Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: W—X—Y—Z (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Abstract: A rim raising device attaches to a drum rim, or operates remotely from a drum. The device provides additional elevation above the drum, and increased surface area to a section of the drum rim such that a percussion technique is enhanced. The increased elevation provides space for other components to attach to the drum rim. A trigger assembly comprises at least one piezoelectric sensor and/or at least one force sensor that detect the force. The piezoelectric sensor generates an intensity sensitive signal. The force sensor generates an on/off, linear signal that produces sound, or serves as a gate for the piezoelectric sensor. The force converts into both types of signals, and wirelessly transmitted to a sound module for generating a predetermined sound. A transmitter on the device uses wireless technology, or an instrument cable/wire to transmit the signal. A vibration suppression portion inhibits interferences and other unwanted vibrations.

Abstract: A rim raising device attaches to a drum rim, or operates remotely from a drum. The device provides additional elevation above the drum, and increased surface area to a section of the drum rim such that a percussion technique is enhanced. The increased elevation provides space for other components to attach to the drum rim. A trigger assembly comprises at least one piezoelectric sensor and/or at least one force sensor that detect the force. The piezoelectric sensor generates an intensity sensitive signal. The force sensor generates an on/off, linear signal that produces sound, or serves as a gate for the piezoelectric sensor. The force converts into both types of signals, and wirelessly transmitted to a sound module for generating a predetermined sound. A transmitter on the device uses wireless technology, or an instrument cable/wire to transmit the signal. A vibration suppression portion inhibits interferences and other unwanted vibrations.

Abstract: A drum rim raising device that is attachable to an existing drum structure, comprising an arc section of a drum rim configured to be secured to the existing drum housing. The rim raising device is configured to support a triggering system.

Abstract: Randomized load balancing across a selected subset of routing nodes is shown to achieve near-optimal usage of network resources, yet alleviates “single point of failure” problems associated with existing hub routing techniques.