Patents by Inventor Frederik Jan Rita Rombouts

Frederik Jan Rita Rombouts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BRANCHED MACROCYCLIC 4-(PYRAZOL-5-YL)-INDOLE DERIVATIVES AS INHIBITORS OF MCL-1
    Publication number: 20240124487
    Abstract: The present invention relates to pharmaceutical agents of formula (I) useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.
    Type: Application
    Filed: December 16, 2021
    Publication date: April 18, 2024
    Inventors: Frederik Jan Rita ROMBOUTS, Adriana-Ingrid VELTER, Petrus Jacobus Johannes Antonius BUIJNSTERS, Sofia FERRER CABRERA
  • MACROCYCLIC BRANCHED 3-FLUORO-BUT-3-ENAMIDES AS INHIBITORS OF MCL-1
    Publication number: 20240083890
    Abstract: The present invention relates to pharmaceutical agents of formula (I) useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.
    Type: Application
    Filed: December 16, 2021
    Publication date: March 14, 2024
    Inventors: Meng-Yang HSIAO, Soufyan JERHAOUI, Frederik Jan Rita ROMBOUTS, Michel SURKYN, Matthieu Dominique JOUFFROY
  • MACROCYCLIC SPIROCYCLE DERIVATIVES AS MCL-1 INHIBITORS
    Publication number: 20240067660
    Abstract: The present invention relates to pharmaceutical agents of formula (I) useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.
    Type: Application
    Filed: July 7, 2020
    Publication date: February 29, 2024
    Inventors: Frederik Jan Rita ROMBOUTS, Gaston Stanislas Marcella DIELS, Soufyan JERHAOUI, Michel SURKYN, Yves Emiel Maria VAN ROOSBROECK, Matthieu Dominique JOUFFROY
  • MACROCYCLIC 7-PYRAZOL-5-YL-INDOLE DERIVATIVES AS INHIBITORS OF MCL-1
    Publication number: 20230265105
    Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.
    Type: Application
    Filed: May 27, 2021
    Publication date: August 24, 2023
    Inventors: Frederik Jan Rita ROMBOUTS, Aldo PESCHIULLI, Samuël Dominique DEMIN, Adriana-Ingrid VELTER, Matthieu Dominique JOUFFROY
  • MACROCYCLIC ETHER CONTAINING INDOLE DERIVATIVES AS INHIBITORS OF MCL-1
    Publication number: 20230250109
    Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.
    Type: Application
    Filed: July 8, 2021
    Publication date: August 10, 2023
    Inventors: Benoît Christian Albert Ghislain DE BOECK, Petrus Jacobus Johannes Antonius BUIJNSTERS, Sofia FERRER CABRERA, Aldo PESCHIULLI, Tristan REUILLON, Frederik Jan Rita ROMBOUTS, Adriana-Ingrid VELTER
  • N-LINKED MACROCYCLIC 7-(PYRAZOL-5-YL)-INDOLE DERIVATIVES AS INHIBIORS OF MCL-1
    Publication number: 20230234969
    Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.
    Type: Application
    Filed: June 18, 2021
    Publication date: July 27, 2023
    Inventors: Frederik Jan Rita ROMBOUTS, Benoit Christian Albert Ghislain DE BOECK, Aldo PESCHIULLI, Adriana-Ingrid VELTER
  • N-LINKED MACROCYCLIC 4-(PYRAZOL-5-YL)-INDOLE DERIVATIVES AS INHIBITORS OF MCL-1
    Publication number: 20230234965
    Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.
    Type: Application
    Filed: June 18, 2021
    Publication date: July 27, 2023
    Inventors: Aldo PESCHIULLI, Frederik Jan Rita ROMBOUTS, Adriana-Ingrid VELTER
  • MACROCYCLIC-2-AMINO-3-FLUORO-BUT-3-ENAMIDES AS INHIBITORS OF MCL-1
    Publication number: 20230219906
    Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds (formula (I)), and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.
    Type: Application
    Filed: June 9, 2021
    Publication date: July 13, 2023
    Inventors: Soufyan JERHAOUI, Frederik Jan Rita ROMBOUTS, Gaston Stanislas Marcella DIELS, Michel SURKYN, Matthieu Dominique JOUFFROY
  • MACROCYCLIC INDOLE DERIVATIVES AS INHIBITORS OF MCL-1
    Publication number: 20230130109
    Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.
    Type: Application
    Filed: February 18, 2021
    Publication date: April 27, 2023
    Inventors: Frederik Jan Rita ROMBOUTS, Tristan REUILLON, Aldo PESCHIULLI, Adriana-Ingrid VELTER, Ann Marleen VOS
  • MACROCYLIC SULFONYL DERIVATIVES MCL-1 INHIBITORS
    Publication number: 20230029194
    Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.
    Type: Application
    Filed: November 20, 2020
    Publication date: January 26, 2023
    Inventors: Frederik Jan Rita ROMBOUTS, Benoit Christian Albert Ghislain De BOECK
  • MACROCYLIC INDOLE DERIVATIVES MCL-1 INHIBITORS
    Publication number: 20230021562
    Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.
    Type: Application
    Filed: November 20, 2020
    Publication date: January 26, 2023
    Inventors: Frederik Jan Rita ROMBOUTS, Benoit Christian Albert Ghi De BOECK
  • MACROCYCLIC INHIBITORS OF MCL-1
    Publication number: 20220306653
    Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.
    Type: Application
    Filed: June 18, 2020
    Publication date: September 29, 2022
    Inventors: Frederik Jan Rita ROMBOUTS, Aldo PESCHIULLI
  • TAU PET IMAGING LIGANDS
    Publication number: 20220024896
    Abstract: The present invention relates to novel, selective radiolabelled tau ligands which are useful for imaging and quantifying tau aggregates, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, to the use of such compounds and compositions for imaging a tissue or a subject, in vitro or in vivo, and to precursors of said compounds.
    Type: Application
    Filed: October 7, 2021
    Publication date: January 27, 2022
    Inventors: José Ignacio Andrés-Gil, Guy Maurits R. Bormans, Lieven Denis Herwig Declercq, Katleen Fierens, Joseph Elisabeth Leenaerts, Diederik Willem Elisabeth Moechars, Frederik Jan Rita Rombouts, Hartmuth Kolb, Wei Zhang
  • Tau PET imaging ligands
    Patent number: 11168068
    Abstract: The present invention relates to novel, selective radiolabelled tau ligands which are useful for imaging and quantifying tau aggregates, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, to the use of such compounds and compositions for imaging a tissue or a subject, in vitro or in vivo, and to precursors of said compounds.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: November 9, 2021
    Assignee: Janssen Pharmaceutica NV
    Inventors: José Ignacio Andrés-Gil, Guy Maurits R. Bormans, Lieven Denis Herwig Declercq, Katleen Fierens, Joseph Elisabeth Leenaerts, Diederik Willem Elisabeth Moechars, Frederik Jan Rita Rombouts, Hartmuth Kolb, Wei Zhang
  • TAU PET IMAGING LIGANDS
    Publication number: 20210283277
    Abstract: The present invention relates to novel, selective radiolabelled tau ligands which are useful for imaging and quantifying tau aggregates, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, to the use of such compounds and compositions for imaging a tissue or a subject, in vitro or in vivo, and to precursors of said compounds.
    Type: Application
    Filed: April 30, 2021
    Publication date: September 16, 2021
    Inventors: Diederik Willem Elisabeth MOECHARS, Frederik Jan Rita ROMBOUTS, Joseph Elisabeth LEENAERTS, José Ignacio ANDRéS-GIL, Katleen FIERENS, Vladimir CHUPAKHIN, Guy Mauritis R. BORMANS, Lieven Denis Herwig DECLERCQ, Hartmuth KOLB, Wei ZHANG
  • 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivatives
    Patent number: 10604523
    Abstract: The present invention relates to novel 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]-quinoxaline derivatives as inhibitors of phosphodiesterase 2 (PDE2) and to a lesser extent of phosphodiesterase 10 (PDE10) or as inhibitors of both, phosphodiesterases 2 and 10. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which PDE2 is involved, or disorders in which both PDE2 and PDE10 are involved, such as neurological and psychiatric disorders, and endocrinological or metabolic diseases. The present invention also relates to radiolabelled compounds which may be useful for imaging and quantifying the PDE2 enzyme in tissues, using positron-emission tomography (PET).
    Type: Grant
    Filed: June 26, 2012
    Date of Patent: March 31, 2020
    Assignee: Janssen Pharmaceutica NV
    Inventors: José Ignacio Andrés-Gil, Peter Jacobus Johannes Antonius Buijnsters, Andrés Avelino Trabanco-Suárez, Meri De Angelis, Greta Constantia Peter Vanhoof, Jérôme Emile Georges Guillemont, Frederik Jan Rita Rombouts, Maarten Vliegen, Guy Maurits R. Bormans, Sofie Jeanne Leopoldine Celen
  • Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
    Patent number: 10562897
    Abstract: The present invention is concerned with novel substituted pyrido-piperazinone derivatives of Formula (I) wherein R1, R2, R3, R4, R5, L, Z and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: February 18, 2020
    Assignee: JANSSEN PHARMACEUTICA NV
    Inventors: François Paul Bischoff, Adriana Ingrid Velter, Frederik Jan Rita Rombouts, Michel Anna Jozef De Cleyn, Sven Franciscus Anna Van Brandt, Henricus Jacobus Maria Gijsen, Chiara Zavattaro, Frans Alfons Maria Van den Keybus
  • TAU PET IMAGING LIGANDS
    Publication number: 20190284165
    Abstract: The present invention relates to novel, selective radiolabelled tau ligands which are useful for imaging and quantifying tau aggregates, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, to the use of such compounds and compositions for imaging a tissue or a subject, in vitro or in vivo, and to precursors of said compounds.
    Type: Application
    Filed: July 14, 2017
    Publication date: September 19, 2019
    Inventors: Jos ANDRéS-GIL Andres-Gil, Guy Maurits R. BORMANS, Lieven Denis Herwig DECLERCQ, Katleen FIERENS, Joseph Elisabeth LEENAERTS, Diederik Willem Elisabeth MOECHARS, Frederik Jan Rita ROMBOUTS, Hartmuth KOLB, Wei ZHANG
  • Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
    Patent number: 10246454
    Abstract: The present invention is concerned with novel substituted pyrido-piperazinone derivatives of Formula (I) wherein R1, R2, R3, R4, R5, L, Z and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: April 2, 2019
    Assignee: JANSSEN PHARMACEUTICA NV
    Inventors: François Paul Bischoff, Adriana Ingrid Velter, Frederik Jan Rita Rombouts, Michel Anna Jozef De Cleyn, Sven Franciscus Anna Van Brandt, Henricus Jacobus Maria Gijsen, Chiara Zavattaro, Frans Alfons Maria Van den Keybus
  • TAU PET IMAGING LIGANDS
    Publication number: 20190038784
    Abstract: The present invention relates to novel, selective radiolabelled tau ligands which are useful for imaging and quantifying tau aggregates, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, to the use of such compounds and compositions for imaging a tissue or a subject, in vitro or in vivo, and to precursors of said compounds.
    Type: Application
    Filed: February 1, 2017
    Publication date: February 7, 2019
    Inventors: Diederik Willem Elisabeth MOECHARS, Frederik Jan Rita ROMBOUTS, Joseph Elisabeth LEENAERTS, José Ignacio ANDRéS-GIL, Katleen FIERENS, Vladimir CHUPAKHIN, Guy Maurits R. BORMANS, Lieven Denis Herwig DECLERCQ, Hartmuth KOLB, Wei ZHANG