Abstract: A method for determining whether a mammalian subject having a malignant melanoma belongs to a first or a second group, wherein the prognosis of subjects of the first group is better than the prognosis of subjects of the second group is provided. The method comprises the steps of: evaluating an amount of RBM3 protein in at least part of a sample earlier obtained from the subject and determining a sample value corresponding to the evaluated amount; comparing said sample value with a predetermined reference value; and if said sample value is higher than said reference value, concluding that the subject belongs to the first group; and if said sample value is lower than or equal to said reference value, concluding that the subject belongs to the second group.

Abstract: The invention provides new methods, means and uses in connection with detection, characterization and prognosis of colo-rectal cancer, via the identification of the SATB2 protein as a marker for this cancer type.

Abstract: The present disclosure provides a method for determining whether a mammalian subject having a colorectal cancer belongs to a first or a second group, wherein the prognosis of subjects of the first group is better than the prognosis of subjects of the second group, comprising the steps of: a) evaluating an amount of PODXL protein in at least part of a sample earlier obtained from the subject, and determining a sample value corresponding to the evaluated amount; b) comparing said sample value from step a) with a predetermined reference value; and if said sample value is higher than said reference value, c1) concluding that the subject belongs to said second group; and if said sample value is lower than or equal to said reference value, c2) concluding that the subject belongs to said first group. Related uses, means and a method of treatment are also provided.

Abstract: The invention provides new methods, means and uses in connection with detection, characterization and prognosis of colo-rectal cancer, via the identification of the SATB2 protein as a marker for this cancer type.

Abstract: Apparatus for washing and dewatering pulp including a pair of rotatable press rolls with a permeable outer surface in a casing including a vat in which the press rolls are installed is provided. A gap is provided between the vat and the press rolls as well as means for feeding the pulp into the gap between the rolls and the vat includes a first segment partially enclosing the first roll and a second segment partially enclosing the second roll, and casing members for each segment are pivotable about axes of rotation to open and close the casing, and the distance between the axes of rotation is less than the sum of the outer diameter of the two press rolls.

Abstract: There is provided a method for determining whether a mammalian subject having an ovarian cancer belongs to a first or a second group, wherein the prognosis of subjects of the first group is better than the prognosis of subjects of the second group, comprising the steps of: a) evaluating an amount of RBM3 protein in at least part of a sample earlier obtained from the subject and determining a sample value corresponding to the evaluated amount; b) comparing said sample value with a predetermined refer-ence value; and if said sample value is higher than said ref-erence value, c1) concluding that the subject belongs to the first group; and if said sample value is lower than or equal to said reference value, c2) concluding that the sub-ject belongs to the second group. Related peptides, affinity ligands, uses and further methods are also provided.

Abstract: The present invention provides means, such as a method, for determining whether a mammalian subject having a colorectal cancer belongs to a first or a second group, wherein the prognosis of subjects of the first group is better than the prognosis of subjects of the second group. The method comprises the steps of: evaluating an amount of RBM3 protein or RBM3 mRNA molecule in at least part of a sample earlier obtained from the subject and determining a sample value corresponding to the evaluated amount; comparing said sample value with a predetermined reference value; and if said sample value is higher than said reference value, concluding that the subject belongs to the first group; and if said sample value is lower than or equal to said reference value, concluding that the subject belongs to the second group.

Abstract: The invention provides new methods, means and uses in connection with detection, characterization and prognosis of colo-rectal cancer, via the identification of the SATB2 protein as a marker for this cancer type.

Abstract: The invention provides new methods, means and uses in connection with detection, characterization and prognosis of colo-rectal cancer, via the identification of the SATB2 protein as a marker for this cancer type.

Abstract: The present invention provides methods, uses and means for breast cancer prognostics and treatment prediction. Provided methods comprises the steps of: providing a sample earlier obtained from a breast cancer subject; evaluating the amount of ANLN protein present in at least part of said sample, and determining a sample value corresponding to said amount; comparing the sample value with a reference value; and, if said sample value is higher than said reference value, concluding that the subject is not likely to benefit from an endocrine treatment or that a prognosis for said subject is worse than a reference prognosis associated with the reference value.

Abstract: The present invention relates to an affinity ligand capable of selective interaction with an epitope sequence consisting of 47 amino acids or less and comprising the amino acid sequence of SEQ ID NO:1 and/or SEQ ID NO:2. Further, it relates to a polypeptide consisting of the epitope sequence and to uses of the affinity ligand and the polypeptide.

Abstract: The present invention provides new methods, uses and means for breast cancer prognostics. The provided method for establishing a prognosis for a mammalian subject having a breast cancer, comprises the steps of: obtaining a hormone receptor status of the subject; obtaining an HMGCR protein value of the subject; and correlating the hormone receptor status and the HMGCR protein of the subject to a prognosis for the subject.

Abstract: The present invention provides a method for determining whether a mammalian subject having a breast cancer is likely to benefit from an endocrine treatment, comprising the steps of: providing a sample earlier obtained from said subject; evaluating the amount of HMGCR protein or HMGCR mRNA present in at least part of said sample, and determining a sample value corresponding to said amount; comparing the sample value obtained in step b) with a reference value; and, if said sample value is higher than said reference value, concluding that the subject is likely to benefit from an endocrine treatment. Further, a corresponding method of treatment is provided as well as further methods uses and means which may be employed in connection with breast cancer treatment or treatment prediction.

Abstract: Apparatus for washing and dewatering pump comprising a pair of rotatable press rolls with permeable outer surfaces, a casing comprising a vat in which the rolls are installed, and a feed for feeding the pulp to the gap formed between the vat and the press roll is disclosed. The vat includes a first side vat segment partially enclosing the first press roll and a second side vat segment partially enclosing the second press roll and casing members for each of the vat segments, the first casing member being pivotable about an axis of rotation and between closed and open positions, pulp distribution devices for distributing pulp onto the press rolls, at least one of the pulp distribution devices being mounted on the casing member whereby it is moved away from the press roll together with the casing member when it is opened.

Abstract: The present invention provides means, such as a method, for determining whether a prognosis for a mammalian subject having a breast cancer is better than a reference prognosis. The method comprises the steps of: providing a sample earlier obtained from the subject; evaluating the amount of RBM3 protein present in at least part of said sample, and determining a sample value corresponding to said evaluated amount; comparing the sample value obtained with a reference value associated with said reference prognosis; and, if said sample value is higher than said reference value, concluding that the prognosis for said subject is better than said reference prognosis.

Abstract: The present invention provides a new method and means for determining whether a mammalian subject having a breast cancer is likely to benefit from an endocrine treatment. The method comprise the steps of: providing a sample earlier obtained from said subject; evaluating the amount of CRABP2 protein present in at least part of said sample, and determining a sample value corresponding to said amount; comparing the obtained sample value with a reference value; and, if said sample value is higher than said reference value, concluding that the subject is likely to benefit from an endocrine treatment.

Abstract: Apparatus for washing and dewatering pulp comprising rotatable press rolls including permeable outer surfaces and a casing comprising a vat in which the rolls are installed are disclosed. A feed for feeding the pulp through the gap between the vat and the outer surfaces of the press rolls is provided and the vat includes a vat segment providing at least one compartment between the vat segment and the casing, the at least one compartment extending along the longitudinal extension of one of the first and second rotatable press rolls and a pressure device to maintain the pressure in the at least one compartment corresponding to the pressure in the gap.

Abstract: Methods for processing pulp in an apparatus for washing and dewatering pulp and a system for controlling this apparatus are provided. The apparatus includes a pair of rotatable press rolls installed in vats and including a press nip therebetween, an inlet for feeding the pulp to the press nip, with one of the press rolls being movable in relation to the other and in which the processing of the pulp is determined by the number of variable operating parameters. The method includes utilizing the distance between the press rolls as a variable operating parameter, setting a desired value for a specific control parameter, measuring the specific control parameter, and adjusting at least two of the variable operating parameters during operation to maintain the difference between the desired value and the measured value of the specific control parameter below a predetermined difference. Systems for controlling this apparatus are also disclosed.

Abstract: Apparatus for washing and dewatering pulp including a pair of rotatable press rolls with a permeable outer surface in a casing including a vat in which the press rolls are installed is provided. A gap is provided between the vat and the press rolls as well as means for feeding the pulp into the gap between the rolls and the vat includes a first segment partially enclosing the first roll and a second segment partially enclosing the second roll, and casing members for each segment are pivotable about axes of rotation to open and close the casing, and the distance between the axes of rotation is less than the sum of the outer diameter of the two press rolls.

Abstract: Apparatus for creating a seal between an axle journal and a bearing housing is disclosed, particularly for use in apparatus for dewatering or washing material suspensions. The apparatus includes a stator ring, a pair of diagonally disposed guide pins supporting the stator ring with respect to the bearing housing so that the stator ring can be angled in a plane with respect to the pair of guide pins, a sealing ring for creating a seal between the stator ring and the axle journal, a bellows for creating a seal between the bearing housing and the stator ring, and at least one resilient member for urging the stator ring in abutment against the sealing ring.