Abstract: The system and method of the invention combines target image intensity into a maximum likelihood estimate (MLE) framework as in STAPLE to take advantage of both intensity-based segmentation and statistical label fusion based on atlas consensus and performance level, abbreviated iSTAPLE. The MLE framework is then solved using a modified expectation-maximization algorithm to simultaneously estimate the intensity profiles of structures of interest as well as the true segmentation and atlas performance level. The iSTAPLE greatly extends the use of atlases such that the target image need not have the same image contrast and intensity range as the atlas images.

Abstract: In embodiments of the invention, the habenulae have been identified and localized in normal volunteers. Aspects of the invention determine the location, volume and magnetic susceptibility of the habenulae. Furthermore, diagnosing and monitoring patient disorders are enabled using the herein disclosed methodologies and techniques.

Abstract: The system and method of the invention combines target image intensity into a maximum likelihood estimate (MLE) framework as in STAPLE to take advantage of both intensity-based segmentation and statistical label fusion based on atlas consensus and performance level, abbreviated iSTAPLE. The MLE framework is then solved using a modified expectation-maximization algorithm to simultaneously estimate the intensity profiles of structures of interest as well as the true segmentation and atlas performance level. The iSTAPLE greatly extends the use of atlases such that the target image need not have the same image contrast and intensity range as the atlas images.

Abstract: Methods and apparatus for fabricating a magnetic resonance imaging (MRI) gradient coil for generating magnetic field gradients are provided. The method includes determining a pattern of gradient current paths on a surface using a set of stream functions oriented in at least one of a z-gradient, a y-gradient; and an x-gradient, and arranging conductive material to define a current path that conforms to the determined gradient current paths.

Abstract: Methods and apparatus for fabricating a magnetic resonance imaging (MRI) gradient coil for generating magnetic field gradients are provided. The method includes determining a pattern of gradient current paths on a surface using a set of stream functions oriented in at least one of a z-gradient, a y-gradient; and an x-gradient, and arranging conductive material to define a current path that conforms to the determined gradient current paths.

Abstract: A radio frequency (RF) coil assembly for a very high field Magnetic Resonance Imaging (MRI) system is provided comprising a plurality of conductors arranged cylindrically and disposed about a cylindrical patient bore tube of the MRI system and a plurality of capacitive elements for electrically interconnecting the plurality of conductors at respective ends of the conductors. The conductors have a width selected for the RF coil assembly to resonate at substantially high frequencies. A very high field Magnetic Resonance Imaging (MRI) system is provided that comprises a RF coil assembly adapted to resonate at substantially high frequencies, a RF coil shield assembly and a plurality of RF drive power cables.

Abstract: A method and system for detecting iron using magnetic resonance imaging (MRI) is provided. The method comprises acquiring magnetic resonance (MR) images by a selected pulse sequence to enhance brain iron deposits using a MRI system having a substantially high magnetic field strength and characterizing regions of interest within the MR images having statistically relevant quantities of iron deposits to indicate a given disease.

Abstract: A radio frequency (RF) coil assembly for a very high field Magnetic Resonance Imaging (MRI) system is provided. The RF coil assembly comprises a plurality of conductors arranged cylindrically and disposed about a patient bore tube of the MRI system. Each of the conductors is configured for the RF coil assembly to resonate at substantially high frequencies. Further, the RF coil assembly comprises a plurality of capacitive elements disposed between and connecting respective ends of the conductors and further disposed in a spaced-apart relationship with the patient bore tube. The capacitive elements are for electrically interconnecting the plurality of conductors at the respective ends of the conductors.

Abstract: A radio frequency (RF) coil assembly for a very high field Magnetic Resonance Imaging (MRI) system is provided. The RF coil assembly comprises a plurality of conductors arranged cylindrically and disposed about a patient bore tube of the MRI system. Each of the conductors is configured for the RF coil assembly to resonate at substantially high frequencies. Further, the RF coil assembly comprises a plurality of capacitive elements disposed between and connecting respective ends of the conductors and further disposed in a spaced-apart relationship with the patient bore tube. The capacitive elements are for electrically interconnecting the plurality of conductors at the respective ends of the conductors.

Abstract: A radio frequency (RF) coil assembly for a very high field Magnetic Resonance Imaging (MRI) system is provided comprising a plurality of conductors arranged cylindrically and disposed about a cylindrical patient bore tube of the MRI system and a plurality of capacitive elements for electrically interconnecting the plurality of conductors at respective ends of the conductors. The conductors have a width selected for the RF coil assembly to resonate at substantially high frequencies. A very high field Magnetic Resonance Imaging (MRI) system is provided that comprises a RF coil assembly adapted to resonate at substantially high frequencies, a RF coil shield assembly and a plurality of RF drive power cables.

Abstract: A quadrature coil suitable for use with an open frame MRI system provides crossing pairs of arrays of parallel conductor elements, respectively. Compact configuration is provided through use of an isolating circuit for incorporating parasitic capacitances at the resonance frequency of the coil into a blocking parallel resonance. Termination of the parallel conductor elements may be accomplished by equal impedance node connectors formed from branching pairs of conductors or a triangular least resistance connection form. RF shields are provided by pairs of conductive sheets containing eddy current reducing slots aligned with the parallel conductors elements of the coil.

Abstract: Instruments are constructed of a carbon fiber material optionally doped with a doping agent such as iron oxide, the instrument having a magnetic susceptibility being adjusted to a portion of a subject being imaged. Therefore there is little effect upon the lines of magnetic flux and the magnetic field homogeneity, reducing distortion in an MR image. These carbon fiber instruments exhibit virtually no magnetic torsional forces when inserted into a magnetic field. This is important, for example when the instrument is a scalpel. Doped carbon fiber has minimal affect on radiofrequency fields. The instruments do not affect the homogeneity of an applied homogeneous magnetic field or an applied radiofrequency field. Doped carbon fiber exhibits a rigidity large enough to allow construction of high strength instruments such as biopsy needles. It also has the ability to retain a sharp edge, allowing construction of scalpels and cutting instruments.

Abstract: Etching methods are employed on a thin conducting sheet so as to fabricate complicated magnetic coil patterns which are necessary to produce magnetic fields of high uniformity or other given design. The etching is performed so that material is removed along a thin line or lines which correspond to current streamlines of the ideal current distribution so that the remaining material exhibits a relatively wide region of conducting material having reduced electrical resistance.