Patents by Inventor Frederick W. Jacobsen

Frederick W. Jacobsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROTEINS SPECIFIC FOR BAFF AND B7RP1 AND USES THEREOF
    Publication number: 20230128444
    Abstract: Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.
    Type: Application
    Filed: September 28, 2022
    Publication date: April 27, 2023
    Applicant: AMGEN INC.
    Inventors: Hailing HSU, Ming ZHANG, Gunasekaran KANNAN, Frederick W. JACOBSEN, Wayne H. TSUJI
  • DKK1 ANTIBODIES AND METHODS OF USE
    Publication number: 20210040189
    Abstract: The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.
    Type: Application
    Filed: September 9, 2020
    Publication date: February 11, 2021
    Applicant: AMGEN INC.
    Inventors: William Gleason RICHARDS, Hsieng Sen LU, Hua Zhu KE, Chaoyang LI, Frederick W. JACOBSEN
  • DKK1 antibodies and methods of use
    Patent number: 10800839
    Abstract: The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: October 13, 2020
    Assignee: AMGEN INC.
    Inventors: William Gleason Richards, Hsieng Sen Lu, Hua Zhu Ke, Chaoyang Li, Frederick W. Jacobsen
  • Proteins specific for BAFF and B7RP1 and uses thereof
    Patent number: 10421823
    Abstract: Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: September 24, 2019
    Assignee: AMGEN INC.
    Inventors: Hailing Hsu, Ming Zhang, Gunasekaran Kannan, Frederick W. Jacobsen, Wayne Tsuji
  • STABILIZATION OF FC-CONTAINING POLYPEPTIDES
    Publication number: 20190192628
    Abstract: This disclosure provides polypeptides comprising an antibody Fc region having a deletion of one or more cysteine residues in the hinge region and substitution with a sulfhydryl-containing residue of one or more CH3-interface amino acids. Also, provided are Fc-fusion proteins and antibodies containing said polypeptides, nucleic acids and vectors encoding said polypeptides, along with host cells and methods for making said polypeptides.
    Type: Application
    Filed: March 8, 2019
    Publication date: June 27, 2019
    Applicant: AMGEN INC.
    Inventors: Gunasekaran KANNAN, Jennifer LAVALLEE, Frederick W. JACOBSEN
  • Carrier immunoglobulins
    Patent number: 10189912
    Abstract: Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: January 29, 2019
    Assignee: AMGEN INC.
    Inventors: Kenneth W. Walker, Yue-Sheng Li, Thomas Charles Boone, George Doellgast, HoSung Min, Jane Talvenheimo, Taruna Arora, Frederick W. Jacobsen
  • DKK1 ANTIBODIES AND METHODS OF USE
    Publication number: 20180111985
    Abstract: The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.
    Type: Application
    Filed: December 13, 2017
    Publication date: April 26, 2018
    Applicant: Amgen Inc.
    Inventors: William Gleason RICHARDS, Hsieng Sen LU, Hua Zhu KE, Chaoyang LI, Frederick W. JACOBSEN
  • DKK1 antibodies and methods of use
    Patent number: 9879072
    Abstract: The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: January 30, 2018
    Assignee: AMGEN INC.
    Inventors: William Gleason Richards, Hsieng Sen Lu, Hua Zhu Ke, Chaoyang Li, Frederick W. Jacobsen
  • Carrier immunoglobulins and uses thereof
    Patent number: 9803019
    Abstract: Disclosed is an isolated immunoglobulin. Also disclosed are pharmaceutical compositions and medicaments comprising the immunoglobulin, isolated nucleic acid encoding it, vectors, host cells, useful in methods of making it. In some embodiments the immunoglobulin comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: October 31, 2017
    Assignee: AMGEN INC.
    Inventors: Kenneth W. Walker, Frederick W. Jacobsen, Taruna Arora
  • CARRIER IMMUNOGLOBULINS
    Publication number: 20170190793
    Abstract: Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
    Type: Application
    Filed: January 12, 2017
    Publication date: July 6, 2017
    Applicant: AMGEN INC.
    Inventors: Kenneth W. WALKER, Yue-Sheng LI, Thomas Charles BOONE, George DOELLGAST (DECEASED), HoSung MIN, Jane TALVENHEIMO, Taruna ARORA, Frederick W. JACOBSEN
  • Carrier immunoglobulins
    Patent number: 9562108
    Abstract: Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: February 7, 2017
    Assignee: AMGEN INC.
    Inventors: Kenneth W. Walker, Yue-Sheng Li, Thomas Charles Boone, HoSung Min, Jane Talvenheimo, Taruna Arora, Frederick W. Jacobsen
  • Carrier immunoglobulins
    Patent number: 9562107
    Abstract: Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: February 7, 2017
    Assignee: AMGEN INC.
    Inventors: Kenneth W. Walker, Yue-Sheng Li, Thomas Charles Boone, George Doellgast, HoSung Min, Jane Talvenheimo, Taruna Arora, Frederick W. Jacobsen
  • Proteins specific for BAFF and B7RP1
    Patent number: 9458246
    Abstract: Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: October 4, 2016
    Assignee: AMGEN INC.
    Inventors: Hailing Hsu, Ming Zhang, Gunasekaran Kannan, Frederick W. Jacobsen, Wayne Tsuji
  • STABILIZATION OF FC-CONTAINING POLYPEPTIDES
    Publication number: 20160193295
    Abstract: This disclosure provides polypeptides comprising an antibody Fc region having a deletion of one or more cysteine residues in the hinge region and substitution with a sulfhydryl-containing residue of one or more CH3-interface amino acids. Also, provided are Fc-fusion proteins and antibodies containing said polypeptides, nucleic acids and vectors encoding said polypeptides, along with host cells and methods for making said polypeptides.
    Type: Application
    Filed: July 30, 2014
    Publication date: July 7, 2016
    Applicant: AMGEN INC.
    Inventors: Gunasekaran KANNAN, Jennifer LAVALLEE, Frederick W. JACOBSEN
  • PROTEINS SPECIFIC FOR BAFF AND B7RP1 AND USES THEREOF
    Publication number: 20160024225
    Abstract: Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.
    Type: Application
    Filed: March 12, 2014
    Publication date: January 28, 2016
    Inventors: Hailing Hsu, Ming Zhang, Gunasekaran Kannan, Frederick W. Jacobsen, Wayne Tsuji
  • CARRIER IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20150232566
    Abstract: Disclosed is an isolated immunoglobulin. Also disclosed are pharmaceutical compositions and medicaments comprising the immunoglobulin, isolated nucleic acid encoding it, vectors, host cells, useful in methods of making it. In some embodiments the immunoglobulin comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
    Type: Application
    Filed: February 20, 2015
    Publication date: August 20, 2015
    Applicant: AMGEN INC.
    Inventors: Kenneth W. WALKER, Frederick W. JACOBSEN, Taruna Arora
  • Carrier immunoglobulins and uses thereof
    Patent number: 8993727
    Abstract: Disclosed is an isolated immunoglobulin. Also disclosed are pharmaceutical compositions and medicaments comprising the immunoglobulin, isolated nucleic acid encoding it, vectors, host cells, useful in methods of making it. In some embodiments the immunoglobulin comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: March 31, 2015
    Assignee: Amgen Inc.
    Inventors: Kenneth W. Walker, Frederick W. Jacobsen, Taruna Arora
  • CARRIER IMMUNOGLOBULINS
    Publication number: 20150044236
    Abstract: Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
    Type: Application
    Filed: May 22, 2014
    Publication date: February 12, 2015
    Applicant: AMGEN INC.
    Inventors: Kenneth W. WALKER, Yue-Sheng LI, Thomas Charles BOONE, HoSung MIN, Jane TALVENHEIMO, Taruna ARORA, Frederick W. JACOBSEN
  • CARRIER IMMUNOGLOBULINS
    Publication number: 20150044235
    Abstract: Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.
    Type: Application
    Filed: May 22, 2014
    Publication date: February 12, 2015
    Applicant: Amgen Inc.
    Inventors: Kenneth W. WALKER, Yue-Sheng LI, Thomas Charles BOONE, George DOELLGAST (DECEASED), HoSung MIN, Jane TALVENHEIMO, Taruna ARORA, Frederick W. JACOBSEN
  • PROTEINS SPECIFIC FOR BAFF AND B7RP1
    Publication number: 20140302036
    Abstract: Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.
    Type: Application
    Filed: March 10, 2014
    Publication date: October 9, 2014
    Applicant: Amgen Inc.
    Inventors: Hailing HSU, Ming ZHANG, Gunasekaran KANNAN, Frederick W. JACOBSEN, Wayne TSUJI