Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as Leishmaniasis, Human African Trypanosomiasis and Chagas disease.

Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as Leishmaniasis, Human African Trypanosomiasis and Chagas disease.

Abstract: A microtitre plate having a relieved perimeter includes a plate defining a plurality of wells and the perimeter of the plate is horizontally relieved. Alternatively, a microtitre plate may include a base and a holding section extending from the base. The holding section defines a plurality of wells and the perimeter thereof being horizontally relieved.

Abstract: A method and system are provided for automatically controlling tension of an armour tape being wrapped around a continuous strand of material, such as an electrical cable, travelling through an armouring machine having a reel of tape and tape feed rolls rotating around the strand and having a motor or suitable variable speed drive (such as a P.I.V. variable speed drive) for controlling the speed of rotation of the tape feed rolls and thus of tape feed rate. To achieve automatic control, the diameter of the strand entering the machine is measured, preferably by a laser, and the diameter of the armour over the strand exiting the machine is also measured, also preferably by a laser. The measurements are communicated to a computer which compares them to preset values. The computer drives the motor or variable speed drive and adjusts them when required depending on the measurements of the two diameters and so as to maintain the preset values during the wrapping operation.

Abstract: A screw head is provided with projections on selected of the driver-engageable surfaces of the head to interlock with surfaces and edges of the driver to reduce the tendency for the driver to slip out of the recess during driving and also to provide a temporary stick-fit between the driver and the recess.

Abstract: A punch for forming a screw head is provided with grooves which will form projections on selected of the driver-engageable surfaces of the head. The projections are arranged to interlock with surfaces and edges of the driver to reduce the tendency for the driver to slip out of the recess during driving and also to provide a temporary stick-fit between the driver and the recess.

Abstract: A screw head is provided with projections on selected of the driver-engageable surfaces of the head to interlock with surfaces and edges of the driver to reduce the tendency for the driver to slip out of engagement with the screw during driving and also to provide a temporary stick-fit between the driver and the screw.