tape course definitions for use in programming a CNC composite tape lamination machine. The tape course generator includes a reference surface parameterizer that maps a contoured surface onto a parametric reference surface, and a reference plane instantiator that maps the reference surface onto a reference plane. The tape course generator also includes a tape boundary plotter that plots a tape boundary, and a boundary mapper that maps the tape boundary and a ply boundary into the reference plane. In addition, the tape course generator includes an intersection locator that identifies intersections of the ply boundary and the tape boundary, and a tape course delimiter that defines tape cuts and determines which points in the reference plane are within a tape course. Moreover, the tape course generator includes a tape course transformer that maps the defined tape course back onto the contoured surface.

Abstract: Methods and systems for generating a curve that represents raw data are provided. In one embodiment, the system includes memory for storing a curve generation application program, a user interface, a display device, and a processor. The processor executes the stored curve generation application program and is coupled to the memory, the user interface, and the display device. The executed curve generation application program includes a first component that receives raw data and a second component that allows for the manual or default setting of a base value for defining weight values for each data point of inputted raw data. A third component generates a curve for representing the raw data based on at least a portion of the data points and the set base value. A fourth component outputs the generated curve to the display device.

Abstract: An embodiment of the present invention provides a protective layer which includes an aggregate of long chain molecules wherein each long chain molecule is randomly oriented and consistently entangled to adjacent long chain molecules throughout the aggregate of long chain molecules. Additionally, the layer is essentially free from voids and essentially free from residual stresses. By way of example and not limitation, the long chain molecule may be a plastic or liquid crystal polymer. Additionally, a method for forming the protective layer is disclosed herein.

Abstract: Disclosed herein is a method of converting a ladder logic routine into Boolean logic. Boolean representations of the ladder logic elements of the ladder logic routine are collected in respective logic expressions for each ladder rung of the plurality of ladder rungs defining the ladder logic routine. Boolean logic elements are then resolved from the logic expressions. The Boolean logic elements are then stored in a memory in an order in which the Boolean logic elements are resolved to express the ladder logic routine in accordance with an execution order of the ladder logic routine.

Abstract: Methods and systems for generating a curve that represents raw data are provided. In one embodiment, the system includes memory for storing a curve generation application program, a user interface, a display device, and a processor. The processor executes the stored curve generation application program and is coupled to the memory, the user interface, and the display device. The executed curve generation application program includes a first component that receives raw data and a second component that allows for the manual or default setting of a base value for defining weight values for each data point of inputted raw data. A third component generates a curve for representing the raw data based on at least a portion of the data points and the set base value. A fourth component outputs the generated curve to the display device.

Abstract: An embodiment of the present invention provides a protective layer which includes an aggregate of long chain molecules wherein each long chain molecule is randomly oriented and consistently entangled to adjacent long chain molecules throughout the aggregate of long chain molecules. Additionally, the layer is essentially free from voids and essentially free from residual stresses. By way of example and not limitation, the long chain molecule may be a plastic or liquid crystal polymer. Additionally, a method for forming the protective layer is disclosed herein.

Abstract: An embodiment of the present invention provides a protective layer which includes an aggregate of long chain molecules wherein each long chain molecule is randomly oriented and consistently entangled to adjacent long chain molecules throughout the aggregate of long chain molecules. Additionally, the layer is essentially free from voids and essentially free from residual stresses. By way of example and not limitation, the long chain molecule may be a plastic or liquid crystal polymer. Additionally, a method for forming the protective layer is disclosed herein.

Abstract: Methods of treating and preventing bone loss and/or enhancing bone formation are disclosed. The methods utilize 15-lipoxygenase inhibitors. These molecules can be delivered alone or in combination with agents which inhibit bone resorption or additional agents that regulate calcium resorption from bone or enhances bone accumulation. The invention additionally provides methods of diagnosing a predisposition to bone loss.