Abstract: Devices, systems, methods, and kits are provided for accessing and treating bone marrow lesions in intraosseous spaces of bones by reversibly coupling a drill, including a surgical power drill, to a stylet reversibly inserted within and coupled with a cannula to provide for concurrent or synchronized rotation of the stylet and the cannula when drilling into a bone. Also provided are devices, systems, methods, and kits for their use for uncoupling a stylet from a cannula once the cannula is in a desired position in a bone, removal of the stylet to provide an open lumen to the desired location in the bone, and reversible attachment of an access device to the proximal end of the cannula to deliver and/or withdraw a substance (such as bone graft substitute) from the accessed lesion.

Abstract: Devices, systems, methods, and kits are provided for accessing and treating bone marrow lesions in intraosseous spaces of bones by reversibly coupling a drill, including a surgical power drill, to a stylet reversibly inserted within and coupled with a cannula to provide for concurrent or synchronized rotation of the stylet and the cannula when drilling into a bone. Also provided are devices, systems, methods, and kits for their use for uncoupling a stylet from a cannula once the cannula is in a desired position in a bone, removal of the stylet to provide an open lumen to the desired location in the bone, and reversible attachment of an access device to the proximal end of the cannula to deliver and/or withdraw a substance (such as bone graft substitute) from the accessed lesion.