Abstract: Disclosed are compositions and methods for delaying or preventing idiopathic preterm

Abstract: Disclosed are compositions and methods for delaying or preventing idiopathic preterm birth.

Abstract: The disclosure is directed to a method of enhancing progesterone receptor (PR) activity in a mammal, which comprises administering a composition comprising an inhibitor of FK506 binding protein 51 (FKBP51) to a mammal in need thereof, such as a pregnant human female, whereby progesterone receptor activity in the mammal is enhanced as compared to a mammal not administered the composition. The method results in an extension of the gestation period and a decreased likelihood of preterm birth and fetal growth restriction.

Abstract: Disclosed are compositions and methods for delaying or preventing idiopathic preterm birth.

Abstract: The disclosure is directed to a method of enhancing progesterone receptor (PR) activity in a mammal, which comprises administering a composition comprising an inhibitor of FK506 binding protein 51 (FKBP51) to a mammal in need thereof, such as a pregnant human female, whereby progesterone receptor activity in the mammal is enhanced as compared to a mammal not administered the composition. The method results in an extension of the gestation period and a decreased likelihood of preterm birth and fetal growth restriction.

Abstract: The present invention concerns compositions and methods for inhibition of abnormal uterine bleeding (AUB), such as that associated with use of long-acting progestin-only contraceptives (LAPCs). An aspect of the invention concerns compositions comprising chemokine (C-C motif) ligand 2 (CCL2), or a biologically active fragment thereof, which may administered to subjects for inhibition of AUB. Another aspect of the invention concerns methods for inhibiting AUB, comprising administering an effective amount of CCL2, or a biologically active fragment thereof, to a subject in need thereof. Another aspect of the invention concerns a kit for inhibiting AUB.

Abstract: The disclosure is directed to a method of enhancing progesterone receptor (PR) activity in a mammal, which comprises administering a composition comprising an inhibitor of FK506 binding protein 51 (FKBP51) to a mammal in need thereof, such as a pregnant human female, whereby progesterone receptor activity in the mammal is enhanced as compared to a mammal not administered the composition. The method results in an extension of the gestation period and a decreased likelihood of preterm birth and fetal growth restriction.

Abstract: An ophthalmic surgical instrument comprises a multi-diameter shaft, a horn fixedly threaded into the shaft, a surgical tip for ophthalmic surgery including a tip end and threadably engaging the horn opposite the shaft, and a plug on the shaft. Weld material holds the plug on the shaft in a selected angular and longitudinal position with an angle-locating recess on the plug's circumference having a predetermined angular clocked relation to a face direction of the tip end. The plug's recess engages an irrigation tube on a subassembled handle with shell and irrigation tube, such that the subassembled handle has a known clocked position relative to the tip end of the tip, thus facilitating use by a surgeon. A related method is also disclosed and claimed.

Abstract: The present invention concerns compositions and methods for inhibition of abnormal uterine bleeding (AUB), such as that associated with use of long-acting progestin-only contraceptives (LAPCs). An aspect of the invention concerns compositions comprising chemokine (C-C motif) ligand 2 (CCL2), or a biologically active fragment thereof, which may administered to subjects for inhibition of AUB. Another aspect of the invention concerns methods for inhibiting AUB, comprising administering an effective amount of CCL2, or a biologically active fragment thereof, to a subject in need thereof. Another aspect of the invention concerns a kit for inhibiting AUB.

Abstract: An ophthalmic surgical instrument comprises a multi-diameter shaft, a horn fixedly threaded into the shaft, a surgical tip for ophthalmic surgery including a tip end and threadably engaging the horn opposite the shaft, and a plug on the shaft. Weld material holds the plug on the shaft in a selected angular and longitudinal position with an angle-locating recess on the plug's circumference having a predetermined angular clocked relation to a face direction of the tip end. The plug's recess engages an irrigation tube on a subassembled handle with shell and irrigation tube, such that the subassembled handle has a known clocked position relative to the tip end of the tip, thus facilitating use by a surgeon. A related method is also disclosed and claimed.

Abstract: An ophthalmic surgical instrument comprises a multi-diameter shaft, a horn fixedly threaded into the shaft, a surgical tip for ophthalmic surgery including a tip end and threadably engaging the horn opposite the shaft, and a plug on the shaft. Weld material holds the plug on the shaft in a selected angular and longitudinal position with an angle-locating recess on the plug's circumference having a predetermined angular clocked relation to a face direction of the tip end. The plug's recess engages an irrigation tube on a subassembled handle with shell and irrigation tube, such that the subassembled handle has a known clocked position relative to the tip end of the tip, thus facilitating use by a surgeon. A related method is also disclosed and claimed.

Abstract: An ophthalmic surgical instrument comprises a multi-diameter shaft, a horn fixedly threaded into the shaft, a surgical tip for ophthalmic surgery including a tip end and threadably engaging the horn opposite the shaft, and a plug on the shaft. Weld material holds the plug on the shaft in a selected angular and longitudinal position with an angle-locating recess on the plug's circumference having a predetermined angular clocked relation to a face direction of the tip end. The plug's recess engages an irrigation tube on a subassembled handle with shell and irrigation tube, such that the subassembled handle has a known clocked position relative to the tip end of the tip, thus facilitating use by a surgeon. A related method is also disclosed and claimed.