Patents by Inventor Frederick P. Roth

Frederick P. Roth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Entangled mate sequencing
    Patent number: 10385391
    Abstract: Methods and compositions are provided for performing a set of N DNA sequencing reaction cycles whereby sequence information is obtained for approximately 2*N nucleotide bases.
    Type: Grant
    Filed: September 22, 2010
    Date of Patent: August 20, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: Frederick P. Roth, Joseph C. Mellor, Yong Lu, Mark Chee
  • Synergistic Combination Therapy
    Publication number: 20140314882
    Abstract: Combinations of compounds are provided that produce a synergistic effect when administered.
    Type: Application
    Filed: June 27, 2014
    Publication date: October 23, 2014
    Inventors: Frederick P. ROTH, Murat COKOL, Hon Nian CHUA
  • Synergistic Combination Therapy
    Publication number: 20120277193
    Abstract: Combinations of compounds are provided that produce a synergistic effect when administered.
    Type: Application
    Filed: September 20, 2010
    Publication date: November 1, 2012
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Frederick P. Roth, Murat Cokol, Hon Nian Chua
  • Entangled Mate Sequencing
    Publication number: 20120245039
    Abstract: Methods and compositions are provided for performing a set of N DNA sequencing reaction cycles whereby sequence information is obtained for approximately 2*N nucleotide bases.
    Type: Application
    Filed: September 22, 2010
    Publication date: September 27, 2012
    Applicant: President and Fellows of Harvard College
    Inventors: Frederick P. Roth, Joseph C. Mellor, Yong Lu, Mark Chee
  • Methods and applications for stitched DNA barcodes
    Patent number: 8268564
    Abstract: Methods of identifying the genotypes of a plurality of single cells, wherein each cell includes a plurality of DNA barcodes, each associated with a genetic mutation or marker, are provided. In particular, methods including linking a plurality of DNA barcodes together to create a stitched barcode, amplifying the stitched barcode and sequencing the stitched barcode are provided. Also provided are methods of determining the presence of at least one genetic mutation in a population of cells.
    Type: Grant
    Filed: September 24, 2008
    Date of Patent: September 18, 2012
    Assignee: President and Fellows of Harvard College
    Inventors: Frederick P. Roth, Yo Suzuki, Joseph Mellor
  • METHODS AND APPLICATIONS FOR STITCHED DNA BARCODES
    Publication number: 20090098555
    Abstract: Methods of identifying the genotypes of a plurality of single cells, wherein each cell includes a plurality of DNA barcodes, each associated with a genetic mutation or marker, are provided. In particular, methods including linking a plurality of DNA barcodes together to create a stitched barcode, amplifying the stitched barcode and sequencing the stitched barcode are provided. Also provided are methods of determining the presence of at least one genetic mutation in a population of cells.
    Type: Application
    Filed: September 24, 2008
    Publication date: April 16, 2009
    Applicant: President and Fellows of Harvard College
    Inventors: Frederick P. Roth, Yo Suzuki, Joseph Mellor
  • Methods and compositions for the identification, assessment, prevention, and therapy of human cancers
    Publication number: 20030129629
    Abstract: The present invention is directed to the identification of markers that can be used to determine the sensitivity of cancer cells to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. Nucleic acid arrays were used to determine the level of expression of sequences (genes) found in 60 different solid tumor cancer cell lines selected from the NCI 60 cancer cell line series. Expression analysis was used to identify markers associated with sensitivity to certain chemotherapeutic agents.
    Type: Application
    Filed: October 16, 2002
    Publication date: July 10, 2003
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Frederick P. Roth, Christophe Van Huffel, James V. White, Andrew W. Shyjan
  • Methods and compositions for the identification, assessment, prevention and therapy of human cancers
    Publication number: 20020120004
    Abstract: The present invention is directed to the identification of markers that can be used to determine the sensitivity of cancer cells to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. Nucleic acid arrays were used to determine the level of expression of sequences (genes) found in 60 different solid tumor cancer cell lines selected from the NCI 60 cancer cell line series. Expression analysis was used to identify markers associated with sensitivity to certain chemotherapeutic agents.
    Type: Application
    Filed: February 16, 2001
    Publication date: August 29, 2002
    Inventors: Frederick P. Roth, Christophe Van Huffel, James V. White, Andrew W. Shyjan
  • Methods and compositions for the identification, assessment, prevention and therapy of human cancers
    Publication number: 20020051978
    Abstract: The present invention is directed to the identification of markers that can be used to determine the sensitivity of cancer cells to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. Nucleic acid arrays were used to determine the level of expression of sequences (genes) found in 60 different solid tumor cancer cell lines selected from the NCI 60 cancer cell line series. Expression analysis was used to identify markers associated with sensitivity to certain chemotherapeutic agents.
    Type: Application
    Filed: February 16, 2001
    Publication date: May 2, 2002
    Inventors: Frederick P. Roth, Christophe Van Huffel, James V. White, Andrew W. Shyjan