Abstract: A dual chamber bioreactor for producing complex, multilayer tissue, organs, organ parts, and skin replacements has been developed. The bioreactor is modular and incorporates a removable tissue culture cassette. By rotating the dual chamber bioreactor along the horizontal axis, different populations of cells with different growth requirements can be cultured on the different surfaces of the tissue culture cassette that are exposed to different media reservoirs. Culturing different populations of cells on different surfaces of the tissue culture cassette enables the production of multilayer tissue and organs. The tissue culture cassette can contain one or more discrete tissue culture sections.

Abstract: A dual chamber bioreactor for producing complex, multilayer tissue, organs, organ parts, and skin replacements has been developed. The bioreactor is modular and incorporates a removable tissue culture cassette. By rotating the dual chamber bioreactor along the horizontal axis, different populations of cells with different growth requirements can be cultured on the different surfaces of the tissue culture cassette that are exposed to different media reservoirs. Culturing different populations of cells on different surfaces of the tissue culture cassette enables the production of multilayer tissue and organs. The tissue culture cassette can contain one or more discrete tissue culture sections.

Abstract: In one embodiment, a bioreactor includes a cartridge adapted to deliver growth media to inner and outer surfaces of a tubular organ scaffold, the cartridge having a container that includes a first passage adapted to deliver a first growth medium to the inner surfaces of the tubular organ scaffold and a second passage adapted to deliver a second growth medium to the outer surfaces of the scaffold, wherein the first and second growth media are different media.

Abstract: An illumination device including an integrating sphere and at least one light source. The integrating sphere is hollow and houses the at least one light source in it. The light source can be manipulated between a first configuration and a second configuration. The illumination device emits a first spectrum of light when the light source is in the first configuration, and a second spectrum of light when the light source is in the second configuration.

Abstract: An illumination device including an integrating sphere and at least one light source. The integrating sphere is hollow and houses the at least one light source in it. The light source can be manipulated between a first configuration and a second configuration. The illumination device emits a first spectrum of light when the light source is in the first configuration, and a second spectrum of light when the light source is in the second configuration.

Abstract: A dental instrument for working with composite resin includes an elongate handle and at least one tool attached at an end of the elongate handle. The tool is heated and/or vibrationally driven, and used to engage and work dental composite resin.

Abstract: An illumination device including an integrating sphere and at least one light source. The integrating sphere is hollow and houses the at least one light source in it. The light source can be manipulated between a first configuration and a second configuration. The illumination device emits a first spectrum of light when the light source is in the first configuration, and a second spectrum of light when the light source is in the second configuration.

Abstract: A method and apparatus for curing an adhesive resin by use of light in which the resin is disposed between a bottom surface of an orthodontic bracket and a tooth surface, wherein a curing tip enhancer of the present invention directs the light onto the adhesive when the bracket is disposed within a portion of the curing tip enhancer. Preferably, the light is directed onto the adhesive resin in a direction substantially parallel to the tooth surface. A portion of the interior surface of the bore of the curing tip enhancer is disposed at an angle so that the light is reflected onto the resin. A light-reflective interior surface of the bore increases the effectiveness of the curing tip enhancer because more radiant energy is reflected onto the resin.