Patents by Inventor Fredika Robertson

Fredika Robertson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of STAT3 and uses thereof
    Patent number: 8841257
    Abstract: Compounds which inhibit the activity of signal transducer and activator of transcription 3 (STAT3) are provided together with methods of making and using the same. The compounds are designed to bind to the SH2 domain of STAT3, preventing STAT3 from binding to receptors for interleukin-6 family cytokines, growth factors such as the platelet-derived growth factor, the epidermal growth factor, vascular endothelial growth factor, and other signaling molecules such as leptin. Blocking these interactions prevents STAT3 from being phosphorylated on Tyr705, which is required for the dimerization of STAT3, translocation to the nucleus, binding to STAT3 response elements on promotors, and transcription of genes. In addition to these activities, binding to the SH2 domain of STAT3 breaks up pre-formed dimmers, thereby preventing the transcriptional activity of the inhibitor.
    Type: Grant
    Filed: April 9, 2010
    Date of Patent: September 23, 2014
    Assignee: Board of Regents, The University of Texas System
    Inventors: John S. McMurray, Pijus K. Mandal, Warren S. Liao, Fredika Robertson, Xiaomin Chen, Ramesh Rajaopal, Zhiyong Ren
  • Nanoporous substrates for the analytical methods
    Patent number: 8753897
    Abstract: Nanoporous materials can be used to enrich samples for subsequent analysis of substances contained in the sample. The method is shown to enrich the yield of species in the low molecular weight proteome, allowing detection of small peptides in the low nanomolar range.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: June 17, 2014
    Assignees: The Board of Regents of The University of Texas System, The Ohio State Research Foundation
    Inventors: Mauro Ferrari, Mark Ming-Cheng Cheng, Giovanni Cuda, Marco Gaspari, David Geho, Lance Liotta, Emmanuel Petricoin, Fredika Robertson, Rosa Terracciano
  • INHIBITORS OF STAT3 AND USES THEREOF
    Publication number: 20120035114
    Abstract: Compounds which inhibit the activity of signal transducer and activator of transcription 3 (STAT3) are provided together with methods of making and using the same. The compounds are designed to bind to the SH2 domain of STAT3, preventing STAT3 from binding to receptors for interleukin-6 family cytokines, growth factors such as the platelet-derived growth factor, the epidermal growth factor, vascular endothelial growth factor, and other signaling molecules such as leptin. Blocking these interactions prevents STAT3 from being phosphorylated on Tyr705, which is required for the dimerization of STAT3, translocation to the nucleus, binding to STAT3 response elements on promotors, and transcription of genes. In addition to these activities, binding to the SH2 domain of STAT3 breaks up pre-formed dimmers, thereby preventing the transcriptional activity of the inhibitor.
    Type: Application
    Filed: April 9, 2010
    Publication date: February 9, 2012
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: John S. McMurray, Pijus K. Mandal, Warren S. Liao, Fredika Robertson, Xiaomin Chen, Ramesh Rajaopal, Zhiyong Ren
  • Vascular endothelial growth factors and methods of their use
    Patent number: 8067368
    Abstract: Vascular endothelial growth factor alternative splice variants and methods of their use are provided.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: November 29, 2011
    Assignees: The Ohio State University Research Foundation, Nationwide Children's Hospital, Inc.
    Inventors: Fredika Robertson, John Bauer
  • Vascular Endothelial Growth Factors And Methods Of Their Use
    Publication number: 20080299167
    Abstract: Vascular endothelial growth factor alternative splice variants and methods of their use are provided.
    Type: Application
    Filed: January 27, 2005
    Publication date: December 4, 2008
    Applicant: The Ohio State University Research Foundation Office of Technology Licensing
    Inventors: Fredika Robertson, John Bauer
  • Nanoporous substrates for the analytical methods
    Publication number: 20080277578
    Abstract: Nanoporous materials can be used to enrich samples for subsequent analysis of substances contained in the sample. The method is shown to enrich the yield of species in the low molecular weight proteome, allowing detection of small peptides in the low nanomolar range.
    Type: Application
    Filed: December 20, 2006
    Publication date: November 13, 2008
    Inventors: Mauro Ferrari, Mark Ming-Cheng Cheng, Giovanni Cuda, Marco Gaspari, David Geho, Lance Liotta, Emmanuel Petricoin, Fredika Robertson, Rosa Terracciano