Patents by Inventor Fredrik Ek
Fredrik Ek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210296012Abstract: A method and apparatus for energy production comprising providing reactive material containing, at least, an exothermic double electron capture capable isotope and supplying pair-formation energy to at least part of the reactive material to form at least one irreversible double electron capture capable nuclei-pair to produce a net exothermic reaction is disclosed. The reactive material may comprise a metallic alloy. A method and apparatus for energy production comprising heating a three or more element metallic alloy in a chemically inert atmosphere to initiate and/or sustain an exothermic reaction between at least two of the metallic elements of the alloy is herein disclosed. The pressure at the surface of the metallic alloy may be maintained below 1000 atm. The reaction may be initiated, maintained or re-initiated by temperature cycling within a target temperature range.Type: ApplicationFiled: August 29, 2017Publication date: September 23, 2021Inventors: Andras KOVACS, David Brown, Fredrik EK
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Publication number: 20210225531Abstract: This disclosure relates to a method and apparatus for energy production from at least one of electron-mediated nuclear reaction and single-element nuclear reaction, wherein a reactive nuclei fuel is loaded into a reactor. The fuel includes one or more reactive nuclei. To maintain a chain reaction, the fuel structure has a multiplication factor of energetic electrons larger than one. A chain reaction is initiated and/or periodically re-initiated in the fuel.Type: ApplicationFiled: March 8, 2019Publication date: July 22, 2021Inventors: David BROWN, Andras KOVACS, Fredrik EK
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Patent number: 10363411Abstract: A medical microelectrode includes an elongate electrode body including a tip section, a main body section and, optionally, a coupling section. The tip section, the main body section and, optionally, the coupling section are embedded in a first electrode matrix element, which is substantially rigid, biocompatible and soluble or biodegradable in a body fluid. Additionally the microelectrode includes a dissolution retarding layer on the first electrode matrix element and/or a second electrode matrix element disposed between the first electrode matrix element and the electrode. Upon dissolution or biodegradation of the first electrode matrix element a drug comprised by the first electrode matrix element or the second electrode matrix element is released into the tissue. Also disclosed are bundles and arrays of the electrodes and their use.Type: GrantFiled: June 13, 2017Date of Patent: July 30, 2019Assignee: NEURONANO ABInventors: Fredrik Ek, Nils Danielsen, Jenny Eriksson Linsmeier, Per Petersson, Jens Schouenborg
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Patent number: 10188854Abstract: A medical microelectrode includes an elongate electrode body including a tip section, a main body section and, optionally, a coupling section. The tip section, the main body section and, optionally, the coupling section are embedded in a first electrode matrix element, which is substantially rigid, biocompatible and soluble or biodegradable in a body fluid. Additionally the microelectrode includes a dissolution retarding layer on the first electrode matrix element and/or a second electrode matrix element disposed between the first electrode matrix element and the electrode. Upon dissolution or biodegradation of the first electrode matrix element a drug comprised by the first electrode matrix element or the second electrode matrix element is released into the tissue. Also disclosed are bundles and arrays of the electrodes and their use, which may be positioned on a face of a solid support.Type: GrantFiled: December 8, 2016Date of Patent: January 29, 2019Assignee: NEURONANO ABInventors: Fredrik Ek, Nils Danielsen, Jenny Eriksson Linsmeier, Per Petersson, Jens Schouenborg
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Patent number: 9878147Abstract: A medical microelectrode includes an elongate electrode body including a tip section, a main body section and, optionally, a coupling section. The tip section, the main body section and, optionally, the coupling section are embedded in a first electrode matrix element, which is substantially rigid, biocompatible and soluble or biodegradable in a body fluid. Additionally the microelectrode includes a dissolution retarding layer on the first electrode matrix element and/or a second electrode matrix element disposed between the first electrode matrix element and the electrode. Upon dissolution or biodegradation of the first electrode matrix element a drug comprised by the first electrode matrix element or the second electrode matrix element is released into the tissue. Also disclosed are bundles and arrays of the electrodes and their use.Type: GrantFiled: February 6, 2015Date of Patent: January 30, 2018Assignee: NEURONANO ABInventors: Fredrik Ek, Nils Danielsen, Jenny Eriksson Linsmeier, Per Petersson, Jens Schouenborg
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Publication number: 20170274201Abstract: A medical microelectrode includes an elongate electrode body including a tip section, a main body section and, optionally, a coupling section. The tip section, the main body section and, optionally, the coupling section are embedded in a first electrode matrix element, which is substantially rigid, biocompatible and soluble or biodegradable in a body fluid. Additionally the microelectrode includes a dissolution retarding layer on the first electrode matrix element and/or a second electrode matrix element disposed between the first electrode matrix element and the electrode. Upon dissolution or biodegradation of the first electrode matrix element a drug comprised by the first electrode matrix element or the second electrode matrix element is released into the tissue. Also disclosed are bundles and arrays of the electrodes and their use.Type: ApplicationFiled: June 13, 2017Publication date: September 28, 2017Inventors: Fredrik EK, Nils DANIELSEN, Jenny ERIKSSON LINSMEIER, Per PETERSSON, Jens SCHOUENBORG
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Publication number: 20170087352Abstract: A medical microelectrode includes an elongate electrode body including a tip section, a main body section and, optionally, a coupling section. The tip section, the main body section and, optionally, the coupling section are embedded in a first electrode matrix element, which is substantially rigid, biocompatible and soluble or biodegradable in a body fluid. Additionally the microelectrode includes a dissolution retarding layer on the first electrode matrix element and/or a second electrode matrix element disposed between the first electrode matrix element and the electrode. Upon dissolution or biodegradation of the first electrode matrix element a drug comprised by the first electrode matrix element or the second electrode matrix element is released into the tissue. Also disclosed are bundles and arrays of the electrodes and their use, which may be positioned on a face of a solid support.Type: ApplicationFiled: December 8, 2016Publication date: March 30, 2017Applicant: NEURONANO ABInventors: Fredrik EK, Nils DANIELSEN, Jenny ERIKSSON LINSMEIER, Per PETERSSON, Jens SCHOUENBORG
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Patent number: 9533140Abstract: A medical microelectrode includes an elongate electrode body including a tip section, a main body section and, optionally, a coupling section. The tip section, the main body section and, optionally, the coupling section are embedded in a first electrode matrix element, which is substantially rigid, biocompatible and soluble or biodegradable in a body fluid. Additionally the microelectrode includes a dissolution retarding layer on the first electrode matrix element and/or a second electrode matrix element disposed between the first electrode matrix element and the electrode. Upon dissolution or biodegradation of the first electrode matrix element a drug comprised by the first electrode matrix element or the second electrode matrix element is released into the tissue. Also disclosed are bundles and arrays of the electrodes and their use.Type: GrantFiled: July 11, 2014Date of Patent: January 3, 2017Assignee: NEURONANO ABInventors: Fredrik Ek, Nils Danielsen, Jenny Eriksson Linsmeier, Per Petersson, Jens Schouenborg
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Publication number: 20150151109Abstract: A medical microelectrode includes an elongate electrode body including a tip section, a main body section and, optionally, a coupling section. The tip section, the main body section and, optionally, the coupling section are embedded in a first electrode matrix element, which is substantially rigid, biocompatible and soluble or biodegradable in a body fluid. Additionally the microelectrode includes a dissolution retarding layer on the first electrode matrix element and/or a second electrode matrix element disposed between the first electrode matrix element and the electrode. Upon dissolution or biodegradation of the first electrode matrix element a drug comprised by the first electrode matrix element or the second electrode matrix element is released into the tissue. Also disclosed are bundles and arrays of the electrodes and their use.Type: ApplicationFiled: February 6, 2015Publication date: June 4, 2015Inventors: Fredrik Ek, Nils Danielsen, Jenny Eriksson Linsmeier, Per Petersson, Jens Schouenborg
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Patent number: 9040637Abstract: Disclosed herein are nanostructures comprising a polymeric framework comprising at least five geminal bisphosphonate groups, wherein the geminal bisphosphonate groups independently of each other are incorporated as —R3R4C(P?O(OR1)(OR2))2, wherein R1 and R2 are independently selected from the group consisting of a negative charge, H, alkyl and aryl, and wherein at least one of R3 and R4 is a group connected to the polymeric framework with the proviso that when only one of R3 and R4 is such a connected group, the other of R3 and R4 is either a group being able to connect to the polymeric framework, or the residue of such a group, or selected from the group consisting of H, OH, OR5 and R5, wherein R5 is a lower alkyl. The polymeric framework may comprise manganese ions. Disclosed are also methods for producing such manganese containing nanostructures, compositions comprising such manganese containing nanostructures and use of such manganese containing nanostructures, i.a. as MRI contrasting agents.Type: GrantFiled: September 20, 2012Date of Patent: May 26, 2015Assignee: SPAGO IMAGING ABInventors: Oskar Axelsson, Rodrigo M. Petoral, Jr., Fredrik Ek, Petter Lauritzson
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Patent number: 8954142Abstract: A medical microelectrode includes an elongate electrode body including a tip section, a main body section and, optionally, a coupling section. The tip section, the main body section and, optionally, the coupling section are embedded in a first electrode matrix element, which is substantially rigid, biocompatible and soluble or biodegradable in a body fluid. Additionally the microelectrode includes a dissolution retarding layer on the first electrode matrix element and/or a second electrode matrix element disposed between the first electrode matrix element and the electrode. Upon dissolution or biodegradation of the first electrode matrix element a drug comprised by the first electrode matrix element or the second electrode matrix element is released into the tissue. Also disclosed are bundles and arrays of the electrodes and their use.Type: GrantFiled: June 3, 2010Date of Patent: February 10, 2015Assignee: Nauronano ABInventors: Fredrik Ek, Nils Danielsen, Jenny Eriksson Linsmeier, Per Petersson, Jens Schouenborg
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Publication number: 20140350193Abstract: Disclosed herein are nanostructures comprising a polymeric framework comprising at least five geminal bisphosphonate groups, wherein the geminal bisphosphonate groups independently of each other are incorporated as —R3R4C(P?O(OR1)(OR2))2, wherein R1 and R2 are independently selected from the group consisting of a negative charge, H, alkyl and aryl, and wherein at least one of R3 and R4 is a group connected to the polymeric framework with the proviso that when only one of R3 and R4 is such a connected group, the other of R3 and R4 is either a group being able to connect to the polymeric framework, or the residue of such a group, or selected from the group consisting of H, OH, OR5 and R5, wherein R5 is a lower alkyl. The polymeric framework may comprise manganese ions. Disclosed are also methods for producing such manganese containing nanostructures, compositions comprising such manganese containing nanostructures and use of such manganese containing nanostructures, i.a. as MRI contrasting agents.Type: ApplicationFiled: September 20, 2012Publication date: November 27, 2014Inventors: Oskar Axelsson, Rodrigo M. Petoral, JR., Fredrik Ek, Petter Lauritzson
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Publication number: 20140323948Abstract: A medical microelectrode includes an elongate electrode body including a tip section, a main body section and, optionally, a coupling section. The tip section, the main body section and, optionally, the coupling section are embedded in a first electrode matrix element, which is substantially rigid, biocompatible and soluble or biodegradable in a body fluid. Additionally the microelectrode includes a dissolution retarding layer on the first electrode matrix element and/or a second electrode matrix element disposed between the first electrode matrix element and the electrode. Upon dissolution or biodegradation of the first electrode matrix element a drug comprised by the first electrode matrix element or the second electrode matrix element is released into the tissue. Also disclosed are bundles and arrays of the electrodes and their use.Type: ApplicationFiled: July 11, 2014Publication date: October 30, 2014Inventors: Fredrik Ek, Nils Danielsen, Jenny Eriksson Linsmeier, Per Petersson, Jens Schouenborg
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Publication number: 20130022669Abstract: The present invention relates to branched polyethyleneglycol (PEG) derivatives consisting of a molecule with a quaternary carbon connected to three PEG chains, wherein all three PEG chains are of equal length and each comprises 1-30 —OCH2CH2— units, and one group with at least one carbon atom, wherein said at least one carbon atom is attached to the quaternary carbon. Also compositions containing such derivatives and use of such derivatives are disclosed.Type: ApplicationFiled: March 29, 2011Publication date: January 24, 2013Applicant: SPAGO IMAGING ABInventors: Oskar Axelsson, Fredrik Ek
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Publication number: 20120123318Abstract: A medical microelectrode includes an elongate electrode body including a tip section, a main body section and, optionally, a coupling section. The tip section, the main body section and, optionally, the coupling section are embedded in a first electrode matrix element, which is substantially rigid, biocompatible and soluble or biodegradable in a body fluid. Additionally the microelectrode includes a dissolution retarding layer on the first electrode matrix element and/or a second electrode matrix element disposed between the first electrode matrix element and the electrode. Upon dissolution or biodegradation of the first electrode matrix element a drug comprised by the first electrode matrix element or the second electrode matrix element is released into the tissue. Also disclosed are bundles and arrays of the electrodes and their use.Type: ApplicationFiled: June 3, 2010Publication date: May 17, 2012Inventors: Fredrik Ek, Nils Danielsen, Jenny Eriksson Linsmeier, Per Petersson, Jens Schouenborg
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Publication number: 20100129473Abstract: Disclosed herein are analogs of clozapine and pharmaceutically acceptable salts, esters, amides, or prodrugs thereof; methods of synthesizing the analogs; and methods of using the analogs for treating neuropsychiatric disorders. In some embodiments, the analogs are amino substituted diaryl[a,d]cycloheptenes.Type: ApplicationFiled: November 18, 2009Publication date: May 27, 2010Applicant: ACADIA Pharmaceuticals, Inc.Inventors: Fredrik Ek, Roger Olsson, Jörgen Ohlsson
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Patent number: 7622461Abstract: Disclosed herein are analogs of clozapine and pharmaceutically acceptable salts, esters, amides, or prodrugs thereof, methods of synthesizing the analogs; and methods of using the analogs for treating neuropsychiatric disorders. In some embodiments, the analogs are amino substituted diaryl[a,d]cycloheptenes.Type: GrantFiled: April 10, 2007Date of Patent: November 24, 2009Assignee: ACADIA Pharmaceuticals Inc.Inventors: Fredrik Ek, Roger Olsson, Jörgen Ohlsson
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Publication number: 20090239840Abstract: Disclosed herein are analogs of clozapine and pharmaceutically acceptable salts, esters, amides, or prodrugs thereof; methods of synthesizing the analogs; and methods of using the analogs for treating neuorpsychiatric disorders. In some embodiments, the analogs are amino substituted diaryl[a,d]cycloheptenes.Type: ApplicationFiled: February 12, 2009Publication date: September 24, 2009Applicant: ACADIA PHARMACEUTICALS, INC.Inventors: Fredrik Ek, Roger Olsson, Jorgen Ohlsson
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Patent number: 7550454Abstract: Disclosed herein are analogs of clozapine and pharmaceutically acceptable salts, esters, amides, or prodrugs thereof; methods of synthesizing the analogs; and methods of using the analogs for treating neuropsychiatric disorders. In some embodiments, the analogs are amino substituted diaryl[a,d]cycloheptenes.Type: GrantFiled: December 21, 2004Date of Patent: June 23, 2009Assignee: ACADIA Pharmaceuticals, Inc.Inventors: Fredrik Ek, Roger Olsson, Jörgen Ohlsson
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Patent number: 7517871Abstract: Disclosed herein are analogs of clozapine and pharmaceutically acceptable salts, esters, amides, or prodrugs thereof; methods of synthesizing the analogs; and methods of using the analogs for treating neuorpsychiatric disorders. In some embodiments, the analogs are amino substituted diaryl[a,d]cycloheptenes.Type: GrantFiled: May 3, 2006Date of Patent: April 14, 2009Assignee: Acadia Pharmaceuticals, Inc.Inventors: Fredrik Ek, Roger Olsson, Jörgen Ohlsson