Patents by Inventor Frederick R. Maxfield

Frederick R. Maxfield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Histone deacetylase inhibitors as therapeutic agents for Niemann-Pick type C disease
    Patent number: 9333222
    Abstract: Embodiments herein relate to the field of lysosomal storage disorders, and, more specifically, to methods of treating lysosomal storage disorders such as Niemann-Pick type C disease, for instance with inhibitors of histone deacetylases, particularly inhibitors of class 1 histone deacetylases. In various embodiments, methods of treating Niemann-Pick type C disease with inhibitors of class 1 histone deacetylases are described.
    Type: Grant
    Filed: September 22, 2010
    Date of Patent: May 10, 2016
    Assignees: University of Notre Dame du Lac, Cornell University
    Inventors: Olaf Wiest, Frederick R. Maxfield, Paul Helquist
  • CLN2 TREATMENT OF ALZHEIMER'S DISEASE
    Publication number: 20110166074
    Abstract: A method of treating Alzheimer's Disease may include administering to a subject in need of such treatment a CLN2 therapeutic having beta-amyloid degradation activity.
    Type: Application
    Filed: October 18, 2007
    Publication date: July 7, 2011
    Applicant: Cornell Research Foundation, Inc.
    Inventors: Frederick R. Maxfield, Peter Lobel
  • HISTONE DEACETYLASE INHIBITORS AS THERAPEUTIC AGENTS FOR LYSOSOMAL STORAGE DISORDERS
    Publication number: 20110071109
    Abstract: Embodiments herein relate to the field of lysosomal storage disorders, and, more specifically, to methods of treating lysosomal storage disorders such as Niemann-Pick type C disease, for instance with inhibitors of histone deacetylases, particularly inhibitors of class 1 histone deacetylases. In various embodiments, methods of treating Niemann-Pick type C disease with inhibitors of class 1 histone deacetylases are described.
    Type: Application
    Filed: September 22, 2010
    Publication date: March 24, 2011
    Applicants: University of Notre Dame du Lac, Cornell University
    Inventors: Olaf Wiest, Frederick R. Maxfield, Paul Helquist
  • REDUCING CELLULAR CHOLESTEROL LEVELS AND/OR TREATING OR PREVENTING PHOSPHOLIPIDOSIS
    Publication number: 20090012148
    Abstract: Compounds disclosed herein may be used in disclosed methods for reducing the amount of cholesterol in a cell, for treating a patient suffering from a disorder characterized by cellular accumulation of cholesterol (such as Niemann-Pick Disease Type C or atherosclerosis), and/or for treating or preventing phospholipidosis. In some embodiments, the compounds may include a pyrrolone or triazine moiety.
    Type: Application
    Filed: October 31, 2006
    Publication date: January 8, 2009
    Inventors: Frederick R. Maxfield, Anthony Sauve