Patents by Inventor Frederick W. Hartner

Frederick W. Hartner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for preparing bicyclo [3.1.0] hexane derivatives, and intermediates thereto
    Patent number: 7786314
    Abstract: Processes for the preparation of certain [3.1.0]hexane derivatives which are useful as mGluR agonists, and intermediates prepared during such processes.
    Type: Grant
    Filed: November 3, 2004
    Date of Patent: August 31, 2010
    Assignee: Taisho Pharmaceutical Co., Ltd
    Inventors: Frederick W. Hartner, Lushi Tan, Nobuyoshi Yasuda, Naoki Yoshikawa
  • Process for synthesizing a substituted pyrazole
    Patent number: 7709658
    Abstract: The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.
    Type: Grant
    Filed: July 21, 2006
    Date of Patent: May 4, 2010
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Lushi Tan, James Christopher McWilliams, Frederick W. Hartner, Naoki Yoshikawa, Wenji Li
  • 4-Oxo-1-3-Substituted Phenyl-1,4-Dihydro-1,8-Napthyridene-3-Carboxamide Phosphodiesterase-4 Inhibitor and a Method of Preparing Same
    Publication number: 20090105479
    Abstract: The invention is directed to a compound of the structural formula (22) (22) crystal form of structural formulae (21) and its free acid, pharmaceutical compositions comprising these compounds and methods of preparing and using these compounds.
    Type: Application
    Filed: October 24, 2006
    Publication date: April 23, 2009
    Applicant: MERCK & CO., INC.
    Inventors: Mark Cameron, Frederick W. Hartner, Lushi Tan, Nobuyoshi Yasuda, Naoki Yoshikawa
  • Process for synthesizing a substituted pyrazole
    Publication number: 20090054662
    Abstract: The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.
    Type: Application
    Filed: July 21, 2006
    Publication date: February 26, 2009
    Inventors: Lushi Tan, James Christopher McWilliams, Frederick W. Hartner, Naoki Yoshikawa, Wenji Li
  • Process for making fluorinated 4-azasteroid derivatives
    Patent number: 7301026
    Abstract: The present invention relates to synthetic processes useful in the preparation of fluorinated 4-azasteroid derivatives that modulate androgen receptors and have application in the treatment of conditions caused by androgen deficiency or androgen receptor hyperactivity, such as osteoporosis, periodontal disease, bone fracture, frailty, erectile dysfunction, loss of libido, androgen-dependent cancers and sarcopenia. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.
    Type: Grant
    Filed: April 24, 2006
    Date of Patent: November 27, 2007
    Assignee: Merck & Co., Inc
    Inventors: Lushi Tan, Benjamin T. Dorner, Wenjie Li, Nobuyoshi Yasuda, Frederick W. Hartner
  • Process for preparing integrin antagonist intermediates
    Patent number: 6706885
    Abstract: A novel process is provided for the preparation of optionally protected 2,5-di-(3′-aminopropyl)-pyridines which are useful in the synthesis of &agr;v integrin receptor antagonists. Also provided are useful intermediates obtained from the process.
    Type: Grant
    Filed: June 5, 2002
    Date of Patent: March 16, 2004
    Assignee: Merck & Co., Inc.
    Inventors: Nobuyoshi Yasuda, Michael Palucki, Yi Xiao, Frederick W. Hartner, Lushi Tan
  • Process for preparing integrin antagonist intermediates
    Publication number: 20030004353
    Abstract: A novel process is provided for the preparation of optionally protected 2,5-di-(3′-aminopropyl)-pyridines which are useful in the synthesis of &agr;v integrin receptor antagonists. Also provided are useful intermediates obtained from the process.
    Type: Application
    Filed: June 5, 2002
    Publication date: January 2, 2003
    Inventors: Nobuyoshi Yasuda, Michael Palucki, Yi Xiao, Frederick W. Hartner, Lushi Tan
  • Process for preparing substituted azetidinones
    Patent number: 5808056
    Abstract: The present invention relates to the process for the preparation of the substituted azetidinone having the formula: ##STR1## comprising a convergent synthesis wherein the azetidinone portion of the molecule is coupled to the lower benzodioxole portion via a base catalyzed addition to an isocyanate.
    Type: Grant
    Filed: October 23, 1996
    Date of Patent: September 15, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Joseph S. Amato, Raymond Cvetovich, Frederick W. Hartner
  • Process for solubilizing polyanoinic bacterial polysaccharides in aprotic solvents
    Patent number: 4963534
    Abstract: A process for rendering a bacterial polysaccharide soluble in aprotic solvents by exchanging the calcium counterion of a polysaccharide calcium salt for tetra-n-alkylammonium ion by precipitation.
    Type: Grant
    Filed: May 19, 1989
    Date of Patent: October 16, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Ralph Calabria, Frederick W. Hartner, John T. Sisko