Patents by Inventor Fredrik Hook
Fredrik Hook has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230338519Abstract: The present invention relates to a fusion protein, a nucleotide sequence encoding such a fusion protein, the use thereof as an adjuvant or vaccine. The fustin protein comprises a bacterial exotoxin and a single chain antibody fragment (scFv) that specifically binds to a surface marker on dendritic cells. The fusion protein is advantageously administered intranasally, orally or intrapulmonarily.Type: ApplicationFiled: May 14, 2021Publication date: October 26, 2023Inventors: Nils Lycke, Mohammad Arabpour, Fredrik Höök
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Publication number: 20220252589Abstract: Described is a sample holder assembly including a functionalized test well wall, which may be used in combination with a light source.Type: ApplicationFiled: April 27, 2022Publication date: August 11, 2022Inventors: Tim Kaminski, Fredrik Höök
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Patent number: 11346839Abstract: The disclosure concerns a method for determining the interaction between a test compound and a receptor. The receptor may be immobilized. The disclosure also concerns a sample holder assembly including a functionalized test well wall, which may be used in combination with a Total Internal Reflection Fluorescence source.Type: GrantFiled: August 2, 2019Date of Patent: May 31, 2022Assignee: INSINGULO ABInventors: Tim Kaminski, Fredrik Höök
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Publication number: 20210181193Abstract: The disclosure concerns a method for determining the interaction between a test compound and a receptor. The receptor may be immobilized. The disclosure also concerns a sample holder assembly including a functionalized test well wall, which may be used in combination with a Total Internal Reflection Fluorescence source.Type: ApplicationFiled: August 2, 2019Publication date: June 17, 2021Inventors: Tim Kaminski, Fredrik Höök
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Patent number: 10794816Abstract: The disclosure relates to a method for determining a hydrodynamic size of an object, such as a nano-sized object, said method comprising the steps of: —providing a fluid interface, —linking said object to said fluid interface thereby providing a linked object, whereby the movement of said linked object is restricted by virtue of being linked to said fluid interface, —providing and determining a hydrodynamic shear force that acts on said linked object, —tracking the movement of said linked object, and —calculating the hydrodynamic size of the object using the Einstein-Smoluchowski relation.Type: GrantFiled: December 2, 2016Date of Patent: October 6, 2020Assignee: GOTHENBURG SENSOR DEVICES ABInventors: Fredrik Höök, Stephan Block, Björn Johansson Fast, Anders Lundgren
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Publication number: 20180356332Abstract: The disclosure relates to a method for determining a hydrodynamic size of an object, such as a nano-sized object, said method comprising the steps of: —providing a fluid interface, —linking said object to said fluid interface thereby providing a linked object, whereby the movement of said linked object is restricted by virtue of being linked to said fluid interface, —providing and determining a hydrodynamic shear force that acts on said linked object, —tracking the movement of said linked object, and —calculating the hydrodynamic size of the object using the Einstein-Smoluchowski relation.Type: ApplicationFiled: December 2, 2016Publication date: December 13, 2018Inventors: Fredrik Höök, Stephan Block, Björn Johansson Fast, Anders Lundgren
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Patent number: 9784746Abstract: The present invention provides a method for studying transport of an agent across a membrane comprising the steps a) providing at least one surface with a bilayer structure tethered to the surface, said bilayer structure comprising a detection volume, b) contacting the bilayer with at least one agent to be analyzed, and c) detecting a change in refractive index in the detection volume resulting from transportation of the agent across the membrane. Further there is provided a device comprising a) at least one surface, b) at least one bilayer structure tethered to the surface, and c) at least one sensor capable of detecting a change in refractive index in a detection volume, wherein the bilayer structure encloses a first volume of the detection volume and wherein the volume not enclosed by the bilayer structure but within the detection volume is a second volume and wherein the ratio between the first volume and second volume is above about 0.001.Type: GrantFiled: April 18, 2016Date of Patent: October 10, 2017Assignee: Bio-Rad Laboratories, Inc.Inventors: Fredrik Höök, Magnus Brändén, Seyed Tabaei
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Patent number: 9606047Abstract: A waveguide structure for evanescent wave microscopy and/or spectroscopy, comprising an optically transparent core layer, a lower dielectric cladding layer and an upper dielectric cladding layer arranged on opposite sides of the core layer. The core layer has a refractive index higher than the refractive indices of the cladding layers. The upper cladding layer is made of an organic material. A sample well is arranged on an upper surface of the core layer formed by a cavity in the upper cladding layer, the sample well being adapted to contain a sample medium with one or more sample objects. The core layer is made of a first dielectric inorganic material, and the upper cladding layer has a refractive index which closely matches the refractive index of the sample medium. A method for manufacturing such waveguide structure, and a measurement system comprising the waveguide structure are also disclosed.Type: GrantFiled: June 26, 2014Date of Patent: March 28, 2017Assignee: GOTHENBURG SENSOR DEVICES ABInventors: Fredrik Höök, Björn Agnarsson, Anders Lundgren, Anders Gunnarsson, Marta Bally, Lisa Simonsson Nyström
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Publication number: 20160231326Abstract: The present invention provides a method for studying transport of an agent across a membrane comprising the steps a) providing at least one surface with a bilayer structure tethered to the surface, said bilayer structure comprising a detection volume, b) contacting the bilayer with at least one agent to be analyzed, and c) detecting a change in refractive index in the detection volume resulting from transportation of the agent across the membrane. Further there is provided a device comprising a) at least one surface, b) at least one bilayer structure tethered to the surface, and c) at least one sensor capable of detecting a change in refractive index in a detection volume, wherein the bilayer structure encloses a first volume of the detection volume and wherein the volume not enclosed by the bilayer structure but within the detection volume is a second volume and wherein the ratio between the first volume and second volume is above about 0.001.Type: ApplicationFiled: April 18, 2016Publication date: August 11, 2016Applicant: Bio-Rad Laboratories, Inc.Inventors: Fredrik Höök, Magnus Brändén, Seyed Tabaei
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Publication number: 20160153888Abstract: A waveguide structure for evanescent wave microscopy and/or spectroscopy, comprising an optically transparent core layer, a lower dielectric cladding layer and an upper dielectric cladding layer arranged on opposite sides of the core layer. The core layer has a refractive index higher than the refractive indices of the cladding layers. The upper cladding layer is made of an organic material. A sample well is arranged on an upper surface of the core layer formed by a cavity in the upper cladding layer, the sample well being adapted to contain a sample medium with one or more sample objects. The core layer is made of a first dielectric inorganic material, and the upper cladding layer has a refractive index which closely matches the refractive index of the sample medium. A method for manufacturing such waveguide structure, and a measurement system comprising the waveguide structure are also disclosed.Type: ApplicationFiled: June 26, 2014Publication date: June 2, 2016Applicant: GOTHENBURG SENSOR DEVICES ABInventors: Fredrik Höök, Björn Agnarsson, Anders Lundgren, Anders Gunnarsson, Marta Bally, Lisa Simonsson
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Patent number: 9322830Abstract: The present invention provides a method for studying transport of an agent across a membrane comprising the steps a) providing at least one surface with a bilayer structure tethered to the surface, said bilayer structure comprising a detection volume, b) contacting the bilayer with at least one agent to be analyzed, and c) detecting a change in refractive index in the detection volume resulting from transportation of the agent across the membrane. Further there is provided a device comprising a) at least one surface, b) at least one bilayer structure tethered to the surface, and c) at least one sensor capable of detecting a change in refractive index in a detection volume, wherein the bilayer structure encloses a first volume of the detection volume and wherein the volume not enclosed by the bilayer structure but within the detection volume is a second volume and wherein the ratio between the first volume and second volume is above about 0.001.Type: GrantFiled: April 22, 2014Date of Patent: April 26, 2016Assignee: Bio-Rad Laboratories, Inc.Inventors: Fredrik Hook, Magnus Branden, Seyed Tabaei
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Publication number: 20150031139Abstract: The present invention provides a method for studying transport of an agent across a membrane comprising the steps a) providing at least one surface with a bilayer structure tethered to the surface, said bilayer structure comprising a detection volume, b) contacting the bilayer with at least one agent to be analyzed, and c) detecting a change in refractive index in the detection volume resulting from transportation of the agent across the membrane. Further there is provided a device comprising a) at least one surface, b) at least one bilayer structure tethered to the surface, and c) at least one sensor capable of detecting a change in refractive index in a detection volume, wherein the bilayer structure encloses a first volume of the detection volume and wherein the volume not enclosed by the bilayer structure but within the detection volume is a second volume and wherein the ratio between the first volume and second volume is above about 0.001.Type: ApplicationFiled: April 22, 2014Publication date: January 29, 2015Applicant: Bio-Rad Laboratories, Inc.Inventors: Fredrik Hook, Magnus Branden, Seyed Tabaei
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Publication number: 20120184047Abstract: The present invention relates to a solution for nanoplasmonic measurement using a nanoplasmonic device with a short range order structure of trough going channels in contact with a fluid flow cell. The device is manufactured in a micro machine process comprising steps of using combined colloidal lithography, thin film deposition and etching steps on the micro/nano scale, for chemical or bio analytical sensing, and other uses. The solution makes use of shifts in the nanoplasmonic resonance, an optical property of the device that is sensitive to changes in refractive index induced by molecular reactions or other processes.Type: ApplicationFiled: September 27, 2010Publication date: July 19, 2012Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: Magnus P. Jonsson, Fredrik Hook
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Publication number: 20110008902Abstract: The present invention provides a method for studying transport of an agent across a membrane comprising the steps a) providing at least one surface with a bilayer structure tethered to the surface, said bilayer structure comprising a detection volume, b) contacting the bilayer with at least one agent to be analysed, and c) detecting a change in refractive index in the detection volume resulting from transportation of the agent across the membrane. Further there is provided a device comprising a) at least one surface, b) at least one bilayer structure tethered to the surface, and c) at least one sensor capable of detecting a change in refractive index in a detection volume, wherein the bilayer structure encloses a first volume of the detection volume and wherein the volume not enclosed by the bilayer structure but within the detection volume is a second volume and wherein the ratio between the first volume and second volume is above about 0.001.Type: ApplicationFiled: February 6, 2009Publication date: January 13, 2011Applicant: Layeriab AktiebolagInventors: Fredrik Hook, Magnus Branden, Seyed Tabaei
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Patent number: 6006589Abstract: A device and a process for measuring resonant frequency and dissipation factor of a piezoelectric resonator are presented. After exciting the resonator to oscillation, the driving power to the oscillator is turned off after the decay of the oscillation of the resonator is recorded and used to give a measure of at least one of the resonators properties, such as dissipation factor, changes in the dissipation factor, resonant frequency and changes in the resonant frequency.Type: GrantFiled: September 25, 1997Date of Patent: December 28, 1999Assignee: O-Sense ABInventors: Michael Rodahl, Fredrik Hook, Anatol Krozer, Bengt Kasemo