Abstract: The present invention relates to process for preparing a drug delivery composition comprising the steps of a) preparing a masterbatch comprising a drug and a first polymer by (i) extruding the first polymer, wherein said first polymer has a melting temperature below 140° C.; and (ii) introducing the drug during extrusion of the first polymer, with a drug content between 0.1% and 90%, based on the total weight of the masterbatch; and b) introducing the masterbatch in a polymer-based matrix during production of the drug delivery composition, wherein step a) is performed at a temperature at which the first polymer is in a partially or totally molten state, and step b) is performed at a temperature at which both the first polymer and at least a polymer of the polymer-based matrix are in a partially or totally molten state.

Abstract: The present invention relates to a new multicomponent plastic product comprising at least two different thermoplastic materials, wherein a first thermoplastic material comprises a first thermoplastic polymer, and a second thermoplastic material comprises a second thermoplastic polymer and a drug. According to the invention, the second thermoplastic material has a transformation temperature strictly lower than the transformation temperature of the first thermoplastic material and wherein the first and second plastic materials are at least partially adjacent in the multicomponent product.

Abstract: The present invention relates to a multicomponent plastic product comprising at least two different thermoplastic materials, wherein a first thermoplastic material comprises a first thermoplastic polymer, and a second thermoplastic material comprises at least a second thermoplastic polymer and at least one degrading enzyme able to degrade the first thermoplastic polymer. The second thermoplastic material has a transformation temperature lower than the transformation temperature of the first thermoplastic material, and the first and second plastic materials are at least partially adjacent in the multicomponent product.

Abstract: The present invention relates to process for preparing a drug delivery composition comprising the steps of a) preparing a masterbatch comprising a drug and a first polymer by (i) extruding the first polymer, wherein said first polymer has a melting temperature below 140° C.; and (ii) introducing the drug during extrusion of the first polymer, with a drug content between 0.1% and 90%, based on the total weight of the masterbatch; and b) introducing the masterbatch in a polymer-based matrix during production of the drug delivery composition, wherein step a) is performed at a temperature at which the first polymer is in a partially or totally molten state, and step b) is performed at a temperature at which both the first polymer and at least a polymer of the polymer-based matrix are in a partially or totally molten state.

Abstract: The present invention relates to a new drug delivery composition comprising a polymer-drug matrix wherein both a drug and a polymer-degrading enzyme are included. The invention further relates to a process for preparing such a drug delivery composition.

Abstract: The invention relates to a plastic compound comprising at least one polyolefin and a biological entity that degrades said polyolefin. The invention further relates to a process for preparing a plastic article wherein at least one polyolefin and one biological entity that degrades said polyolefin are mixed at a temperature at which the polyolefin is in a partially or totally molten state.

Abstract: The invention relates to a plastic compound comprising at least one polyolefin and a biological entity that degrades said polyolefin. The invention further relates to a process for preparing a plastic article wherein at least one polyolefin and one biological entity that degrades said polyolefin are mixed at a temperature at which the polyolefin is in a partially or totally molten state.

Abstract: The present invention relates to a method for degrading a plastic containing non-biodegradable polymers comprising submitting said plastic to at least one enzyme for modifying a polymer of said plastic which has a methane potential less than 5 Nm3/t+/?20%, wherein at least one product resulting from the modification exhibits a methane potential greater than 10 Nm3/t+/?20%.