Patents by Inventor Frederick S. Jones

Frederick S. Jones has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of Identifying Synthetic Transcriptional and Translational Regulatory Elements, and Compositions Related to Same
    Publication number: 20090093049
    Abstract: Provided are methods of identifying oligonucleotides having transcriptional or translational activity by integrating ilie oligonucleotide into a eukaryotic cell genome such that the oligonucleotide is operatively linked to an expressible polynucleotide, and detecting a change in expression of the expressible polynucleotide due to the operatively linked oligonucleotide. Also provided are vectors useful for identifying an oligonucleotide having transcriptional or translational regulatory activity according to a method of the invention. In addition, isolated synthetic transcriptional or translational regulatory elements identified according to a method of the invention are provided, as are kits, which contain a vector useful for identifying a transcriptional or translational regulatory element, or an isolated synthetic transcriptional or translational regulatory element or plurality of such elements. Also provided are isolated transcriptional regulatory elements.
    Type: Application
    Filed: November 6, 2008
    Publication date: April 9, 2009
    Inventors: Vincent P. Mauro, Gerald M. Edelman, Stephen A. Chappell, Frederick S. Jones, Geoffrey Owens, Robyn Meech
  • Methods of identifying synthetic transcriptional and translational regulatory elements, and compositions relating to same
    Patent number: 7456273
    Abstract: Provided are methods of identifying oligonucleotides having transcriptional or translational activity by integrating ilie oligonucleotide into a eukaryotic cell genome such that the oligonucleotide is operatively linked to an expressible polynucleotide, and detecting a change in expression of the expressible polynucleotide due to the operatively linked oligonucleotide. Also provided are vectors useful for identifying an oligonucleotide having transcriptional or translational regulatory activity according to a method of the invention. In addition, isolated synthetic transcriptional or translational regulatory elements identified according to a method of the invention are provided, as are kits, which contain a vector useful for identifying a transcriptional or translational regulatory element, or an isolated synthetic transcriptional or translational regulatory element or plurality of such elements. Also provided are isolated transcriptional regulatory elements.
    Type: Grant
    Filed: November 29, 2006
    Date of Patent: November 25, 2008
    Assignee: The Scripps Research Institute
    Inventors: Vincent P. Mauro, Gerald M. Edelman, Stephen A. Chappell, Frederick S. Jones, Geoffrey Owens, Robyn Meech
  • Methods of identifying synthetic transcriptional and translational regulatory elements, and compositions relating to same
    Patent number: 7183395
    Abstract: Provided are methods of identifying oligonucleotides having transcriptional or translational activity by integrating the oligonucleotide into a eukaryotic cell genome such that the oligonucleotide is operatively linked to an expressible polynucleotide, and detecting a change in expression of the expressible polynucleotide due to the operatively linked oligonucleotide. Also provided are vectors useful for identifying an oligonucleotide having transcriptional or translational regulatory activity according to a method of the invention. In addition, isolated synthetic transcriptional or translational regulatory elements identified according to a method of the invention are provided, as are kits, which contain a vector useful for identifying a transcriptional or translational regulatory element, or an isolated synthetic transcriptional or translational regulatory element or plurality of such elements. Also provided are isolated transcriptional regulatory elements.
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: February 27, 2007
    Assignee: The Scripps Research Institute
    Inventors: Vincent P. Mauro, Gerald M. Edelman, Stephen A. Chappell, Frederick S. Jones, Geoffrey Owens, Robyn Meech
  • Methods of identifying synthetic transcriptonal and translational regulatory elements, and compositions relating to same
    Publication number: 20040005564
    Abstract: Provided are methods of identifying oligonucleotides having transcriptional or translational activity by integrating the oligonucleotide into a eukaryotic cell genome such that the oligonucleotide is operatively linked to an expressible polynucleotide, and detecting a change in expression of the expressible polynucleotide due to the operatively linked oligonucleotide. Also provided are vectors useful for identifying an oligonucleotide having transcriptional or translational regulatory activity according to a method of the invention. In addition, isolated synthetic transcriptional or translational regulatory elements identified according to a method of the invention are provided, as are kits, which contain a vector useful for identifying a transcriptional or translational regulatory element, or an isolated synthetic transcriptional or translational regulatory element or plurality of such elements. Also provided are isolated transcriptional regulatory elements.
    Type: Application
    Filed: December 9, 2002
    Publication date: January 8, 2004
    Inventors: Vincent P. Mauro, Gerald M. Edelman, Stephen A. Chappell, Frederick S. Jones, Geoffrey Owens, Robyn Meech
  • Pre-electrophoretic nucleic acid hybridization
    Patent number: 4721668
    Abstract: This invention provides a method of detecting nucleic acid molecules employing cRNA probes in a pre-electrophoretic hybridization procedure. In addition to detecting the presence of nucleic acids an additional embodiment of the invention permits a determination of the size of said nucleic acids to be made.
    Type: Grant
    Filed: July 25, 1984
    Date of Patent: January 26, 1988
    Assignee: Lifecodes Corporation
    Inventors: Frederick S. Jones, III, Jacob I. Grimberg, John P. Ford