Abstract: Polymer compositions comprising, inter alia, at least two hydrophilic polymers and a crosslinking reagent, biosurfaces comprising such polymer compositions, and methods of creating such biosurfaces by disposing such polymer compositions on sensor surfaces are provided. Sensor surfaces coated with such polymer compositions and biosurfaces are amenable, inter alia, to use in methods and devices for detecting, measuring, and/or quantifying one or more analytes in one or more query samples.