Patents by Inventor Frederick M. Hughson

Frederick M. Hughson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AI-2 compounds and analogs based on Salmonella typhimurium LsrB structure
    Publication number: 20090286873
    Abstract: This invention relates to crystals comprising apo-LsrB and holo-LsrB. The structure of holo-LsrB identifies a tetrahydroxytetrahydrofuran derived from 4,5-dihydroxy-2,3-pentanedione (DPD) as the active autoinducer-2 (AI-2) molecule in Salmonella typhimurium. The X-ray crystallographic data can be used in a drug discovery method. Additionally the invention provides AI-2 analogs based on this discovery as well as pharmaceutical compositions containing those analogs.
    Type: Application
    Filed: March 13, 2009
    Publication date: November 19, 2009
    Inventors: Stephen T. Miller, Karina B. Xavier, Michiko E. Taga, Shawn R. Campagna, Martin F. Semmelhack, Bonnie L. Bassler, Frederick M. Hughson
  • AI-2 compounds and analogs based on LsrB structure
    Patent number: 7547726
    Abstract: This invention relates to crystals comprising apo-LsrB and holo-LsrB. The structure of holo-LsrB identifies a tetrahydroxytetrahydrofuran derived from 4,5-dihydroxy-2,3-pentanedione (DPD) as the active autoinducer-2 (AI-2) molecule in Salmonella typhimurium. The X-ray crystallographic data can be used in a drug discovery method. Additionally the invention provides AI-2 analogs based on this discovery as well as pharmaceutical compositions containing those analogs.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: June 16, 2009
    Assignee: The Trustees of Princeton University
    Inventors: Stephen T. Miller, Karina B. Xavier, Michiko E. Taga, Shawn R. Campagna, Martin F. Semmelhack, Bonnie L. Bassler, Frederick M. Hughson
  • Crystals of LuxP and complexes thereof
    Patent number: 7208612
    Abstract: A crystal comprising LuxP is obtained, and a binding site for autoinducer-2 (AI-2) identified. The X-ray crystallographic data for LuxP and a LuxP-AI-2 complex is determined and used in a drug discovery method. Pharmaceutical compositions comprising ligands identified by such drug discovery methods are used to treat bacterial infections.
    Type: Grant
    Filed: August 22, 2002
    Date of Patent: April 24, 2007
    Assignee: Princeton University
    Inventors: Bonnie L. Bassler, Stephan Schauder, Xin Chen, Frederick M. Hughson, Stephen R. Cooper
  • Crystals of LuxP and complexes thereof
    Publication number: 20030175930
    Abstract: A crystal comprising LuxP is obtained, and a binding site for autoinducer-2 (AI-2) identified. The X-ray crystallographic data for LuxP and a LuxP-AI-2 complex is determined and used in a drug discovery method. Pharmaceutical compositions comprising ligands identified by such drug discovery methods are used to treat bacterial infections.
    Type: Application
    Filed: August 22, 2002
    Publication date: September 18, 2003
    Inventors: Bonnie L. Bassler, Stephan Schauder, Xin Chen, Frederick M. Hughson, Stephen R. Cooper