Abstract: Medical syringe barrels having the inner surface coated with cured silicone oil are used for calibration and detection of silicone oil in medical syringe barrels. Calibration standards as provided in this invention allow for quick determination how well a lubrication system for lubricating medical syringe barrels with silicone oil is working.

Abstract: A stable biopolymer-based emulsion lubricant including Agar is provided to reduce the friction between a syringe barrel plunger and the interior surface of the syringe barrel. According to exemplary embodiments the emulsion has a friction of less than 4N, the emulsion is temperature stable in a range of 4-23 degrees Celsius and the emulsion is stable for a period of at least 60 days.

Abstract: A method is provided of using morphologically specific free-floating structures as Standards in the pharmaceutical industry to test objects in drug containers. These structures are micropatterned according to a desired pattern. A container is filled with a defined number of the standards, which then can be used as a standard reference for testing other drug products held in a drug container. The testing pertains to optically identifying structures in the drug container that can be similar in size and shape as the standards, or that can be different in size and shape as the standards. The advantage of the method is that imaging systems with tracking algorithms that count and track sub-visible and visible particles in solution can be used to identify e.g. glass flakes and other foreign particles by comparing them to the shape and size of the standard reference particles.

Abstract: A self-lubricating medical syringe is provided for self-lubricating the inner surface of a prefilled syringe barrel. The syringe has a plunger distinguishing a compressible porous cylinder, which can be infused with a lubricant and is sandwiched in between a proximal and distal rubber tip. The self-lubricating medical syringe will be able to compensate for any missing lubricant along the inner surface of the syringe barrel and will also be able to provide for a uniform motion of the plunger.

Abstract: A tracking and tracing method is provided during the life of the pharmaceutical container to improve the safety and efficacy of the pharmaceutical container and its content. An identification code is added to the surface of the pharmaceutical container, which is not visible under ambient light. The identification code contains encrypted information regarding temporal and physical properties of the pharmaceutical container and pharmaceutical fluid content. At multiple stages during the life of the pharmaceutical container the identification code is detected with an optical detection method. Given the material of the identification code, the identification code is only visible by using specific optical detection methods.

Abstract: A method is provided of using morphologically specific free-floating structures as Standards in the pharmaceutical industry to test objects in drug containers. These structures are micropatterned according to a desired pattern. A container is filled with a defined number of the standards, which then can be used as a standard reference for testing other drug products held in a drug container. The testing pertains to optically identifying structures in the drug container that can be similar in size and shape as the standards, or that can be different in size and shape as the standards. The advantage of the method is that imaging systems with tracking algorithms that count and track sub-visible and visible particles in solution can be used to identify e.g. glass flakes and other foreign particles by comparing them to the shape and size of the standard reference particles.

Abstract: Medical syringe barrels having the inner surface coated with cured silicone oil are used for calibration and detection of silicone oil in medical syringe barrels. Calibration standards as provided in this invention allow for quick determination how well a lubrication system for lubricating medical syringe barrels with silicone oil is working.

Abstract: A self-lubricating medical syringe is provided for self-lubricating the inner surface of a prefilled syringe barrel. The syringe has a plunger distinguishing a compressible porous cylinder, which can be infused with a lubricant and is sandwiched in between a proximal and distal rubber tip. The self-lubricating medical syringe will be able to compensate for any missing lubricant along the inner surface of the syringe barrel and will also be able to provide for a uniform motion of the plunger.

Abstract: A stable biopolymer-based emulsion lubricant including Agar is provided to reduce the friction between a syringe barrel plunger and the interior surface of the syringe barrel. According to exemplary embodiments the emulsion has a friction of less than 4N, the emulsion is temperature stable in a range of 4-23 degrees Celsius and the emulsion is stable for a period of at least 60 days.

Abstract: A quality control method or system for determining a lubricant coverage at the inside surface of a syringe barrel is provided. The timing for the quality control is not intuitive, yet crucial for patient's safety. The pre-fill test is for a pre-filled (empty or no drug solution), yet oil lubricated, barrel. This pre-fill test needs to be performed within a certain time window immediately following the lubrication. The post-fill test is for a post-filled oil lubricated syringe barrel filled with a solution. This post-fill test needs to be performed after a certain time window has passed from the filling with the solution. The quality control methods could lead to a reduction of health-risks or avoid life-threatening situations associated with syringes that are either below or above the desired lubrication coverage.

Abstract: A quality control method or system for determining a lubricant coverage at the inside surface of a syringe barrel is provided. The timing for the quality control is not intuitive, yet crucial for patient's safety. The pre-fill test is for a pre-filled (empty or no drug solution), yet oil lubricated, barrel. This pre-fill test needs to be performed within a certain time window immediately following the lubrication. The post-fill test is for a post-filled oil lubricated syringe barrel filled with a solution. This post-fill test needs to be performed after a certain time window has passed from the filling with the solution. The quality control methods could lead to a reduction of health-risks or avoid life-threatening situations associated with syringes that are either below or above the desired lubrication coverage.